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1. WO2022043400 - NUCLEIC ACIDS ENCODING A POLYPEPTIDE COMPRISING A MODIFIED FC REGION OF A HUMAN IGG1 AND AT LEAST ONE HETEROLOGOUS ANTIGEN

Publication Number WO/2022/043400
Publication Date 03.03.2022
International Application No. PCT/EP2021/073542
International Filing Date 25.08.2021
IPC
A61K 39/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
C12N 15/62 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
CPC
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/55516
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55516Proteins; Peptides
A61K 2039/572
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
572cytotoxic response
A61K 2039/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
575humoral response
A61K 39/001156
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001154Enzymes
001156Tyrosinase and tyrosinase related proteinases [TRP-1, TRP-2]
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Applicants
  • SCANCELL LIMITED [GB]/[GB]
Inventors
  • DURRANT, Linda Gillian
  • VANKEMMELBEKE, Mireille
  • BRENTVILLE, Victoria
  • METHERINGHAM, Rachael
Agents
  • KILBURN & STRODE LLP
Priority Data
2013385.626.08.2020GB
2101435.202.02.2021GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NUCLEIC ACIDS ENCODING A POLYPEPTIDE COMPRISING A MODIFIED FC REGION OF A HUMAN IGG1 AND AT LEAST ONE HETEROLOGOUS ANTIGEN
(FR) ACIDES NUCLÉIQUES CODANT POUR UN POLYPEPTIDE COMPRENANT UNE RÉGION FC MODIFIÉE D'UNE IGG1 HUMAINE ET AU MOINS UN ANTIGÈNE HÉTÉROLOGUE
Abstract
(EN) The present invention relates to nucleic acids and peptides encoded by those nucleic acids. In particular, the peptides comprise a modified IgG1 Fc region and one or more heterologous epitopes, which may be B- or T-cell epitopes. A nucleic acid of the invention may encode a polypeptide comprising: (i) a modified Fc region of a human IgG1, and (i) at least one heterologous antigen, wherein (a) the modified Fc region comprises at least the part of Fc that is capable of binding to CD64 and/or TRIM21, (b) at least one residue of the Fc region is modified to the corresponding residue from a mouse IgG3 antibody and (c) the modified Fc region has enhanced avidity for Fc- gamma receptor (FcγR) when compared to the corresponding wildtype Fc region.
(FR) La présente invention concerne des acides nucléiques et des peptides codés par ces acides nucléiques. En particulier, les peptides comprennent une région Fc d'IgG1 modifiée et un ou plusieurs épitopes hétérologues, qui peuvent être des épitopes de lymphocytes B ou T. Un acide nucléique selon l'invention peut coder pour un polypeptide comprenant : (i) une région Fc modifiée d'une IgG1 humaine, et (ii) au moins un antigène hétérologue, (a) la région Fc modifiée comprenant au moins la partie de Fc qui est susceptible de se lier au CD64 et/ou au TRIM21, (b) au moins un résidu de la région Fc étant modifié par rapport au résidu correspondant d'un anticorps IgG3 de souris et (c) la région Fc modifiée présentant une avidité accrue pour le récepteur Fc-gamma (FcγR) par rapport à la région Fc de type sauvage correspondante.
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