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IC:C12N15/00

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Analysis

1 / 95,260
1.2039866BROAD-SPECTRUM MESSENGER RIBONUCLEIC ACID VACCINE AGAINST CHIKUNGUNYA VIRUS DESIGNED BY OPTIMIZING FULL-LENGTH STRUCTURAL PROTEIN SEQUENCE
NL - 27.06.2025
Int.Class C07K 14/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
 Appl.No 2039866 Applicant Institute of Medical Biology, Chinese Academy of Inventor Shuaiyao Lu
The present invention belongs to the technical field of messenger ribonucleic acid {mRNA} vaccine preparation, and specifically relates to a broad—spectrum mRNA vaccine against Chilrungunya virus {CHECK-') designed by optimizing the full—length structural protein sequence. Specifically, an amino acid sequence of the protein provided by the present invention is shown in SEQ ID HD. 1. The vaccine provided by the present invention has a stronger level of cellular immune response, a higher sustained level of binding antibodies produced after a dose reaches a certain level, and a certain effect on the level of neutralizing antibodies. In a broad—spectrum, the vaccine produced IÜ neutralizing antibodies against pseudoviruses from West Afiican pedigrees, Indian lÜcean pedigrees, and East Central and SouthAfiican pedigrees, with cross—protection.Fig .l
2.20250207094SYSTEMS AND METHODS FOR UPREGULATION OF LOW-DENSITY LIPOPROTEIN RECEPTOR (LDL-R) EXPRESSION
US - 26.06.2025
Int.Class C12N 5/0783
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
 Appl.No 18987823 Applicant Kite Pharma, Inc. Inventor Maolu Li

The present disclosure describes technologies for improving a T cell manufacturing process. Specifically, upregulating low-density lipoprotein receptor (LDL-R) expression on a T cell surface. The described technologies are particularly suitable in manufacturing processes using of non-activated T cells in a transduction step.

3.20250207115ENGINEERED CRISPR-CAS13F SYSTEM AND USES THEREOF
US - 26.06.2025
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
 Appl.No 18850123 Applicant HuidaGene Therapeutics (Singapore) Pte. Ltd. Inventor Xing Wang

Provided are engineered Cas13f polypeptides, system or compositions comprising the same, and methods of using the same.

4.20250207134Use of Non-Coding Nucleic Acid for Crop Improvement and Protection Against Microbes
US - 26.06.2025
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No 19015426 Applicant University of Kentucky Research Foundation Inventor Pradeep Kachroo

A compound and method for conferring systemic acquired resistance (SAR) in plants are provided. The compound includes a nucleotide sequence derived from trans-acting small interfering RNA3a (TAS3a). The method includes exogenously applying a compound having a nucleotide sequence derived from trans-acting small interfering RNA3a (TAS3a).

5.20250207157METHODS OF PRODUCING HYDROXYTYROSOL
US - 26.06.2025
Int.Class C12P 7/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
22aromatic
 Appl.No 18791545 Applicant Conagen Inc. Inventor Rui Zhou

Provided herein is a method of producing hydroxytyrosol. The method includes: culturing a recombinant host microorganism in a medium, wherein: the host microorganism has been transformed with: a first polynucleotide sequence encoding a decarboxylase enzyme capable of decarboxylating 4 hydroxyphenylpyruvaic acid (HPP) to produce 4 hydroxyphenylacetaldehyde, and a second polynucleotide sequence encoding a hydroxylase enzyme, wherein the hydroxylase has an amino acid sequence having at least 90% identity to the amino acid sequence as set forth in SEQ ID NO: 2, and the medium comprises glucose; and collecting product hydroxytyrosol from one or both of the host microorganism and the culture medium.

