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1. WO2022139582 - PROCESS FOR CONTROLLED MANUFACTURING OF MONO-DISPERSE MICROBUBBLES

Publication Number WO/2022/139582
Publication Date 30.06.2022
International Application No. PCT/NL2021/050785
International Filing Date 23.12.2021
IPC
A61K 49/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
CPC
A61K 49/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Applicants
  • SOLSTICE PHARMACEUTICALS B.V. [NL]/[NL]
Inventors
  • DE VARGAS SERRANO, Miguel
  • MANZI, Giuliana
Agents
  • JACOBS, Bart
Priority Data
202723727.12.2020NL
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR CONTROLLED MANUFACTURING OF MONO-DISPERSE MICROBUBBLES
(FR) PROCÉDÉ DE FABRICATION CONTRÔLÉE DE MICROBULLES MONODISPERSÉES
Abstract
(EN) The present invention relates to a process for preparing a hydrated phospholipids solvent mixture, by: - dissolving a first phospholipid at a temperature above the phase transition temperature of the phospholipids in an organic solvent to form a dissolved phospholipid solvent mixture; - dissolving a second phospholipid at a temperature above the phase transition temperature of the phospholipids in the dissolved phospholipid solvent mixture to form a dissolved phospholipids solvent mixture; - adding an aqueous phosphate buffer to the dissolved phospholipids solvent mixture to form a buffered phospholipids solvent mixture; and - stirring the buffered phospholipids solvent mixture to form a hydrated phospholipids solvent mixture.
(FR) La présente invention concerne un procédé de préparation d'un mélange de solvants de phospholipides hydratés comprenant les étapes consistant : à dissoudre un premier phospholipide à une température supérieure à la température de transition de phase des phospholipides dans un solvant organique pour former un mélange de solvants phospholipides dissous ; àbdissoudre un second phospholipide à une température supérieure à la température de transition de phase des phospholipides dans le mélange de solvants phospholipides dissous pour former un mélange de solvants phospholipides dissous ; à ajouter un tampon de phosphate aqueux au mélange de solvants de phospholipides dissous pour former un mélange de solvants de phospholipides tamponné ; et à agiter le mélange de solvants de phospholipides mis en tampon pour former un mélange de solvants de phospholipides hydratés.
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