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IC:C12P19/34

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Analysis

1 / 3,254
1.WO/2025/141025NOVEL CAPPING STRATEGIES FOR MRNA 5'CAP
WO - 03.07.2025
Int.Class C07H 19/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
 Appl.No PCT/EP2024/088312 Applicant ELEVEN THERAPEUTICS LTD Inventor DELABARRE, Byron Scott
The present invention relates to synthetic cap analogs useful for the functionalization of mRNAs, which can replace canonical cap structures. Compounds disclosed herein may be functionalized with a polynucleotide using chemical synthesis approaches.
2.WO/2025/137875ISOLATED POLYPEPTIDE, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO - 03.07.2025
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/CN2023/142063 Applicant BGI SHENZHEN Inventor LIU, Shanshan
The present application provides an isolated polypeptide, a preparation method therefor, and use thereof. The polypeptide has an amino acid sequence that is at least 99% homologous with SEQ ID NO:1, and that is preferably 100% homologous therewith.
3.WO/2025/137876ISOLATED POLYPEPTIDE, PREPARATION METHOD, AND USE
WO - 03.07.2025
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/CN2023/142067 Applicant BGI SHENZHEN Inventor LI, Denghui
Provided in the present application are an isolated polypeptide, a preparation method, and a use. The polypeptide has an amino acid sequence which is at least 91% homologous or 92% homologous or 93% homologous or 94% homologous or 95% homologous or 96% homologous or 97% homologous or 98% homologous or 99% homologous to SEQ ID NO: 1.
4.WO/2025/138041T4 DNA LIGASE MUTANT AND USE THEREOF
WO - 03.07.2025
Int.Class C12N 9/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
 Appl.No PCT/CN2023/142951 Applicant BGI SHENZHEN Inventor XIE, Qingqing
Provided are a T4 DNA ligase mutant and the use thereof. The T4 DNA ligase mutant: a) has an amino acid sequence having at least 80% identity to SEQ ID NO: 1; b) comprises a substitution of an amino acid at the position corresponding to position 28 of SEQ ID NO: 1; and c) has a T4 DNA ligase activity. The T4 DNA ligase mutant has improved double-end linker connection efficiency and single-chain cyclization performance, and is compatible with different reaction systems. The T4 DNA ligase mutant can be widely used in library construction for various high-throughput sequencing, single-chain cyclization and ligation of DNA fragments in molecular cloning.
5.WO/2025/144716NUCLEOTIDES WITH ENZYMATICALLY CLEAVABLE 3'-O-GLYCOSIDE BLOCKING GROUPS FOR SEQUENCING
WO - 03.07.2025
Int.Class C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
 Appl.No PCT/US2024/061310 Applicant ILLUMINA, INC. Inventor EMOND, Stephane
Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with 3'-O-glycoside blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and methods and kits for sequencing applications.
6.WO/2025/142849MODIFIED RNA POLYMERASE
WO - 03.07.2025
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/JP2024/045489 Applicant TOYOBO CO., LTD. Inventor OCHI, Kensuke
The present invention addresses the problem of providing a novel modified RNA polymerase. The problem is solved by a modified RNA polymerase in which at least one amino acid residue at a specific position is modified.
7.WO/2025/141200MODIFIED RNA POLYMERASES
WO - 03.07.2025
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
 Appl.No PCT/EP2024/088656 Applicant SANOFI PASTEUR INC. Inventor CUI, Jianping
This application relates to modified RNA polymerases, compositions or kits comprising the same, and methods of using the same, in particular, in the preparation of ribonucleic acids (RNAs), such as messenger RNAs (mRNAs), in in vitro transcription reactions.
8.WO/2025/137872TERMINAL DEOXYRIBONUCLEOSIDE TRANSFERASE MUTANT, PREPARATION METHOD THEREFOR AND USE THEREOF
WO - 03.07.2025
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/CN2023/142043 Applicant BGI CHANGZHOU Inventor YANG, Weikang
Disclosed are a terminal deoxyribonucleoside transferase mutant, a preparation method therefor and a use thereof. A wild-type terminal deoxyribonucleoside transferase is subjected to molecular modification, to improve modified nucleic acid monomer polymerization activity and modified nucleic acid monomer catalysis efficiency, and to realize efficient single-base addition efficiency. Multiple 3'-O-blocking modified dNTPs substrates can be added to a 3'-OH end of an oligonucleotide single chain without a template, so that a novel and effective tool enzyme can be provided for the enzymatic method from de novo synthesis of nucleic acid.
9.4578954METHOD FOR ENZYMATIC POLYNUCLEOTIDE SYNTHESIS
EP - 02.07.2025
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No 25176903 Applicant DNA SCRIPT Inventor MARTIN CARL
The invention is directed to systems, apparatus and kits for automated synthesis of a plurality of polynucleotides in an array of reaction chambers using a template-free polymerase. In some embodiments, adaptive elements and processes are provided to monitor and control disruption of the synthesis process and fluid movement by enzyme aggregation.
10.4578951MULTI-FRAGMENTED POLYA POLYNUCLEOTIDE STABLY EXISTING IN HOST CELL AND USE THEREOF
EP - 02.07.2025
Int.Class C12N 15/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
68Stabilisation of the vector
 Appl.No 23856726 Applicant SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD Inventor HU YONG
A multi-segmented PolyA polynucleotide stably existing in a host cell and the use thereof. Provided first is a multi-segmented PolyA polynucleotide comprising no less than two PolyA sequence segments. Adjacent PolyA sequence segments are connected via a linker, wherein each PolyA sequence segment is composed of a plurality of continuous A, and each linker is composed of 1-24 nt nucleotide residues that are not all A. The multi-segmented PolyA polynucleotide can stably exist in a host cell, such as an Escherichia coli, during the passage process, so that the mRNA stability and protein output can be improved. Compared with a poly A sequence in a traditional unit form, the multi-segmented PolyA polynucleotide shows a greatly reduced recombination rate during fermentation in Escherichia coli and thereby is more advantageous for optimization of the amplification process, and therefore can be better applied to plasmid fermentation involved in transcription template preparation in production of mRNA vaccines or medicaments.
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