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1. WO2021188966 - SARS-COV-2 SPIKE PROTEIN BINDING PEPTIDES

Publication Number WO/2021/188966
Publication Date 23.09.2021
International Application No. PCT/US2021/023262
International Filing Date 19.03.2021
IPC
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07H 21/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
C07K 14/435 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/40 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40against enzymes
CPC
C12N 9/485
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
485Exopeptidases (3.4.11-3.4.19)
C12Y 304/17023
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
17Metallocarboxypeptidases (3.4.17)
17023Angiotensin-converting enzyme 2 (3.4.17.23)
Applicants
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US]/[US]
Inventors
  • PENTELUTE, Bradley L.
  • ZHANG, Genwei
  • POMPLUN, Sebastian
  • LOFTIS, Alexander R.
  • LOAS, Andrei
Agents
  • LABEOTS, Laura
Priority Data
62/991,88619.03.2020US
63/016,92528.04.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SARS-COV-2 SPIKE PROTEIN BINDING PEPTIDES
(FR) PEPTIDES SE LIANT AUX PROTÉINES DE SPICULE DU SRAS-COV-2
Abstract
(EN) The disclosure provides peptides that are useful for the prevention of infection of coronaviruses, especially SARS-CoV-2. Also described is a method reducing probability of viral infection in a human subject, comprising administering a therapeutically effective amount of the pharmaceutical composition described herein.
(FR) L'invention concerne des peptides qui sont utiles pour la prévention d'une infection par des coronavirus, en particulier le SARS-CoV 2. L'invention concerne une méthode de réduction de la probabilité d'une infection virale chez un sujet humain, comprenant l'administration d'une quantité thérapeutiquement efficace de la composition pharmaceutique décrite dans la description.
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