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Analysis

1.WO/2020/185627HUMAN GUT MICROBIOME-DERIVED BIOSYNTHETIC ENZYMES FOR PRODUCTION OF FATTY ACID AMIDES
WO 17.09.2020
Int.Class C12P 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
1Preparation of compounds or compositions, not provided for in groups C12P3/-C12P39/121; General processes for the preparation of compounds or compositions by using microorganisms or enzymes
04by using bacteria
Appl.No PCT/US2020/021578 Applicant MASSACHUSETTS INSTITUTE OF TECHNOLOGY Inventor VOIGT, Christopher, A.
Disclosed herein, in some embodiments, are vectors encoding biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes), engineered cells comprising the vectors, and methods of using biosynthetic enzymes from gut microbiome- derived bacterium (e.g., Clostridia enzymes) to produce fatty acid amides.
2.WO/2020/181376TSG-6 ANTIBODIES AND USES THEREFOR
WO 17.09.2020
Int.Class C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Appl.No PCT/CA2020/050321 Applicant UNIVERSITY HEALTH NETWORK Inventor BROKX, Richard
The invention provides novel anti-TSG-6 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
3.WO/2020/181846CYSTEINE-CONTAINING ANTIBODY, DRUG CONJUGATE AND USE THEREOF
WO 17.09.2020
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/CN2019/123219 Applicant XDCEXPLORER (SHANGHAI) CO., LTD. Inventor XIE, Zhenhui
Provided are a cysteine-containing antibody, a drug conjugate and a use thereof. The heavy chain constant region of the antibody is a humanized γ1 chain, and the light chain constant region thereof is a humanized κ chain, wherein amino acid residues at an A site of the heavy chain constant region and/or at a B site of the light chain constant region are replaced with cysteine, so as to provide an active site for site-directed coupling with drugs.
4.WO/2020/182976NEW LACTIC ACID BACTERIA
WO 17.09.2020
Int.Class C12R 1/46
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1Microorganisms
01Bacteria or actinomycetales
46Streptococcus
Appl.No PCT/EP2020/056766 Applicant DUPONT NUTRITION BIOSCIENCES APS Inventor JEDRZEJOWSKI, Anäis
The invention relates to a polynucleotide comprising a lacZ gene (lacZFS) encoding a β-galactosidase characterized by a particular profile regarding its efficiency of hydrolysis of lactose. The invention is also directed to a Streptococcus thermophilus strain comprising a lacZFS allele and bacterial composition thereof, and their use to obtain fermented milk not undergoing post-acidification.
5.WO/2020/183376GREENER AND ECONOMIC PROCESS FOR PREPARATION OF PREGABALIN
WO 17.09.2020
Int.Class C07C 229/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
08the nitrogen atom of the amino group being further bound to hydrogen atoms
Appl.No PCT/IB2020/052096 Applicant HIKAL LIMITED Inventor GUGALE, Shivaji
The present invention relates to an economical, enzyme catalyzed and commercially viable greener process for manufacturing Pregabalin of formula (I) in high yield with highchemical and chiral purity.
6.WO/2020/185626TROPANE ALKALOID (TA) PRODUCING NON-PLANT HOST CELLS, AND METHODS OF MAKING AND USING THE SAME
WO 17.09.2020
Int.Class A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Appl.No PCT/US2020/021577 Applicant THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Inventor SMOLKE, Christina D.
Provided herein, among other things, is an engineered non-plant cell that produces a tropane alkaloid product, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product. A method for producing a tropane alkaloid, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product that makes use of the cell is also described.
7.WO/2020/181765GEOMYCES MUTANT STRAIN AND APPLICATION THEREOF
WO 17.09.2020
Int.Class C12N 1/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
Appl.No PCT/CN2019/111010 Applicant FANG, Long Inventor WANG, Nengfei
Provided are a geomyces mutant strain and an application thereof. The mutant strain is obtained by means of a mutagenesis method, can greatly improve the yield of a red pigment, and has a preservation number: CCTCC NO: M2019086. The mutant strain can be widely applied in the production field of a natural pigment.
8.WO/2020/185485ARTIFICIAL FUSION OF DEHYDRATASE ENZYMES TO IMPROVE PRODUCTION OF FATTY ACIDS
WO 17.09.2020
Int.Class C12P 7/64
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
Appl.No PCT/US2020/021077 Applicant UNIVERSITY OF PUERTO RICO Inventor RULLÁN LIND, Carlos, Ralph
The disclosure provides fused dimer constructs that enhance fatty acid production and methods for making the dimer constructs. The fused dimer comprises Fab A and/or FabZ enzymes.
9.WO/2020/181354ENDOGENOUS PLANT EXPRESSION ENHANCER
WO 17.09.2020
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/CA2019/050319 Applicant MITSUBISHI TANABE PHARMA CORPORATION Inventor LAVOIE, Pierre-Olivier
An isolated expression enhancer active in a plant, portion of a plant or plant cell, the expression enhancer is provided. The isolated expression enhancer may be selected from the group consisting of nbEPI42 (SEQ ID NO:1); nbSNS46 (SEQ ID NO:2); nbCSY65 (SEQ ID NO:3); nbHEL40 (SEQ ID NO:4); and nbSEP44 (SEQ ID NO:5). Methods for using the isolated expression enhancer are also provided.
10.WO/2020/186224OVER-EXPRESSION OF CYTOCHROME B2 IN YEAST FOR INCREASED ETHANOL PRODUCTION
WO 17.09.2020
Int.Class C07K 14/395
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37from fungi
39from yeasts
395from Saccharomyces
Appl.No PCT/US2020/022777 Applicant DANISCO US INC Inventor MACOOL, Daniel Joseph
Described are compositions and methods relating to modified yeast that over-express cytochrome B2. The yeast produces an increased amount of alcohol compared to parental cells. Such yeast is particularly useful for large-scale ethanol production from starch substrates.