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1. WO2022139418 - FATTY ACID-MODIFIED POLYMER NANOPARTICLES, AND USE THEREOF

Publication Number WO/2022/139418
Publication Date 30.06.2022
International Application No. PCT/KR2021/019527
International Filing Date 21.12.2021
IPC
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 47/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 33/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
10Carbonates; Bicarbonates
A61P 3/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61K 8/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
CPC
A61K 33/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof ; , e.g. clay
10Carbonates; Bicarbonates
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 8/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
A61K 8/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
19containing inorganic ingredients
A61K 8/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
36Carboxylic acids; Salts or anhydrides thereof
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
Applicants
  • (주)슈퍼노바 바이오 SUPERNOVA BIO CO., LTD. [KR]/[KR]
Inventors
  • 이근용 LEE, Kuen Yong
  • 이혜원 LEE, Hye Won
Agents
  • 특허법인 다나 DANA PATENT LAW FIRM
Priority Data
10-2020-018308524.12.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) FATTY ACID-MODIFIED POLYMER NANOPARTICLES, AND USE THEREOF
(FR) NANOPARTICULES DE POLYMÈRE MODIFIÉES PAR ACIDE GRAS ET LEUR UTILISATION
(KO) 지방산 도입 고분자 나노 입자 및 이의 용도
Abstract
(EN) The present invention relates to fatty acid-modified polymer nanoparticles, and a use thereof. In the present invention, nanoparticles having embedded calcium carbonate crystals can be formed using a biocompatible polymer and an adipocyte-targeting ligand (a fatty acid) to minimize delivery to surrounding cells and tissues other than adipocytes and maximize the embedding of the nanoparticles into adipocytes. The nanoparticles according to the present invention can be produced as an injectable preparation, and can be applied to local lipolysis supplements or diet and beauty products that break down localized fat.
(FR) La présente invention se rapporte à des nanoparticules de polymère modifiées par un acide gras et à leur utilisation. Dans la présente invention, des nanoparticules ayant des cristaux de carbonate de calcium incorporés peuvent être formées à l'aide d'un polymère biocompatible et d'un ligand ciblant les adipocytes (un acide gras) afin de réduire à un minimum l'administration aux cellules et tissus environnants autres que les adipocytes et de maximiser l'incorporation des nanoparticules dans les adipocytes. Les nanoparticules, selon la présente invention, peuvent être produites sous forme de préparation injectable, et peuvent être appliquées à des suppléments de lipolyse locaux ou à des produits de beauté de régime qui dégradent de la graisse localisée.
(KO) 본 발명은 지방산 도입 고분자 나노입자 및 이의 용도에 관한 것이다. 본 발명에서는 생체친화성 고분자 및 지방 세포 표적 리간드(지방산)을 이용하여 탄산칼슘 결정이 함입된 나노입자를 형성함으로써 지방 세포 이외의 주변 세포 및 조직으로 전달을 최소화하고 지방 세포 내로의 나노 입자의 함입을 최대화할 수 있다. 본 발명에 따른 나노 입자는 주사 가능한 제제로 제작 가능하고, 국소 지방을 분해하는 국소 지방 분해 보완재 또는 다이어트 미용 제품으로 적용될 수 있다.
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