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1.WO/2020/236526TRANSLOCATION CONTROL ELEMENTS, REPORTER CODES, AND FURTHER MEANS FOR TRANSLOCATION CONTROL FOR USE IN NANOPORE SEQUENCING
WO 26.11.2020
Int.Class C07D 473/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
18one oxygen and one nitrogen atom, e.g. guanine
Appl.No PCT/US2020/032950 Applicant STRATOS GENOMICS, INC. Inventor O'CONNELL, Dylan
Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocation control element, and a second reporter code, wherein the ends of the reporter construct are attached to phosphoramidate-nucleoside. Related methods and products are also provided.
2.WO/2020/237115METHODS OF FULL-LENGTH RNA PROFILING
WO 26.11.2020
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2020/034127 Applicant THE ROCKEFELLER UNIVERSITY Inventor LIU, Shixin
The invention relates to the characterization of nucleic acid, particularly RNA, and to full-length transcript profiling of RNA. The invention relates to methods, aspects and kits for determining a transcriptome of an organism, including simultaneously capturing sequences of both the 5' and 3' termini of transcripts so as to characterize all transcripts or RNAs and to provide transcription start and termination sites of a transcriptome with nucleotide resolution.
3.WO/2020/237010METHOD FOR AMPLIFYING AND DETECTING RIBONUCLEIC ACID (RNA) FRAGMENTS
WO 26.11.2020
Int.Class A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
Appl.No PCT/US2020/033929 Applicant ACADEMIA SINICA Inventor CHIU, Kuo-Ping
The present invention relates to a method for amplifying and detecting ribonucleic acid (RNA) fragments. In particular, the method of the present invention comprises conversion of RNA fragments to cDNA and DNA amplification. The present invention also provides a kit for performing the method as described herein.
4.WO/2020/234208PROCESS FOR THE PREPARATION OF GALNAC PHOSPHORAMIDITE EPIMERS
WO 26.11.2020
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Appl.No PCT/EP2020/063749 Applicant F. HOFFMANN-LA ROCHE AG Inventor BREITLER, Simon Adolf
The invention comprises a process for the preparation of a GalNAc phosphoramidite epimer of the formula (I), wherein R1 is a hydroxy protecting group, n is an integer from 0 to 10 and m is an integer from 0 to 20, corresponding enantiomers and/ or optical isomers thereof and the use of the process for the preparation of GalNAc-cluster oligonucleotide conjugates.
5.WO/2020/234498GENE THERAPY WITH THE GENES HOKD AND LDRB FOR CANCER TREATMENTS
WO 26.11.2020
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/ES2020/070315 Applicant UNIVERSIDAD DE GRANADA Inventor BOULAIZ TASSI, Houria
The invention relates to the isolated RNA or DNA polynucleotides hokD and ldrB for use in medicine, particularly in gene therapy for cancer treatment. Also described are compositions comprising such polynucleotides or related genetic structures, and a method for treating proliferative disorders, preferably cancer.
6.WO/2020/235658MULTI-FLUOROUS BLOCKMER USED IN OLIGONUCLEOTIDE SYNTHESIS AND OLIGONUCLEOTIDE SYNTHESIS METHOD USING SAME
WO 26.11.2020
Int.Class C07H 19/073
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
Appl.No PCT/JP2020/020203 Applicant SHIKOKU NUCLEIC ACID CHEMISTRY CO. LTD. Inventor KATAOKA, Masanori
Provided are a multi-fluorous blockmer capable of reducing the purification burden using a readily available fluorous tag, and an oligonucleotide synthesis method using the same. A multi-fluorous blockmer represented by the formula is synthesized: B is a natural or modified nucleobase; R1 is a protecting group that can be deprotected under acidic or neutral conditions; R3 is a phosphate protecting group; Pro is unprotected, protected, or an F-protector, O(CH2)n(CF2)mCJ3 when the portion of the nucleoside base to be protected is O and NH(C=O)(CH2)n(CF2)mCF3 when the portion of the nucleoside base to be protected is N, n is 1 or 2, and m is an integer of 1-20; X is O or S; I is an integer of from 0 to 58; R7 is (C=O)(CH2)2(C=O)(CH2)n(CF2)mCF3 or a silyl protecting group, n is 1 or 2, and m is an integer of 1-20.
7.WO/2020/236618SYNTHESIS OF OLIGOMERIC COMPOUNDS COMPRISING PHOSPHOROTHIOATE DIESTER AND PHOSPHATE DIESTER LINKAGES
WO 26.11.2020
Int.Class C07F 9/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
Appl.No PCT/US2020/033196 Applicant IONIS PHARMACEUTICALS, INC. Inventor MCPHERSON, Andrew K.
The present disclosure provides methods for synthesizing oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage. In certain embodiments, the present disclosure provides oxidation reagents that produce low amounts of unwanted phosphate diester impurities in oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage.
8.WO/2020/232165BISPECIFIC ANTI-CD3 X CD20 ANTIBODIES AND USES THEREOF
WO 19.11.2020
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Appl.No PCT/US2020/032738 Applicant QLB BIOTHERAPEUTICS Inventor TU, Chao
The disclosure relates to bispecific anti-CD3 x CD20 antibodies comprising (i) a single-chain CD3 binding moiety, (ii) a single-chain CD20 binding moiety, and preferably (iii) an Fc region. Aspects of the disclosure further relate to compositions comprising these bispecific antibodies, vectors comprising one or more polynucleotides encoding these bispecific antibodies, as well as uses of these bispecific antibodies for treating a subject suffering from a B cell-related cancer, in particular, a subject who has developed resistance to anti-CD20, e.g., rituximab, therapy..
9.20200361984CLICK BASED LIGATION
US 19.11.2020
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Appl.No 16651450 Applicant BASECLICK GMBH Inventor Thomas FRISCHMUTH

The present invention relates to new methods and reagents for coupling molecules by a so-called click reaction in the presence of a suitable catalyst and a metal cation. Further, the invention relates to an activator composition for such click ligation reaction, a click ligation reagent kit, a device for performing such click ligation reaction, and the use of such method, composition, reagent kit and device to improve the efficiency of coupling of molecules via a click reaction, especially in the context of next generation nucleic acid sequencing methods.

10.20200362343METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
US 19.11.2020
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No 16853670 Applicant Larry J. Smith Inventor Larry J. Smith

Compositions and methods for down modulating expression of target nucleic acids using a single strand oligoribonucleotide siRNA compound are disclosed.