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Analysis

1.WO/2020/106966SPATIAL MAPPING OF CELLS AND CELL TYPES IN COMPLEX TISSUES
WO 28.05.2020
Int.Class C12Q 1/6881
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6881for tissue or cell typing, e.g. human leukocyte antigen probes
Appl.No PCT/US2019/062628 Applicant FRED HUTCHINSON CANCER RESEARCH CENTER Inventor BIELAS, Jason
Systems and methods to tag cells in a tissue sample with spatial identifiers, so that spatial reconstruction of cell locations within a tissue can be achieved after tissue disaggregation are described. The systems and methods allow the control or directing of specific spatial identifiers spatially within or throughout a tissue to individual cells or to a small population of cells so that cell position can be determined by computational deconvolution of the spatial identifiers after tissue disaggregation. The systems and methods can be combined with single cell expression analysis to correlate cell types with cell location within a structure, such as a tumor.
2.WO/2020/105044BIOLOGICAL FLUIDIC SYSTEM
WO 28.05.2020
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/IL2019/051264 Applicant THE INTERDISCIPLINARY CENTER HERZLIYA (CC) Inventor GOME, Gilad Binyamin
The present disclosure concerns a biological fluidic system that provides a high degree of sterilization by performing the biological processing in a closed system in which the fluid is contained in chambers that are isolated from the environment in a manner that does not permit ingress of contaminants.
3.WO/2020/105381CELL DEVICE, METHOD FOR MANUFACTURING CELL DEVICE AND METHOD FOR IMPLANTING CELL DEVICE
WO 28.05.2020
Int.Class A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Appl.No PCT/JP2019/042406 Applicant HITACHI, LTD. Inventor MARUYAMA Masashi
The present invention provides: a cell device that is capable of maintaining a cell aggregate at a high number density and achieving both a high therapeutic efficacy and a low invasiveness by means of the cell aggregate; a method for manufacturing the cell device; and a method for implanting the cell device. The cell device (1) used for cell transplantation is provided with: a carrier (20) for carrying a cell aggregate (10); and a case (30) for covering the carrier (20), wherein the carrier (20) has a porous substrate (21) and a cell adhesive layer (22) that is provided on the surface of the substrate (21) and composed of cell-adhesive molecules. The method for manufacturing the cell device comprises: a step for accommodating the carrier (20) in the case (30); and a step for introducing the cell aggregate (10) into pores of the carrier (20) by applying a coercive force. The method for implanting the cell device comprises a step for implanting the cell device (1), into which the cell coagulate (10) is introduced, in a living body other than a human.
4.WO/2020/105741CELL CULTURE CONTAINER, METHOD FOR MANUFACTURING SAME, AND METHOD FOR MANUFACTURING CELL USING SAME
WO 28.05.2020
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2020/006064 Applicant KANEKA CORPORATION Inventor SAEGUSA Kazunori
The present invention relates to a cell culture container constituted from a thermoplastic resin, wherein the thermoplastic resin includes a glutarimide acrylic resin or other specific resin, the cell culture container includes a cell culture container body provided with a cell accommodating part, and the average phase difference of the bottom part of the cell culture container body is 0-15 nm. The cell culture container can be fabricated by injection molding or injection press molding of a thermoplastic resin. A predetermined cell image obtained by optical observation of cells accommodated in the cell accommodating part of the cell culture container can be analyzed using artificial intelligence (AI). The present invention thereby provides: a cell culture container whereby the risk of injury due to sample loss or damage is low, and which is suitable for microscope observation using polarized light or phase difference in applications involving observation of cell tissue, such as cell culture follow-up observation in a biochemistry-related application; a method for manufacturing the cell culture container; and a method for manufacturing a cell using the cell culture container.
5.WO/2020/099373HANDLING OF MEMBRANE-SHAPED TISSUE
WO 22.05.2020
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/EP2019/080972 Applicant UNIVERSITEIT ANTWERPEN Inventor CHAKKAR, Yassin
A tool for fixating and handling membrane-shaped tissue for research or clinical use. The tool comprises a platform comprising a base plate having at least one positioning element for positioning a spanning element on the platform, at least one round shaped spanning element adapted for being positioned on the platform using the positioning element, at least one flexible element for positioning over the round shaped spanning element for spanning the membrane shaped tissue, and at least one handling means for handling the flexible element during positioning of the flexible element over the round shaped spanning element, and for handling the combination of the round shaped spanning element and the flexible element, when the membrane is spanned over the round shaped spanning element.
