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1 / 5,392
1.WO/2025/134419CELL CULTURE APPARATUS
WO - 26.06.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2024/027994 Applicant NIKKISO CO., LTD. Inventor NASU Keita
Provided is a cell culture apparatus that enables operation units having different functions to operate in a more optimized environment. The cell culture apparatus is provided with: a first space (such as the internal space of a culture medium exchange section 22) that satisfies first criteria according to air cleanliness standards (such as ISO class 5); a second space (such as the internal space of a section other than the culture medium exchange section 22) that satisfies second criteria lower than the first criteria according to the air cleanliness standards (such as ISO class 6-7); a culture medium exchange robot (42) that is arranged in the first space and can perform an operation relating to medium exchange; a transfer robot (40) that is arranged in the second space and can perform an operation of moving a well plate (52) containing a culture medium; and a control unit that sets the movable range of the culture medium exchange robot (42) to the first space when the culture medium exchange robot (42) performs the operation relating to medium exchange, and sets the movable range of the transfer robot (40) to the second space and the first space when the transfer robot (40) moves the well plate (52).
2.WO/2025/129382POROUS MEMBRANE-BASED MULTI-STAGE DRUG METABOLISM ORGAN-ON-CHIP AND APPLICATION THEREOF
WO - 26.06.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/CN2023/139418 Applicant SHANGHAI BIOCHIP CO., LTD. Inventor XU, Yichun
The present invention provides a porous membrane-based multi-stage metabolism organ-on-chip, comprising a porous membrane layer, and upper and lower chip layers, wherein a number N of non-intersected upper fluid channels are provided in the lower surface of the upper chip layer. A number N-1 of metabolic chambers are provided on the upper surface of the lower chip layer, projections of the metabolic chambers on the upper chip layer respectively overlap with two upper fluid channels adjacent thereto, and each metabolic chamber is in communication with the two upper fluid channels adjacent thereto by means of the porous membrane layer. The porous membrane layer is made of a material which is impermeable to cells but permeable to cellular metabolic secretions, wherein N is an integer greater than or equal to 2. By means of providing the porous membrane layer allowing the transfer of metabolites, the metabolites generated by the cells and test drugs in the first upper fluid channels enter the metabolic chambers on the lower chip layer, and then the metabolites in the metabolic chambers enter the next fluid channel of the upper chip layer, the cells in the next fluid channel can continue to interact with the metabolites generated in the previous stage, and the influences of multi-stage drug-cell metabolism can thus be researched.
3.3030032DEVICE FOR IN-VITRO MODELLING IN-VIVO TISSUES OF ORGANS
ES - 26.06.2025
Int.Class C12M 1/24
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
24tube or bottle type
 Appl.No 20152403 Applicant Universität Bern Inventor GUENAT, Olivier Thierry
4.WO/2025/136489AUTOMATED SYSTEM FOR CLONE SELECTION BASED ON ANTIBODY PRODUCTION AND MEASUREMENT OF CELL HEALTH PARAMETERS
WO - 26.06.2025
Int.Class G01N 35/10
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
10Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
 Appl.No PCT/US2024/051073 Applicant BECKMAN COULTER, INC. Inventor DAVIS, Matthew
Systems and method for and automated laboratory instrument for measuring protein concentration and cell health of a biological sample. The automated laboratory instrument includes a housing containing a biological sample container for receiving at least one biological sample, a pipettor to aspirate and dispense the biological sample, a titer instrument to receive the biological sample and measure protein concentration of the biological sample, a cell health instrument to receive the biological sample and measure cell health of the biological sample and processing circuitry having a memory for storing instructions. When executed by the processing circuitry, the instructions cause the processing circuitry to aspirate the biological sample from the container into the pipettor, dispense the biological sample into the titer and cell health instruments, measure protein concentration in the biological sample with the titer instrument, and measure cell health in the biological sample with the cell health instrument.
5.WO/2025/137104MULTI-CHAMBER SYSTEMS AND METHODS FOR SORTING SPERM
WO - 26.06.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/US2024/060771 Applicant COOPERSURGICAL, INC. Inventor SHARP, William Thomas
Provided herein are systems and methods for sorting sperm that in illustrative embodiments include two or more separation channels each connected to a collection chamber. In illustrative embodiments one or more of the separation channels is substantially tangent to a filter chamber, and optionally, to one or more collection chambers. In some embodiments, at least one of the separation channels is attached to a filter chamber, which is also connected to an introduction channel. Some embodiments include a plurality of separation channels and connected collection chambers. Furthermore, in some embodiments the separation channels and connected collection chambers are arranged in parallel, in serial, or a combination thereof. Some embodiments, herein include a pre-filter zone that can be a straight channel, or can be other than a straight channel, including a number of different disclosed configurations.
