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1. WO2021248087 - ENZYMES AND REGULATORY PROTEINS IN TRYPTAMINE METABOLISM

Publication Number WO/2021/248087
Publication Date 09.12.2021
International Application No. PCT/US2021/036031
International Filing Date 04.06.2021
IPC
C12N 9/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
C12N 15/09 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12N 15/52 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
Applicants
  • CB THERAPEUTICS, INC. [US]/[US]
Inventors
  • PEIFFER, Laura Flatauer
  • VOGAN, Jacob Michael
  • WADE, James Lee
  • YACOUB, Tyrone Jacob
  • TANG, Kirsten
  • BURNETT, Rachel Nadine
Agents
  • GENDLOFF, Elie, H.
Priority Data
63/035,69206.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ENZYMES AND REGULATORY PROTEINS IN TRYPTAMINE METABOLISM
(FR) ENZYMES ET PROTÉINES RÉGULATRICES DANS LE MÉTABOLISME DE LA TRYPTAMINE
Abstract
(EN) Provided are non-naturally occurring nucleic acids comprising a sequence encoding an enzyme or regulatory protein in tryptamine metabolism. Also provided are a recombinant microorganisms expressing the enzyme or regulatory protein. Methods of expressing the enzyme or regulatory protein are additionally provided.
(FR) L'invention concerne des acides nucléiques d'origine non naturelle comprenant une séquence codant pour une enzyme ou une protéine régulatrice dans le métabolisme de la tryptamine. L'invention concerne également des micro-organismes recombinés exprimant l'enzyme ou la protéine régulatrice. L'invention concerne en outre des procédés d'expression de l'enzyme ou de la protéine régulatrice.
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