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IC_EX:A61K39/44

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Analysis

1 / 408
1.WO/2025/136325VEGFR-2 TARGETED ANTIBODY-DRUG CONJUGATE EFFECTIVE IN THE TREATMENT OF OVARIAN CANCER
WO - 26.06.2025
Int.Class A61K 39/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
 Appl.No PCT/TR2024/051602 Applicant DOKUZ EYLUL UNIVERSITESI REKTORLUGU Inventor AYAR KAYALI, Hulya
The invention relates to VEGFR-2 targeted antibody-drug conjugates comprising the monoclonal antibody, Ramucirumab, conjugated to a therapeutic agent (MMAE) with a cleavable maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl linker in the presence of cathepsin, for use in the treatment of ovarian cancer. The VEGFR-2 targeted antibody drug conjugates (ADCs) of the invention can also be used for the treatment of other types of cancer other than ovarian cancer expressing target receptors.
2.4572799ANTIBODY-DRUG CONJUGATES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS
EP - 25.06.2025
Int.Class A61K 47/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
 Appl.No 23854404 Applicant SHANGHAI RUOTUO BIOSCIENCES CO LTD Inventor FU HONG

Provided herein are antibody-drug conjugates, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease. Additionally, provided herein are functionalized compounds, for example, a compound of Formula (IA), for conjugation with an antibody.

3.2025114165АНТИ-CCR8 АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
RU - 19.06.2025
Int.Class A61K 39/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
 Appl.No 2025114165 Applicant БАЙОСИТОДЖЕН ФАРМАСЬЮТИКАЛЗ (БЕЙДЖИН) КО., ЛТД. (CN) Inventor ИНЬ, Мэймэй (CN)
4.20250186585COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
US - 12.06.2025
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
 Appl.No 19063828 Applicant MEMORIAL SLOAN-KETTERING CANCER CENTER Inventor Christopher C. Kloss

The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

5.4565281SITE-SPECIFIC MODIFICATION BY A BBB-SHUTTLE OF ANTIBODY-BASED ENTITIES FOR CROSSING THE BLOOD-BRAIN BARRIER
EP - 11.06.2025
Int.Class A61K 47/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
 Appl.No 23750999 Applicant GATE2BRAIN S L Inventor SÁNCHEZ NAVARRO MACARENA

Conjugates of antibodies and selected peptide shuttles that cross the blood-brain barrier, optionally, also conjugated with an active pharmaceutical ingredient, radiotherapy agent or diagnostic agent, pharmaceutical compositions comprising them, as well as the conjugates for use in medicine and as a diagnostic agent.

6.120112311抗原结合蛋白
CN - 06.06.2025
Int.Class A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
 Appl.No 202380075380.2 Applicant VIIV保健英国第五有限公司 Inventor E·阿诺尔特
本发明的抗原结合蛋白与人免疫缺陷病毒(HIV)包膜蛋白结合，并且用于治疗和预防HIV感染。特别地，抗原结合蛋白与HIV包膜表面糖蛋白120(gp120)上的两个不同表位(V3环区和CD4结合位点)结合。
7.20250177523MULTISPECIFIC ANTIGEN-BINDING PROTEINS
US - 05.06.2025
Int.Class A61K 39/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
 Appl.No 18915061 Applicant Genentech, Inc. Inventor Paul CARTER

Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

8.WO/2025/114429TRANSCYTOSING COMPOSITION
WO - 05.06.2025
Int.Class C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
 Appl.No PCT/EP2024/083901 Applicant INTRACT PHARMA LTD Inventor KLEIJNEN, Maurits
The present invention relates to transporter proteins capable of transcytosing the intestinal wall and delivering antibodies to the blood stream.
9.320413ANTIGEN BINDING PROTEINS
IL - 01.06.2025
Int.Class A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
 Appl.No 320413 Applicant VIIV HEALTHCARE UK (NO.5) LIMITED Inventor ARNOULT, Eric
10.120060307一种基于血液循环肺脏原位生物合成免疫检查点阻断剂的工程菌及其应用
CN - 30.05.2025
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
 Appl.No 202510224654.0 Applicant 徐州医科大学 Inventor 张昊
本发明公开了一种基于血液循环肺脏原位生物合成免疫检查点阻断剂的工程菌及其应用，属于生物技术和医药技术领域。本发明公开的一种基于血液循环肺脏原位生物合成免疫检查点阻断剂的工程菌，含有p15A‑J23119‑csgA‑anti‑PD‑L1nanobody质粒；工程菌在其细菌表面展示出anti‑PD‑L1nanobody，阻断PD‑L1与T细胞表面PD‑1的结合，解除免疫抑制信号，恢复T细胞对肿瘤细胞的杀伤功能。利用工程益生菌的天然乏氧趋向性，增强对肺脏肿瘤部位的靶向性，实现精准化治疗。
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