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1. WO2022204084 - METHODS AND COMPOSITIONS FOR INHIBITING FORMATION OF THE HIV LATENT RESERVOIR

Publication Number WO/2022/204084
Publication Date 29.09.2022
International Application No. PCT/US2022/021259
International Filing Date 22.03.2022
IPC
A61K 31/167 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 31/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US]/[US]
Inventors
  • MARGOLIS, David
  • BROWNE, Edward
Agents
  • SCHWARTZMAN, Robert, A.
Priority Data
63/164,71123.03.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR INHIBITING FORMATION OF THE HIV LATENT RESERVOIR
(FR) PROCÉDÉS ET COMPOSITIONS POUR INHIBER LA FORMATION DU RÉSERVOIR LATENT DE VIH
Abstract
(EN) The present invention relates to methods for inhibiting human immunodeficiency virus (HIV) from entering latency in an infected subjected by co-administering an antiretroviral therapy regimen (ART) and a histone deacetylase (HDAC) inhibitor during a time window suitable for inhibiting entry into latency. The invention further relates to methods for treating HIV infections and compositions for carrying out the methods of the invention.
(FR) La présente invention concerne des procédés d'inhibition d'entrée en latence du virus de l'immunodéficience humaine (VIH) chez un sujet infecté par coadministration d'un régime de thérapie antirétrovirale (ART) et d'un inhibiteur d'histone désacétylase (HDAC) pendant une fenêtre temporelle appropriée pour inhiber l'entrée en latence. L'invention concerne en outre des procédés de traitement d'infections par le VIH et des compositions pour la mise en œuvre des procédés de l'invention.
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