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Analysis

1.WO/2020/235607METHOD FOR DETECTING TARGET MOLECULE
WO 26.11.2020
Int.Class G01N 37/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37Details not covered by any other group of this subclass
Appl.No PCT/JP2020/019992 Applicant TOPPAN PRINTING CO., LTD. Inventor HIRASE Takumi
This method for detecting a surface target molecule and an internal target molecule of a structure comprises steps for: bringing a liquid having a structure dispersed therein into contact with a well array having a plurality of wells so as to introduce the structure into the wells; bringing an encapsulation liquid into contact with the well array so as to cause the structure to be encapsulated within each of the wells; extracting content of the structure within each of the wells; detecting at least one type of surface target molecule present on the surface of the structure within each of the wells; and detecting at least one type of internal target molecule present inside the structure within each of the wells.
2.WO/2020/235767BIOMARKER FOR DIAGNOSIS OR PREDICTION OF POST-TRAUMATIC STRESS DISORDER, AND USE THEREOF
WO 26.11.2020
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/KR2020/000767 Applicant EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION Inventor LYOO, In Kyoon
The present invention relates to a biomarker for diagnosis or prediction of post-traumatic stress disorder, and a use thereof and, more particularly, to a method of providing information for diagnosis or prediction of post-traumatic stress disorder by using the biomarker.
3.WO/2020/235827METHOD FOR PROVIDING INFORMATION ABOUT THERAPEUTIC RESPONSE TO ANTICANCER IMMUNOTHERAPY, AND KIT USING SAME
WO 26.11.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/KR2020/005625 Applicant INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY Inventor KIM, Hye Ryun
The present specification provides a method for providing information about a therapeutic response to anticancer immunotherapy, and a kit for providing information by using same, the method comprising the steps of: measuring DNA methylation of pDMRs in a biological sample isolated from an individual; and evaluating the therapeutic reaction to anticancer immunotherapy for the individual on the basis of the measured DNA methylation of pDMRs.
4.WO/2020/236087NUCLEIC ACID ANALYSIS
WO 26.11.2020
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/SG2020/050301 Applicant AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH Inventor GOH, Wee Siong
The present invention relates to a method for analysis of methylation of ribonucleic acid (RNA) comprising the steps: (i) contacting RNA with one or more antibodies which binds to methylated site(s) of RNA; wherein the methylated site(s) comprise at least one ribonucleotide base modified by one or more methyl groups; (ii) photo-crosslinking the one or more antibodies to crosslink individual antibodies to the RNA molecule(s) to form RNA-antibody conjugates; (iii) immunoprecipitating to separate the RNA-antibody conjugates; (iv) treating the RNA-antibody conjugates with at least one exonuclease; (v) removing the crosslinked antibodies from the RNA-antibody conjugates to release RNA; and (vi) analysing the released RNA.
5.WO/2020/237017METHODS USING PHOTOTHERMAL NANOPARTICLES IN RAPID NUCLEIC ACID AMPLIFICATION AND PHOTOTHERMAL NANOPARTICLES
WO 26.11.2020
Int.Class A61K 9/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
Appl.No PCT/US2020/033940 Applicant PROMEGA CORPORATION Inventor ZENG, Zhiyang
Methods using photothermal nanoparticles in rapid nucleic acid amplification and photothermal nanoparticles include forming a reaction mixture comprising a nucleic acid template, a polymerase enzyme, and a heating media. The heating media comprises a plurality of photothermal nanoparticles suspended in a solution, fabricated on a microchip, or on a surface of a well in a multi-well plate. The photothermal nanoparticles are nanoparticles having a particular geometric shape and comprise a single component or a multi-component. The plurality of photothermal nanoparticles are further categorized by surface plasmon resonance with a resonance wavelength in a particular range to convert energy absorbed from a light source to sufficiently heat a volume of a composition for the transcription of the new nucleic acid strand. The particular geometric shape of the photothermal nanoparticles is selected from the group consisting of: polyhedral, spheroid, torus, and hollow shapes.
