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Analysis

1.110904056一种传染性支气管炎病毒rH120-YZS1Δ5a及其构建方法和应用
CN 24.03.2020
Int.Class C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Appl.No 201911264929.4 Applicant 江苏省家禽科学研究所 Inventor 周生
本发明提供了一种传染性支气管炎病毒rH120‑YZS1Δ5a及其构建方法和应用,属于分子生物学和基因工程技术领域,所述传染性支气管炎病毒rH120‑YZS1Δ5a保藏于中国普通微生物菌种保藏管理中心,保藏编号为CGMCC No.10499。采用本发明提供的传染性支气管炎病毒能够同时表达QX型和Mass型鸡传染性支气管炎病毒的S1蛋白,进而可用于制备预防鸡传染性支气管炎的双价疫苗。
2.110894216一种猪流行性腹泻病毒抗原表位肽、单克隆抗体及应用
CN 20.03.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 201911149815.5 Applicant 河北农业大学 Inventor 宋勤叶
本发明涉及细胞工程及免疫学技术领域,具体公开一种猪流行性腹泻病毒抗原表位肽、单克隆抗体及应用。所述抗原包含SEQ ID No.1所示的表位多肽,采用杂交瘤细胞技术制备与该抗原对应的单克隆抗体。本发明提供的单克隆抗体能够与PEDV重组S蛋白和PEDV特异性结合,该单克隆抗体可以有效鉴别PEDV变异毒株与经典毒株。
3.110894217一种牛冠状病毒嵌合抗原以及检测牛冠状病毒抗体的胶体金免疫层析试纸卡
CN 20.03.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 201911293235.3 Applicant 中国农业大学 Inventor 孟赓
本发明涉及免疫检测技术领域,公开了一种牛冠状病毒嵌合抗原以及检测牛冠状病毒抗体的胶体金免疫层析试纸卡。本发明所述嵌合抗原序列如SEQ ID NO:1所示。本发明提供了一种新型的牛冠状病毒嵌合抗原,作为牛冠状病毒抗体的检测抗原时,具备极高的特异性、重复性和准确性,能够应用在相关的免疫层析检测产品中,结果直观可肉眼判断,可快速、特异地检出血清中牛冠状病毒抗体,解决规模化奶牛场犊牛腹泻快速诊断问题,具有较高的实用价值,便于基层推广使用。
4.WO/2020/010474THE EBOLA VIRUS GLYCOPROTEIN AS A TOOL TO STIMULATE AN IMMUNE RESPONSE
WO 16.01.2020
Int.Class C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Appl.No PCT/CA2019/050975 Applicant UNIVERSITÉ LAVAL Inventor KOBINGER, Gary
Pseudotyped vesicular stomatitis viruses comprising the Ebola virus glycoprotein and antigens, as well as viral preparations and pharmaceutical composition for generating an immune response in a host or for vaccination are provided herewith. VSV-based vectors for preparing pseudotyped vesicular stomatitis viruses comprising the Ebola virus glycoprotein and antigens are also provided.
5.3172319CORONAVIRUS
PT 14.01.2020
Int.Class C12N 7/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
Appl.No 157500935 Applicant THE PIRBRIGHT INSTITUTE Inventor
6.110616198New coronavirus vaccine based on chimpanzee adenovirus type 68 and MERS-CoV full length membrane protein
CN 27.12.2019
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No 201810628239.1 Applicant TSINGHUA UNIVERSITY Inventor ZHANG LINQI
The present invention discloses a new coronavirus vaccine based on chimpanzee adenovirus type 68 and MERS-CoV full length membrane protein. The recombinant adenovirus is obtained by transfecting an adenovirus packaging cell with a recombinant plasmid and then performing cell culture; the recombinant plasmid is obtained by inserting a specific DNA molecule into a delta-E1 region of a chimpanzee adenovirus vector AdC68; the specific DNA molecule has a full-length MERS-CoV Spike protein encoding gene; and the adenovirus packaging cell has an adenovirus E1 gene. The present invention also protectsthe recombinant adenovirus expressing the full-length MERS-CoV Spike protein; and a starting strain of the recombinant adenovirus is chimpanzee adenovirus type 68 or non-replicating chimpanzee adenovirus type 68. The developed vaccine against the new coronavirus MERS-CoV has important theoretical guidance value and broad application prospects, and provides a possibility for radical cure of MiddleEast respiratory syndrome.
7.20190351049Human Antibodies to Middle East Respiratory Syndrome - Coronavirus Spike Protein
US 21.11.2019
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 16530140 Applicant Regeneron Pharmaceuticals, Inc. Inventor Christos KYRATSOUS

The present invention provides monoclonal antibodies that bind to the Middle East Respiratory Syndrome—Coronavirus (MERS-CoV) spike protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to MERS-CoV spike protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing MERS-CoV activity, thus providing a means of treating or preventing MERS infection in humans. In some embodiments, the invention provides for a combination of one or more antibodies that bind to the MERS-CoV spike protein for use in treating MERS infection. In certain embodiments, the one or more antibodies bind to distinct non-competing epitopes comprised in the receptor binding domain of the MERS-CoV spike protein.

8.20190330279SELF-ASSEMBLING INSECT FERRITIN NANOPARTICLES FOR DISPLAY OF CO-ASSEMBLED TRIMERIC ANTIGENS
US 31.10.2019
Int.Class C07K 14/11
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
11Orthomyxoviridae, e.g. influenza virus
Appl.No 16312166 Applicant The United States of America, as represented by the Secretary, Dept. of Health and Human Service Inventor Peter Kwong

Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

9.110376385Preparation method and application of genetic engineering expressed QX type chicken infectious bronchitis virus S1 protein antigen
CN 25.10.2019
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 201910674813.1 Applicant YANGZHOU UNIVERSITY Inventor ZHANG XIAORONG
The invention belongs to the biotechnology field, and relates to a preparation method and an application of a genetic engineering expressed QX type chicken infectious bronchitis virus S1 protein antigen. The invention discloses the application of the S1-E protein with the sequence shown as SEQ ID NO.9 serving as an antigen for detecting an IBV antibody. The invention discloses a detection kit usedfor detecting the IBV antibody, and further discloses the preparation method of the genetic engineering expressed QX type chicken infectious bronchitis virus S1 protein antigen. The genetic engineering recombined QX type IBV S1 protein antigen S1-E provided by the invention can be specifically bound to QX type IBV positive serum, has weak cross-reaction with non-QX type IBV positive serum, and can be used for monitoring and assessment of a QX type IB vaccine immune antibody.
10.2019100990RECOMBINANT SHUTTLE PLASMID CONTAINING PORCINE EPIDEMIC DIARRHEA VIRUS S GENE, RECOMBINANT ADENOVIRUS, AND APPLICATION THEREOF
AU 19.09.2019
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 2019100990 Applicant Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Inventor
The present invention provides a recombinant shuttle plasmid containing porcine epidemic diarrhea virus (PEDV) S gene, a recombinant adenovirus, and an application thereof, and relates to the technical field of genetic engineering vaccine. The recombinant adenovirus constructed by the present invention has a high titer, reaching up to 1x1011 PFU/mL, which can provide important support for clinically effective prevention and control of PEDV.