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1. WO2022133555 - SOLID PHARMACEUTICAL COMPOSITION CONTAINING VITAMIN D AND CALCIUM SALT, METHOD FOR TREATING OR PREVENTING CONDITIONS RELATED TO LOW INGESTION OF AND/OR HIGHER NEED FOR CALCIUM, USE OF THE SOLID PHARMACEUTICAL COMPOSITION, AND PHARMACEUTICAL PRODUCT OR SUPPLEMENT

Publication Number WO/2022/133555
Publication Date 30.06.2022
International Application No. PCT/BR2020/050581
International Filing Date 23.12.2020
IPC
A61K 36/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
02Algae
04Rhodophycota or rhodophyta (red algae), e.g. Porphyra
A61K 31/59 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9,10-seco-cyclopentahydro- phenanthrene ring systems
A61K 31/592 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9,10-seco-cyclopentahydro- phenanthrene ring systems
5929,10-Secoergostane derivatives, e.g. ergocalciferol, vitamin D2
A61K 31/593 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9,10-seco-cyclopentahydro- phenanthrene ring systems
5939,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
A61K 33/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
10Carbonates; Bicarbonates
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
CPC
A61K 31/59
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
A61K 31/592
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
A61K 31/593
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
A61K 33/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof ; , e.g. clay
10Carbonates; Bicarbonates
A61K 36/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
02Algae
04Rhodophycota or rhodophyta (red algae), e.g. Porphyra
A61K 9/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Applicants
  • LITHOCÁLCIO INDÚSTRIA, COMÉRCIO, IMPORTAÇÃO, EXPORTAÇÃO E REPRESENTAÇÃO LTDA. [BR]/[BR]
  • UNIVERSIDADE DE SÃO PAULO - USP [BR]/[BR]
Inventors
  • PEREIRA DA SILVA, Rosana
  • GOMES FERRAZ, Humberto
Agents
  • FERREIRA EVANGELISTA, Katia Jane
  • CALABRIA MATTIOLI DANTAS, Paola
  • MEYER GAIARSA, Veronica
Priority Data
Publication Language Portuguese (pt)
Filing Language Portuguese (PT)
Designated States
Title
(EN) SOLID PHARMACEUTICAL COMPOSITION CONTAINING VITAMIN D AND CALCIUM SALT, METHOD FOR TREATING OR PREVENTING CONDITIONS RELATED TO LOW INGESTION OF AND/OR HIGHER NEED FOR CALCIUM, USE OF THE SOLID PHARMACEUTICAL COMPOSITION, AND PHARMACEUTICAL PRODUCT OR SUPPLEMENT
(FR) COMPOSITION PHARMACEUTIQUE SOLIDE CONTENANT DE LA VITAMINE D ET DU SEL DE CALCIUM, PROCÉDÉ POUR TRAITER OU PRÉVENIR DES CONDITIONS LIÉES À UNE FAIBLE INGESTION ET/OU À UN PLUS GRAND BESOIN EN CALCIUM, UTILISATION DE LA COMPOSITION PHARMACEUTIQUE SOLIDE ET PRODUIT PHARMACEUTIQUE OU SUPPLÉMENTAIRE
(PT) COMPOSIÇÃO FARMACÊUTICA SÓLIDA CONTENDO VITAMINA D E SAL DE CÁLCIO, MÉTODO PARA TRATAR OU PREVENIR CONDIÇÕES RELACIONADAS A BAIXA INGESTÃO E/OU MAIOR NECESSIDADE DE CÁLCIO, USO DA COMPOSIÇÃO FARMACÊUTICA SÓLIDA E PRODUTO FARMACÊUTICO OU SUPLEMENTAR
Abstract
(EN) The present invention describes a solid pharmaceutical composition including an external coating containing immediate-release vitamin D, and a matrix containing prolonged-release vitamin D and calcium salt, having the technical effect of improving calcium absorption, since it enables suitable concentrations of vitamin D in the blood throughout the release of calcium, which reduces the quantity of calcium excreted in faeces and improves the effectiveness of treatments for osteoporosis and other illnesses related to inadequate concentrations of calcium in the blood. The composition of the present invention can also be provided as mini-pills to facilitate administration by mouth, and also to modulate the quantity of calcium and vitamin D consumed by the patient/user. The present invention describes a solid pharmaceutical composition, a method for treating or preventing conditions related to low ingestion of and/or higher need for calcium, use of the solid pharmaceutical composition, and a pharmaceutical product or supplement. The present invention pertains to the field of medical preparations containing organic and inorganic active substances.
(FR) La présente invention concerne une composition pharmaceutique solide contenant un revêtement externe de libération immédiate de vitamine D, et une matrice à libération prolongée de vitamine D et de sel de calcium, ladite composition permettant un effet technique pour une absorption de calcium améliorée, puisqu'elle permet des concentrations adéquates de vitamine D dans le sang pendant toute la durée de libération du calcium, ce qui diminue la quantité de calcium rejeté par les fèces, et qu'elle permet d'améliorer l'efficacité du traitement de l'ostéoporose et d'autres maladies liées à une carence calcique du sang. La composition de la présente invention peut aussi se présenter sous forme de mini-comprimés pour favoriser une administration facilitée par voie orale ainsi que permettre de moduler la quantité de calcium ou de vitamine D que le patient/consommateur va consommer. La présente invention concerne une composition pharmaceutique solide, un procédé pour traiter ou prévenir des troubles pathologiques liées à une faible ingestion de calcium et/ou à un plus grand besoin en calcium, l'utilisation de la composition pharmaceutique et le produit pharmaceutique ou supplémentaire. La présente invention se situe dans le domaine des préparations médicales contenant des ingrédients actifs organiques et non organiques.
(PT) A presente invenção tem por objetivo descrever sobre uma composição farmacêutica sólida contendo um revestimento externo de liberação imediata de vitamina D, e matriz com liberação prolongada de vitamina D e sal de cálcio, que permite um efeito técnico para melhorada absorção do cálcio, pois possibilita adequadas concentrações de vitamina D no sangue durante toda a liberação do cálcio, o que diminui a quantidade de cálcio excreto pelas fezes e possibilita melhorar a eficácia no tratamento de osteoporose e outras doenças relacionadas a deficiência na concentração cálcio no sangue. A composição da presente invenção pode ainda ser apresentada na forma de minicomprimidos, para promover uma facilitada administração pela via oral, como também permitir modular a quantidade de cálcio e vitamina D que o paciente/consumidor irá consumir. A presente invenção descreve sobre uma composição farmacêutica sólida, método para tratar ou prevenir condições relacionadas a baixa ingestão e/ou maior necessidade de cálcio, uso da composição farmacêutica e produto farmacêutico ou suplementar. A presente invenção se situa no campo de preparações médicas contendo ingredientes ativos orgânicos e inorgânicos.
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