6.WO/2020/237237METHODS FOR DETECTING A LEVEL OF H. PYLORI IN A FECAL SAMPLE
WO 26.11.2020
Int.Class G16B 30/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
30ICT specially adapted for sequence analysis involving nucleotides or amino acids
Appl.No PCT/US2020/034508 Applicant AMERICAN MOLECULAR LABORATORIES, INC. Inventor ZHOU, Yi
The present disclosure provides methods and materials for detecting a level of H. pylori in a sample.
7.WO/2020/236846METHODS AND RELATED KITS FOR SPATIAL ANALYSIS
WO 26.11.2020
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No PCT/US2020/033658 Applicant ENCODIA, INC. Inventor CHEE, Mark, S.
Provided herein are methods and compositions for spatial analysis of macromolecules (e.g., proteins, polypeptides, or peptides). In some embodiments, the methods are for analyzing a macromolecule or a plurality of macromolecules, (e.g., peptides, polypeptides, and proteins) including determining spatial information and sequencing the macromolecule. In some embodiments, the analysis employs barcoding and/or nucleic acid encoding of molecular recognition events, and/or detectable labels. Also provided are compositions, e.g., kits, containing components for performing the provided methods for analysis of the macromolecule.
8.WO/2020/232635METHOD AND SYSTEM FOR CONSTRUCTING SEQUENCING LIBRARY ON THE BASIS OF METHYLATED DNA TARGET REGION, AND USE THEREOF
WO 26.11.2020
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/CN2019/087824 Applicant MGI TECH CO., LTD. Inventor YANG, Lin
Disclosed are a method and a system for constructing a sequencing library on the basis of a methylated DNA target region, and a use thereof. The method comprises: obtaining a DNA sample that has been subjected to bisulfite conversion and that comprises a universal sequence; conducting amplification with first specific primers and first universal primers, the first specific primers being located upstream of the target region, and the first universal primers at least partly matching or overlapping the universal sequence; and conducting amplification with second specific primers, second universal primers and labeled primers to obtain the sequencing library; wherein the second specific primers are located downstream of the first specific primers and upstream of the target region, the second universal primers overlap at least part of the sequence of the second specific primers, and the labeled primers overlap part of the sequence of the first universal primer; or, the second specific primers are located downstream of the target region, the second universal primers overlap at least part of the sequence of the first specific primers, and the labelled primers overlap part of the sequence of the second specific primers.
9.WO/2020/234555METHODS RELATING TO TUBERCULOSIS
WO 26.11.2020
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/GB2020/050524 Applicant PBD BIOTECH LIMITED Inventor SWIFT, Benjamin
The invention relates to a method of diagnosis of tuberculosis (TB)disease in asubject. The method comprises admixing a Mycobacteria-specific bacteriophage with asample of peripheral blood mononuclear cells(PBMCs) from the subject, followed by determination of the presence or absence of a Mycobacterial DNA sequence in DNA isolated from the admixture. The invention provides a sensitive and specific test for the presence of incipient TB, i.e. an asymptomatic infectionwith a high risk of developing active TB, or for the presence oflatent tuberculosis infection(LTBI), i.e. an asymptomatic infection that is not likely to develop into active TB, in a subject.
10.WO/2020/234605METHOD OF QUALITY CONTROL OF OLIGONUCLEOTIDE SYNTHESIS
WO 26.11.2020
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
Appl.No PCT/GB2020/051250 Applicant NUCLERA NUCLEICS LTD Inventor CHEN, Michael Chun Hao
The invention relates to methods and compositions for the ensuring the quality of oligonucleotide synthesis during cycles of template independent terminal transferase extension. The amount of incorporated nucleotide can be determined for each cycle of extension, thereby confirming that the supplied nucleotide has efficiently incorporated to extend the strand.