6.WO/2025/134839SURFACE-MODIFIED SUBSTRATE FOR CULTURING AND RECOVERING CELL CLUSTERS
WO - 26.06.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/JP2024/043464 Applicant THE UNIVERSITY OF TOKYO Inventor YAMAGUCHI Satoshi
[Problem] The present invention addresses the problem of providing a novel technique capable of efficiently preparing cell clusters, such as spheroids and organoids, in a desired shape. [Solution] It has been found that a large amount of cell clusters, such as spheroids, having a fine shape can be prepared by using a culture substrate having a specific modified surface and obtained by laminating, on a substrate, a block layer that hinders adhesion to adherent cells, and then preferably patterning and modifying cell adhesion molecules having a photodegradable linker cleaved by irradiation with light.
7.WO/2025/134045MODULAR BIOREACTOR DEVICE AND KIT THEREOF
WO - 26.06.2025
Int.Class C12M 1/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
32multiple field or continuous type
 Appl.No PCT/IB2024/063011 Applicant POLITECNICO DI MILANO Inventor MANTERO, Sara
Bioreactor device comprising: a plurality of modular elements (1, 1', 1'', 2, 2', 2'', 3, 4, 5, 6, 7, 8, 9, 10), each of said modular elements (1, 1', 1'', 2, 2', 2'', 3, 4, 5, 6, 7, 8, 9, 10) comprising at least one well (14, 14', 14'', 14''', 15, 15', 15'', 15''', 16, 16', 16'', 17, 17', 18, 18') configured to house a biological culture; and a receptacle (100, 200) configured to house the plurality of modular elements (1, 1', 1'', 2, 2', 2'', 3, 4, 5, 6, 7, 8, 9, 10), the modular elements (1, 1', 1'', 2, 2', 2'', 3, 4, 5, 6, 7, 8, 9, 10) being configured to be reversibly placed inside the receptacle (100, 200) in such a way that the at least one well (14, 14', 14'', 14''', 15, 15', 15'', 15''', 16, 16', 16'', 17, 17', 18, 18') of one modular element (1, 1', 1'', 2, 2', 2'', 3, 4, 5, 6, 7, 8, 9, 10) is insulated from the at least one well (14, 14', 14'', 14''', 15, 15', 15'', 15''', 16, 16', 16'', 17, 17', 18, 18') of another modular element (1, 1', 1'', 2, 2', 2'', 3, 4, 5, 6, 7, 8, 9, 10).
8.WO/2025/132381CELL CULTURING DEVICE
WO - 26.06.2025
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/EP2024/086828 Applicant F. HOFFMANN-LA ROCHE AG Inventor AUBERT, Julien Enzo
Disclosed herein is a cell culturing device (1) for culturing cells and/or organoids comprising a cell accommodation unit (2) comprising at least one cell culturing chamber (3) being configured for accommodating a liquid cell culturing medium (9) and a cellular structure, wherein the cell culturing chamber (3) comprises a venting opening (4) being configured for venting the cell culturing chamber; a pressure chamber (5) comprising a pressure chamber inlet (6); a channel (7) connecting the at least one cell culturing chamber (3) and the pressure chamber (5); the cell culturing device further comprising a first pressure generator (8), in particular a pump, being connected to the pressure chamber inlet and being configured for temporarily pressurizing the pressure chamber with a pressure pulse; wherein the at least one cell culturing chamber (3), the pressure chamber (5) and the channel (7) are configured such that the pressure pulse from the first pressure generator (8) propagates from the pressure chamber (5) through the channel (7) to the at least one cell culturing chamber (3) and in particular into the liquid cell culturing medium (9).
9.WO/2025/135114STEM CELL ADHESION SHEET
WO - 26.06.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/JP2024/044974 Applicant FUJITA ACADEMY Inventor HORI Hideo
The present invention addresses the problem of achieving the purpose of providing a stem cell adhesion sheet capable of stably holding a stem cell.　This stem cell adhesion sheet comprises a non-woven fabric. The non-woven fabric has a laminated structure including a first layer formed of fibers containing a biocompatible polymer as a main component, and a second layer formed of fibers containing a biocompatible polymer as a main component and having a fiber diameter greater than the fibers forming the first layer. The biocompatible polymers forming the first layer and the second layer contain the same type of polymer material.
10.20250207080METHOD FOR PERFORMING BIOPROCESSES ON CELL CULTURES
US - 26.06.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No 19078898 Applicant Daren Stephen Huttlestone Inventor Daren Stephen Huttlestone

Method for performing bioprocesses on cell cultures. The bioprocesses performed on an integrated bioprocessing system (IBS) transferring a medium in the bioprocess, in particular the cell cultures, through tubes. The IBS includes a tube connection system (tcs) connecting tubes of the IBS by welding. A first tube, first tube holder and first fluidic structure receiving and/or providing the medium are carried by a movable first carrier. The first tube is held by the first tube holder fluidically connected to the first fluidic structure. The first carrier, first tube, first tube holder and the first fluidic structure are transported to a welding location within the IBS. A welding routine at the welding location includes the tes connecting the first tube and a second tube forming a tube connection. The IBS transfers the medium from or to the first fluidic structure of the first carrier through the tube connection after welding.

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