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Analysis

1.WO/2020/181947METHOD FOR DETECTING ONE OR MORE TARGET NUCLEIC ACID SEQUENCES TO BE TESTED BY SINGLE TUBE AND KIT THEREOF
WO 17.09.2020
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
Appl.No PCT/CN2020/074925 Applicant JIANGSU MACRO&MICRO-TEST MED-TECH CO., LTD. Inventor LIU, Licheng
Provided are a method for detecting one or more target nucleic acid sequences to be tested by a single tube and a kit thereof. The method comprises the steps of: designing specific isothermal amplification primers and fluorescent probe RNHPs for each target nucleic acid sequence to be tested, and labeling the fluorescent probe RNHPs for each target nucleic acid sequence to be tested with different fluorescences; in the presence of a ribonuclease RNaseH, isothermally amplifying each target nucleic acid sequence to be tested under the action of a nucleic acid polymerase; and forming hybridization chain products labeled with different fluorescences by means of different target nucleic acid sequences to be tested, thereby achieving multiplex detection of a plurality of target nucleic acid sequences to be tested. In the present invention, on the basis of an isothermal amplification technique, real-time multiplex isothermal detection can be achieved just by introducing a special probe RNHP and combining same with RNaseH2.
2.WO/2020/182517CANCER DIAGNOSIS AND PROGNOSIS
WO 17.09.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/EP2020/055437 Applicant ONCOLAB DIAGNOSTICS GMBH Inventor ZEILLINGER, Robert
A method of identifying an SCLC patient at risk of disease progression comprising determining the expression of at least one marker selected from a neuroendocrine marker and/or DLLS in a blood sample or blood sample fraction of said patient, wherein said at least one marker is indicative of the patient's prognosis.
3.WO/2020/183437SYSTEMS AND METHODS FOR SPECTRAL DETECTION OF DRUG-RESISTANT PATHOGENS
WO 17.09.2020
Int.Class C12Q 1/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
18Testing for antimicrobial activity of a material
Appl.No PCT/IB2020/052339 Applicant MONASH UNIVERSITY Inventor HERAUD, Philip Robert
Methods of determining the treatment susceptibility or resistance of a pathogen include collecting spectra from a pathogen cultured with a treatment and from the same pathogen cultured without the treatment. The spectra are compared to determine if the pathogen is susceptible or resistant to the treatment. Systems for determining the treatment susceptibility or resistance of a pathogen are also disclosed and may include a remote computer network, which may be cloud-based.
4.WO/2020/185817METHOD OF SELECTING MICROORGANISM ISOLATES ON A HIGH-DENSITY GROWTH PLATFORM
WO 17.09.2020
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/US2020/021965 Applicant GENERAL AUTOMATION LAB TECHNOLOGIES INC. Inventor CHRISTEY, Peter
Provided is a method of using a device including a plurality of microscale experimental units. At least one cell and an indicator capable of producing an optical signal are loaded in each of the plurality of experimental units. The device with the loaded contents is incubated at predetermined conditions for a duration of time to grow a plurality of cells. At least one optical property of the contents of each of the plurality of experimental units is measured at multiple time points during the incubation to thereby obtain a time-dependent profile of the optical property for each of the plurality of experimental units. Then the time-dependent profile of the at least one optical property for the plurality of experimental units are analyzed. The result of the analysis can be used to determine whether the loaded contents include any biological entity of interest.
5.WO/2020/185907HERBICIDE TOLERANT PLANTS AND PRODUCTION AND DETECTION OF SAME
WO 17.09.2020
Int.Class A01H 1/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
1Processes for modifying genotypes
04Processes of selection
Appl.No PCT/US2020/022118 Applicant COLORADO STATE UNIVERSITY RESEARCH FOUNDATION Inventor GAINES, Todd
The present invention refers to a plant or plant part comprising a polynucleotide encoding an herbicide tolerant IAA2 polypeptide having a deleted or disrupted degron tail region, the expression of said polynucleotide confers to the plant or plant part tolerance to synthetic auxin herbicides, such as 2,4-D. The present invention relates to methods and plants and that have a deleted or disrupted degron tail region of the IAA2 protein obtained by gene editing, transformation, mutagenesis, breeding, and the like.
