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IC:G01N33/569

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Analysis

1.WO/2020/185464FILOVIRUS ANTIBODIES AND METHODS
WO 17.09.2020
Int.Class A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
Appl.No PCT/US2020/020982 Applicant STC.UNM Inventor DURVASULA, Ravi
An antibody that binds to a filovirus glycoprotein generally includes include a complementarity determining region (CDR) of any one of SEQ ID NO:27-36 or a combination of such CDRs. The antibody may be used in to detect filovirus in a biological sample obtained from a subject. The antibody also may be formulated into a pharmaceutical composition for administering to a subject having, or at risk of having, a filovirus infection.
2.WO/2020/184911MARKER FOR PREDICTING TUMOR REACTIVITY OF LYMPHOCYTES, AND USE THEREOF
WO 17.09.2020
Int.Class C12Q 1/6881
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6881for tissue or cell typing, e.g. human leukocyte antigen probes
Appl.No PCT/KR2020/003157 Applicant THE ASAN FOUNDATION Inventor LEE, Hee Jin
The present invention relates to a marker for predicting tumor reactivity of lymphocytes, a composition for predicting tumor reactivity, and a method for predicting tumor reactivity. According to the present invention, a predictive model capable of predicting tumor reactivity of cultured lymphocytes can be constructed using a genetic marker, and through the predictive model, the reactivity of lymphocytes is predicted so as to more accurately select lymphocytes specific to a tumor and produce an effective immunotherapeutic agent. In addition, the use of the genetic marker enables lymphocytes to be separated more easily from tissues, blood, or body fluids in a body using non-invasive methods different from conventional invasive methods, and enables only lymphocytes with tumor-specific activity to be selected and used for immunotherapy. Therefore, the present invention is expected to have a wide range of applications.
3.10775377Methods for assaying cellular binding interactions
US 15.09.2020
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No 16912288 Applicant The University of British Columbia Inventor Anupam Singhal

There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.

4.10775378Methods for assaying cellular binding interactions
US 15.09.2020
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No 16912488 Applicant The University of British Columbia Inventor Anupam Singhal

There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.

5.WO/2020/178567METHODS OF SCREENING AND COMPOUNDS FOR ADVERSE RESPONSE TO AN IMPLANT
WO 10.09.2020
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No PCT/GB2020/050497 Applicant PXD LIMITED Inventor LANGTON, David
Methods of screening a subject to determine whether or not they are at risk of having an adverse reaction to metal debris (ARMD), also known as adverse local tissue reaction (ALTR), methods of screening compounds for use in preventing or ameliorating such an adverse response and compounds for use in treating a subject.
6.20200282010IMMUNOGENIC COMPOSITIONS AND USES THEREFOR
US 10.09.2020
Int.Class A61K 38/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
Appl.No 16762877 Applicant Epiaxis Therapeutics Pty Ltd Inventor Sudha RAO

The present invention discloses the use of protein kinase C (PKC-θ) inhibitors for enhancing the immune effector function of functionally repressed T-cells that have undergone epithelial to mesenchymal transition (EMT). In specific embodiments, PKC-θ inhibitors are disclosed for use in enhancing susceptibility of exhausted T-cells to reinvigoration by PD-1 binding antagonists. The compositions of the present invention find utility in treating a range of disorders including T-cell dysfunctional disorders such as pathogenic infections and hyperproliferative disorders.

7.WO/2020/178816KITS, COMPOSITIONS AND METHODS FOR EVALUATING IMMUNE SYSTEM STATUS
WO 10.09.2020
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Appl.No PCT/IL2020/050235 Applicant THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD. Inventor MONSONEGO, Alon
The present disclosure generally relates to the field of evaluating a status, in particular, an age of an immune system based on a level of biomarkers, the biomarkers indicative of CD4 T cell phenotype, specifically for identifying levels of CD4 cytotoxic cells and/or activated regulatory (a Treg) CD4 T cells and thereby identify diseases and disorders, such as, systemic inflammation.
8.WO/2020/179303PATHOGEN DETECTION DEVICE AND PATHOGEN DETECTION METHOD
WO 10.09.2020
Int.Class G01N 21/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
Appl.No PCT/JP2020/003633 Applicant PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD. Inventor HARA Kohei
A pathogen detection device (10) comprises: an acquisition unit (11) for measuring the body temperature of a subject and outputting information indicating the body temperature; a collection unit (12) for collecting a pathogen carried by the subject or a pathogen in the air surrounding the subject; a detection unit (13) for detecting the pathogen collected by the collection unit (12); a communication unit (15) for communicating a detection result from the detection unit (13); and a control unit (14). The control unit (14) controls the detection unit (13) such that the detection unit (13) carries out pathogen detection again if the body temperature output by the acquisition unit exceeds a prescribed threshold and the detection result from the detection unit (13) is negative.
9.WO/2020/180713DESIGN, MANUFACTURE, AND USE OF PERSONALIZED CANCER VACCINES
WO 10.09.2020
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/US2020/020458 Applicant FLOW PHARMA, INC. Inventor RUBSAMEN, Reid M.
Personalized cancer vaccines are created by predicting whether a first neoantigen or a second neoantigen of an individual cancer patient has a stronger binding affinity for a human leukocyte antigen (HLA) complex of the patient and creating a particle containing the neoantigen with the stronger predicted binding affinity. Such a predicting step includes artificial intelligence, statistical modeling, or a combination thereof. Such a particle is created by encapsulating the neoantigen with the stronger predicted binding affinity for the HLA complex of the patient in a material. Placing the antigen in a particular sized particle is referred to here as Size Exclusion Antigen Presentation Control, (SEAPAC) used in methods of treating the patient using such a personalized cancer vaccine.
10.20200281930HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS
US 10.09.2020
Int.Class A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
Appl.No 16654582 Applicant FOUNDATION MEDICINE, INC. Inventor Chris Hendrik Boshoff

Methods of treating a head and neck cancer are disclosed.