6.WO/2020/100976OBJECT SURFACE PROCESSING METHOD, LAMINATE, AND LAMINATE PRODUCTION METHOD
WO 22.05.2020
Int.Class B29C 59/16
BPERFORMING OPERATIONS; TRANSPORTING
29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
59Surface shaping, e.g. embossing; Apparatus therefor
16by wave energy or particle radiation
Appl.No PCT/JP2019/044689 Applicant NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY Inventor SUZUKI, Takaaki
This object surface processing method comprises: (a) a resin layer forming step of forming a resin layer containing a photosensitive resin on a substrate; (b) a primary irradiation step of irradiating light onto the resin layer from the surface on the side of the substrate which is opposite the side on which the resin layer has been formed; (c) an object disposition step of disposing, on the light-irradiated resin layer, an object having a non-flat surface, and (d) a secondary irradiation step of further irradiating light onto the resin layer from the surface on the side of the substrate which is opposite the side on which the resin layer has been formed, wherein the primary irradiation step is carried out under conditions wherein a portion of the resin layer is not cured, and the object disposition step is carried out in such a manner that the non-flat surface of the object faces the resin layer.
7.WO/2020/099342APPARATUS, SYSTEM AND METHOD FOR BIOPROCESSING
WO 22.05.2020
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/EP2019/080904 Applicant GLOBAL LIFE SCIENCES SOLUTIONS USA LLC Inventor SMITH, Reginald, Donovan
A bioreactor vessel includes a body having upper and lower ends and a hollow interior cavity formed in the body, the interior cavity located between the upper and lower ends, the interior cavity being configured to receive biomaterials for processing. The interior cavity includes a lower boundary that is angled toward the lower end of the body such that the vessel may be tilted to allow biomaterials within the interior cavity to be extracted and concentrated and/or washed without the need for a separate bioprocessing device.
8.WO/2020/100567MEDIUM-FILLING SOLUTION, MEDIUM FILLING METHOD, CULTURE CONTAINER, AND BUBBLE-REMOVING APPARATUS FOR FILLING MEDIUM
WO 22.05.2020
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2019/042243 Applicant TOYO SEIKAN GROUP HOLDINGS, LTD. Inventor KOSEKI Osamu
According to the present invention, when cells are cultured using a culture container having fine recessed portions, bubbles collected in the fine recessed portions can be effectively removed, which can be applied to a culture container having a large culture surface. This medium filling solution is a solution in which when a medium is filled into a culture container having a culture surface in which a plurality of fine recessed portions are formed, the bubbles collected in the fine recessed portions are removed prior to the filling of the medium. This medium-filling solution is filled into the culture container having the culture surface in which the plurality of fine recessed portions are formed and is left standing for a certain period of time, a medium is then passed through the culture container, and the medium-filling solution is substituted with the medium.
9.WO/2020/101041CULTURE VESSEL AND CULTURE APPARATUS
WO 22.05.2020
Int.Class C12M 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
04with gas introduction means
Appl.No PCT/JP2019/045519 Applicant ABLE CORPORATION Inventor ISHIKAWA, Shutaro
Provided are a culture vessel and a culture apparatus, each of which has a high gas dissolution rate and a high substance dispersion rate both in a liquid culture medium, has a simple mechanism, and is easy to handle. A culture vessel 100 is equipped with a vessel main body 10, a rotational axis 22 which is attached to the bottom of the vessel main body 10, a rotating body 30 which is rotatably attached to the rotational axis 22, a porous body 40 which is attached to the rotating body 30, and a flexible suction tube 50 which can be sucked at the porous body 40 and which is fixed to the porous body at one end thereof and is fixed to the vessel main body at the other end thereof. The porous body 40 is rotatably attached to the rotating body 30, and the suction tube 50 can rotate the porous body 40 relative to the rotating body 30 with the rotation of the rotating body 30.
10.WO/2020/098958LAB-WARE AND HANDLING SYSTEM TO HANDLE LAB-WARE IN A CELL CULTURE PROCESS
WO 22.05.2020
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/EP2018/081644 Applicant AIXINNO LIMITED Inventor GILLIGAN, Patrick, Clement
Use of a set of lab-ware for a cell culture process.