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1. WO2022134245 - HEAT-CLEARING AND EXTERIOR SYNDROME-RELIEVING TRADITIONAL CHINESE MEDICINE COMPOSITION AND PREPARATION METHOD THEREFOR

Publication Number WO/2022/134245
Publication Date 30.06.2022
International Application No. PCT/CN2021/072050
International Filing Date 15.01.2021
IPC
A61K 36/815 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
815Lycium (desert-thorn)
A61K 33/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 47/40 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
40Cyclodextrins; Derivatives thereof
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
CPC
A61K 2236/331
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
33involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
331using water, e.g. cold water, infusion, tea, steam distillation, decoction
A61K 2236/333
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
33involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
333using mixed solvents, e.g. 70% EtOH
A61K 2236/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
39Complex extraction schemes, e.g. fractionation or repeated extraction steps
A61K 33/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof ; , e.g. clay
A61K 36/195
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
19Acanthaceae (Acanthus family)
195Strobilanthes
A61K 36/27
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
27Asclepiadaceae (Milkweed family), e.g. hoya
Applicants
  • 海南葫芦娃药业集团股份有限公司 HAINAN HULUWA PHARMACEUTICAL GROUP CO., LTD. [CN]/[CN]
Inventors
  • 刘景萍 LIU, Jingping
  • 刘全国 LIU, Quanguo
  • 陈克领 CHEN, Keling
  • 吴育强 WU, Yuqiang
  • 郑国菊 ZHENG, Guoju
  • 王家 WANG, Jia
  • 李党 LI, Dang
Agents
  • 海口汉普知识产权代理有限公司 HAIKOU HEIP INTELLECTUAL PROPERTY AGENCY CO., LTD
Priority Data
202011515830.X21.12.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HEAT-CLEARING AND EXTERIOR SYNDROME-RELIEVING TRADITIONAL CHINESE MEDICINE COMPOSITION AND PREPARATION METHOD THEREFOR
(FR) COMPOSITION DE MÉDECINE CHINOISE TRADITIONNELLE SOULAGEANT UN SYNDROME EXTERNE ET DISSIPANT LA CHALEUR ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种清热解表中药组合物及其制备方法
Abstract
(EN) A heat-clearing and exterior syndrome-relieving traditional Chinese medicine composition and a preparation method therefor. The preparation method comprises the following steps: extracting volatile oils from Herba Pogostemonis and Herba Menthae to obtain the volatile oils, and retaining a distilled aqueous solution for use; soaking Flos Chrysanthemi and Fructus Forsythiae in an aqueous ethanol solution, performing ultrasound extraction and filtration, retaining the herb residue for use, and recovering ethanol from the filtrate to obtain a clear paste; taking Folium Isatidis, Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Lycii, gypsum accounting for 75-85% of the amount thereof, and the herb residue, adding an aqueous ethanol solution for heat reflux extraction, mixing the extract solutions and filtering the mixture, after recovering ethanol from the filtrate, mixing the filtrate with the aqueous solution and the clear paste, and performing concentration to form a thick paste; taking the volatile oils to prepare a volatile oil inclusion compound; taking the remaining amount of gypsum and Radix Isatidis and crushing same into fine powder to obtain medicinal material fine powder, and sterilizing the medicinal material fine powder for later use; mixing the medicinal material fine powder with auxiliary materials, adding the thick paste, mixing uniformly, preparing particles, drying same, then adding the volatile oil inclusion compound, and mixing uniformly to obtain the composition. The present invention improves the contents of phillyrin and total flavonoids of Flos Chrysanthemi in the product, thereby improving the efficacy of the product.
(FR) L'invention concerne une composition de médecine chinoise traditionnelle soulageant un syndrome externe et dissipant la chaleur et son procédé de préparation. Le procédé de préparation comprend les étapes suivantes consistant à : extraire des huiles volatiles de Herba Pogostemonis et Herba Menthae pour obtenir les huiles volatiles, et réserver une solution aqueuse distillée pour une utilisation ; plonger Flos Chrysanthemi et Fructus Forsythiae dans une solution aqueuse d'éthanol, réaliser une extraction et une filtration par ultrasons, réserver le résidu d'herbe pour une utilisation, et récupérer l'éthanol à partir du filtrat pour obtenir une pâte claire ; prendre Folium Isatidis, Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Lycii, du gypse représentant 75 à 85 % de la quantité de ceux-ci, et le résidu d'herbe, ajouter une solution aqueuse d'éthanol pour l'extraction au reflux sous chauffage, mélanger les solutions d'extrait et filtrer le mélange, après récupération de l'éthanol à partir du filtrat, mélanger le filtrat avec la solution aqueuse et la pâte claire, et effectuer une concentration pour former une pâte épaisse ; prendre les huiles volatiles pour préparer un composé d'inclusion d'huile volatile ; prendre la quantité restante de gypse et de Radix Isatidis et les broyer en poudre fine pour obtenir une poudre fine de matière médicinale, et stériliser la poudre fine de matière médicinale pour une utilisation ultérieure ; mélanger la poudre fine de matière médicinale avec des matières auxiliaires, ajouter la pâte épaisse, mélanger uniformément, préparer des particules, sécher celles-ci, puis ajouter le composé d'inclusion d'huile volatile, et mélanger uniformément pour obtenir la composition. La présente invention améliore les teneurs en phillyrine et flavonoïdes totaux de Flos Chrysanthemi dans le produit, ce qui permet d'améliorer l'efficacité du produit.
(ZH) 一种清热解表中药组合物及其制备方法,包括以下步骤:取广藿香、薄荷提取挥发油,得挥发油,蒸馏后的水溶液留用;取菊花、连翘加乙醇水溶液浸泡,超声提取,滤过,药渣留用,滤液回收乙醇,得清膏;取大青叶、地黄、白薇、地骨皮、处方量75~85%的石膏以及上述的药渣,加乙醇水溶液加热回流提取,合并提取液,滤过,滤液回收乙醇后与上述水溶液和清膏合并,浓缩为稠膏;取上述的挥发油制备挥发油包合物;取余量石膏、板蓝根粉碎成细粉,得药材细粉,灭菌后备用;取上述药材细粉与辅料混匀,加入稠膏,混匀,制颗粒,干燥后加入挥发油包合物,混匀,即得。本发明提高了产品中连翘苷、菊花总黄酮含量,提高了产品的疗效。
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