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1. WO2022207832 - CAPTURE CONSTRUCT AND METHOD FOR DETECTING A PLURALITY OF ANALYTES

Publication Number WO/2022/207832
Publication Date 06.10.2022
International Application No. PCT/EP2022/058640
International Filing Date 31.03.2022
IPC
C12Q 1/6825 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6825Nucleic acid detection involving sensors
C12Q 1/6816 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
C12Q 1/6816
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
C12Q 1/6825
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6825Nucleic acid detection involving sensors
Applicants
  • LEICA MICROSYSTEMS CMS GMBH [DE]/[DE]
Inventors
  • ALSHEIMER, Soeren
  • GISKE, Arnold
Agents
  • SCHAUMBURG UND PARTNER PATENTANWÄLTE MBB
Priority Data
PCT/EP2021/05878501.04.2021EP
PCT/EP2021/06175404.05.2021EP
PCT/EP2021/06331019.05.2021EP
PCT/EP2021/06664518.06.2021EP
PCT/EP2021/07381928.08.2021EP
PCT/EP2021/07441203.09.2021EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CAPTURE CONSTRUCT AND METHOD FOR DETECTING A PLURALITY OF ANALYTES
(FR) CONSTRUCTION DE CAPTURE ET PROCÉDÉ DE DÉTECTION D'UNE PLURALITÉ D'ANALYTES
Abstract
(EN) A capture construct (100, 1000) is provided for capturing a plurality of analytes (402, 504, 604, 706) of a biological sample (1300, 1408). The capture construct (100, 1000) comprises a nanostructure backbone (102), at least a first orientation indicator (104) and a second orientation indicator (106), and at least a first plurality of capture regions (108a-108f) on the nanostructure backbone (102), each capture region (108a-108f) comprising at least one affinity capture reagent (400, 502, 602, 702, 704) configured to capture one of the analytes (402, 504, 604, 706). In a further aspect a method is provided for detecting a plurality of analytes (402, 504, 604, 706) of a biological sample (1300, 1408).
(FR) La présente invention concerne une construction de capture (100, 1000) pour capturer une pluralité d'analytes (402, 504, 604, 706) dans un échantillon biologique (1300, 1408). La construction de capture (100, 1000) comprend un squelette à nanostructure (102), au moins un premier indicateur d'orientation (104) et un second indicateur d'orientation (106), et au moins une première pluralité de régions de capture (108a-108f) sur le squelette à nanostructure (102), chaque région de capture (108a-108f) comprenant au moins un réactif de capture d'affinité (400, 502, 602, 702, 704) conçu pour capturer l'un des analytes (402, 504, 604, 706). Dans un autre aspect, l'invention concerne un procédé de détection d'une pluralité d'analytes (402, 504, 604 706) dans échantillon biologique (1300, 1408).
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