6.WO/2020/182106MIRNA MARKERS FOR COLORECTAL CANCER
WO 17.09.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/CN2020/078497 Applicant THE CHINESE UNIVERSITY OF HONG KONG Inventor YU, Jun
The present invention provides novel methods for diagnosing colorectal cancer in a subject or for assessing a colorectal cancer patient's likelihood of mortality from the disease by analyzing the quantity of selected miRNA species. Kits, compositions, and devices useful for these methods are also provided.
7.WO/2020/184236SELECTION MEDIUM FOR BACTERIA BELONGING TO GENUS PSEUDOMONAS AND USE THEREOF
WO 17.09.2020
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
Appl.No PCT/JP2020/008581 Applicant KABUSHIKI KAISHA YAKULT HONSHA Inventor NIIKURA Mai
The present invention specifically and quantitatively detects bacteria belonging to the genus Pseudomonas such as Pseudomonas aeruginosa by: a selection medium for bacteria belonging to the genus Pseudomonas, characterized by containing, in a basal medium, at least one third-generation cephalosporin and at least one antibiotic selected from the group consisting of first-generation cephalosporins and glycopeptide-based antibiotics; and a method for detecting bacteria belonging to the genus Pseudomonas and a method for selecting bacteria belonging to the genus Pseudomonas through use of said selection medium.
8.WO/2020/184676METHOD FOR HIGH-THROUGHPUT EVALUATION OF NMDA RECEPTOR INHIBITION ACTIVITY
WO 17.09.2020
Int.Class C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
Appl.No PCT/JP2020/010909 Applicant NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY Inventor SHIRAO, Tomoaki
The present invention addresses the problem of establishing a method for the direct, rapid and simple high-throughput evaluation of an NMDA receptor inhibition activity. An NMDA receptor inhibition activity can be evaluated with high throughput by a method comprising the following steps in this order: (A) bringing a substance of interest into contact with cultured neurons; (B) bringing the cultured neurons into contact with a glutamate solution; (C) immobilizing the cultured neurons; (D) visualizing drebrin clusters of dendritic spines of the cultured neurons; and (E) measuring the line density along the dendrites of the drebrin clusters, and determining that the substance of interest has an NMDA receptor inhibition activity when the line density is higher than the line density of the cultured neurons that are not contacted with the substance of interest.
9.WO/2020/185536A NOVEL VECTOR FOR GENE TRANSFER AND GENE COPY PROLIFERATION
WO 17.09.2020
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
Appl.No PCT/US2020/021318 Applicant CLEMSON UNIVERSITY Inventor SASKI, Christopher
The invention relates to a circular vector for plant transformation comprising: a first tethering nucleic acid and a second tethering nucleic acid; a nucleic acid encoding a polynucleotide of interest (POI); a nucleic acid comprising an origin of replication; and two or more nucleic acids encoding replicon proteins and methods for using the same. Also provided are plants produced by the methods of the invention and products produced from the plant.
10.WO/2020/185846DETECTION OF DOUBLE STRANDED NUCLEIC ACIDS IN SITU AND METHODS RELATED THERETO
WO 17.09.2020
Int.Class C12Q 1/682
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
682Signal amplification
Appl.No PCT/US2020/022010 Applicant BIO-TECHNE CORPORATION Inventor MA, Xiao-Jun
The invention provides methods for detecting target double stranded nucleic acids, including for in situ hybridization assays. The invention also provides samples of fixed and permeabilized cells with a detected target double stranded nucleic acids as well as slides containing such samples. The invention additionally provides kits for detecting target double stranded nucleic acids.