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1. WO2022210066 - ANTIDRUG ANTIBODY MEASUREMENT METHOD

Publication Number WO/2022/210066
Publication Date 06.10.2022
International Application No. PCT/JP2022/012965
International Filing Date 22.03.2022
IPC
C12Q 1/68 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • 積水メディカル株式会社 SEKISUI MEDICAL CO., LTD. [JP]/[JP]
Inventors
  • 関野 哲男 SEKINO Tetsuo
  • 大森 茜 OOMORI Akane
Agents
  • 弁理士法人 もえぎ特許事務所 MOEGI PATENT ATTORNEYS
Priority Data
2021-06150731.03.2021JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTIDRUG ANTIBODY MEASUREMENT METHOD
(FR) PROCÉDÉ DE MESURE D'ANTICORPS ANTI-MÉDICAMENT
(JA) 抗薬物抗体測定方法
Abstract
(EN) Provided is a measurement method for antidrug antibodies that is easier and lower-cost compared with conventional methods. Provided is a double antigen bridging immunoassay method using a capture nucleic acid and a tracer nucleic acid. By using the capture nucleic acid and the tracer nucleic acid in the double antigen bridging immunoassay method, it is possible to measure antidrug antibodies easily and at a lower cost. Moreover, by using the tracer nucleic acid, it becomes possible to employ a nucleic acid–utilizing high-sensitivity detection method.
(FR) La présente invention concerne un procédé de mesure des anticorps anti-médicament plus facile et moins coûteux que les procédés conventionnels. L'invention concerne un procédé d'immunoessai de pontage à double antigène utilisant un acide nucléique de capture et un acide nucléique traceur. L'utilisation de l'acide nucléique de capture et de l'acide nucléique traceur dans le procédé d'immunoessai de pontage à double antigène permet de mesurer facilement et à moindre coût des anticorps anti-médicament. De plus, en utilisant l'acide nucléique traceur, il devient possible d'utiliser un acide nucléique en utilisant un procédé de détection haute sensibilité.
(JA) 従来法と比較して、簡便かつ安価な抗薬物抗体の測定法を提供する。 捕獲核酸及びトレーサー核酸を使用する二重抗原架橋イムノアッセイ法を提供する。二重抗原架橋イムノアッセイ法において捕獲核酸及びトレーサー核酸を使用することにより、抗薬物抗体の測定を簡便かつ安価に行うことができる。また、トレーサー核酸を使用することにより、核酸を利用した高感度検出方法を採用することが可能になる。
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