6.20250207165DOUBLE STRANDED CIRCULAR DNA VECTOR, METHOD FOR PRODUCING LINEAR COVALENTLY CLOSED DNA, AND FUSION POLYPEPTIDE CONTAINING PROTELOMERASE AND ENDONUCLEASE
US - 26.06.2025
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No 19076287 Applicant KANEKA CORPORATION Inventor Mitsuki Shigeta

Provided is a double-stranded circular DNA vector, including a protelomerase gene sequence encoding a protelomerase, an endonuclease gene sequence encoding an endonuclease, a pair of protelomerase recognition sequences which are recognized by said protelomerase for cleaving said vector, at least one endonuclease recognition sequence which is recognized by said endonuclease for cleaving said vector, and a nucleic acid sequence of interest. The protelomerase gene sequence, the endonuclease gene sequence, and the endonuclease recognition sequence are placed in the same region between the pair of protelomerase recognition sequences, and the nucleic acid sequence of interest is placed in the other region between said pair of protelomerase recognition sequences in said double-stranded circular DNA vector. The protelomerase gene sequence and the endonuclease gene sequence are placed under the control of a promoter which is capable of regulating the expression.

7.WO/2025/134137REVERSIBLE LABELING OF PRIMARY ANTIBODIES
WO - 26.06.2025
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
 Appl.No PCT/IN2024/052385 Applicant INVITROGEN BIOSERVICES INDIA PRIVATE LIMITED Inventor PARAMESWARAN, Sriram
Antibody conjugates and kits for detecting antigens of interest in cell and tissue samples are described. Target-specific antibodies are reversibly labelled in a site-specific and stoichiometric manner using conjugates that include an Fc binding domain linked to a coiled- coil domain, which in turn is coupled to a labelled peptide nucleic acid (PNA) or a labelled peptide. The labelled conjugate can be released from the target-specific antibody by washing the cells or tissue in a low pH buffer, allowing for cyclic detection of target antigens in the sample. In vitro methods of detecting a target antigen in a cell or tissue sample using the antibody conjugates are also described. Methods of assembling a labelled antibody conjugate are further described.
8.WO/2025/133162RECOMBINANT PROTEIN EXPRESSION
WO - 26.06.2025
Int.Class C12N 15/63
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
 Appl.No PCT/EP2024/087965 Applicant NOVOZYMES A/S Inventor OLSEN, Carsten, Lillelund
The present invention relates to inducible promoters, and to methods of protein production, wherein recombinant cells are cultivated in a cultivation medium comprising acetate. The invention further relates to formulations and compositions obtained with the method of the invention.
9.WO/2025/129367RECOMBINANT BACMID PREPARATION SYSTEM AND BMNPV-RAAV RECOMBINANT BACMID
WO - 26.06.2025
Int.Class C12N 15/866
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
866Baculoviral vectors
 Appl.No PCT/CN2023/000125 Applicant SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES Inventor WEN, Pengjie
Provided are a recombinant bacmid preparation system and a BmNPV-recombinant adeno-associated virus (rAAV) recombinant bacmid. The recombinant bacmid preparation system comprises: a) DH10pureBac competent cells containing a loss-controllable helper plasmid and a modified baculovirus genome, and b) a loss-controllable transfer vector. The BmNPV-rAAV recombinant bacmid is a single BmNPV bacmid containing an rAAV Cap gene expression cassette, a core expression element ITR-GOI, and a Rep gene expression cassette. The present application solves the problem of residual helper plasmids and transfer vectors in a Bac-to-Bac baculovirus expression system and involves a simple technique process.
10.WO/2025/136702T-CELL RECEPTORS TARGETING EGFR AND METHODS OF USE THEREOF
WO - 26.06.2025
Int.Class C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
 Appl.No PCT/US2024/058984 Applicant BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM Inventor REUBEN, Alexandre
The present disclosure provides T-cell receptors comprising an antigen binding variable region that specifically binds an antigenic peptide derived from EGFR C797S. The present disclosure further provides activated or engineered T-cells comprising the T-cell receptors of the disclosure, and methods of making and using these T-cell receptors. Aspects of the disclosure further relate to a polypeptide comprising an antigen binding variable region comprising a CDR3 region of the disclosure.
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