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Analysis

1.WO/2020/104492PYRIDINIUM SALTS AS ACTIVATORS IN THE SYNTHESIS OF STEREODEFINED OLIGONUCLEOTIDES
WO 28.05.2020
Int.Class C07H 1/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
02Phosphorylation
Appl.No PCT/EP2019/081864 Applicant ROCHE INNOVATION CENTER COPENHAGEN A/S Inventor HANSEN, Dennis Jul
The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling activator.
2.10662484Two universal duplex primer sets and a combined real-time PCR and high resolution melt analysis assay for the amplification of gram-positive and gram-negative bacteria
US 26.05.2020
Int.Class C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
Appl.No 15468454 Applicant Bench in a Box, LLC Inventor Joshua A. Smith

Provided herein are biological assay mixtures for use in a real-time PCR and High Resolution Melt Analysis (HRMA) comprising: a universal Gram-positive forward and reverse primer pair; a universal Gram-negative forward and reverse primer pair; at least two biological probes, each one comprising a fluorophore, able to detect an amplicon prepared by the universal primer pairs; and an oligonucleotide intercalating dye for the HRMA. Methods for detecting a plurality of bacterial strains in the assay, comprise: contacting a biological sample with the biological assay mixture; preparing a plurality of amplicons for both Gram-positive and Gram-negative bacteria using one of the universal primer pairs; and detecting the amplicons using a plurality of biological probes comprising a fluorophore of one or more color emitters able to hybridize to known bacterial strains, wherein if no bacterial strain is identified, then determining whether Gram-positive and Gram-negative strains exist by using HRMA.

3.WO/2020/102142MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-10B ACTIVITY
WO 22.05.2020
Int.Class A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Appl.No PCT/US2019/060841 Applicant REGULUS THERAPEUTICS INC. Inventor ALLERSON, Charles R.
Described herein are compositions and methods for the inhibition of miR-10b activity. The compositions may be administered to subjects with cancer, such as glioma.
4.WO/2020/102558MODULATORS OF FOXP3 EXPRESSION
WO 22.05.2020
Int.Class A61K 31/712
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
Appl.No PCT/US2019/061508 Applicant IONIS PHARMACEUTICALS, INC. Inventor REVENKO, Alexey
The present embodiments provide methods, compounds, and compositions useful for inhibiting FOXP3 expression, which may be useful for treating, preventing, or ameliorating cancer. Certain embodiments provided herein are directed to potent and tolerable compounds and compositions useful for inhibiting FOXP3 expression, which can be useful for treating, preventing, ameliorating, or slowing progression of cancer. In certain embodiments, the cancer is associated with an immunosuppressive microenvironment or stroma.
5.WO/2020/101909IDENTIFICATION OF JUND TARGET GENES FOR INHIBITION OF PROSTATE CANCER CELL GROWTH
WO 22.05.2020
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No PCT/US2019/059216 Applicant CENTER FOR CANCER RESEARCH & THERAPEUTIC DEVELOPMENT, CLARK ATLANTA UNIVERSITY Inventor THOMPSON-ELLIS, Bethtrice
This disclosure generally relates to the development of therapeutic and chemo-preventative strategies to prostate cancer initiation and carcinogenesis. Specifically, the disclosure relates to the role the JunD transcription factor plays in the deregulation of cell proliferation. The disclosure relates to a novel method of identifying JunD target genes and inhibiting the expression and/or function of the JunD target genes to interfere with the regulation of cancer cell proliferation and early stages of carcinogenesis.
6.WO/2020/102570RNA PRESERVATION SOLUTION AND METHODS OF MANUFACTURE AND USE
WO 22.05.2020
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/US2019/061525 Applicant SPECTRUM SOLUTIONS L.L.C. Inventor GAETA, Federico
Disclosed is nucleic acid preserving compositions and methods of manufacturing and using the same. Compositions include a carrier, a chaotropic agent, a buffering agent, a chelating agent, a surfactant, an alcohol, and a reducing agent. Compositions as aqueous solutions can include water as a carrier. Preferred embodiments include RNAse-free water, lithium chloride, sodium citrate, EDTA, CTAB or SLS, SDA 3C, and TCEP, with HCl optionally added to adjust pH. Some embodiments include a colored dye as a visual indicator. Methods of manufacturing include combining the components into a mixture, such as an aqueous solution. Methods of use include providing a biological sample that includes nucleic acid, preferably RNA, and contacting the biological sample with the composition. Kits include a biological sample collection apparatus and the composition. The composition is optionally disposed in a portion of the collection apparatus.
7.WO/2020/098474BUFFER SOLUTION FOR NUCLEIC ACID AMPLIFICATION COLORIMETRIC REACTION AND APPLICATION THEREOF
WO 22.05.2020
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/CN2019/113872 Applicant QINGDAO NAVID BIOTECHNOLOGY CO., LTD. Inventor SHI, Chao
Disclosed in the present invention are a buffer solution for a nucleic acid amplification colorimetric reaction and application thereof. The buffer solution for a nucleic acid amplification colorimetric reaction in the present invention contains components having the following concentrations: a weak acidic substance: 0.5-10 mM and a divalent cationic salt: 0.5-10 mM. The buffer solution of the present invention is applied to preparation of a nucleic acid amplification colorimetric reaction system and/or nucleic acid amplification fluorescence detection. The nucleic acid amplification colorimetric reaction system of the present invention comprises one or more pairs of oligonucleotide primers for target nucleic acid amplification, one or more types of DNA polymerases, the buffer solution for the colorimetric reaction, and dNTPs.
8.WO/2020/102287COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND IDENTIFICATION OF COVALENT APTAMERS
WO 22.05.2020
Int.Class C12Q 1/6811
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6811Selection methods for production or design of target specific oligonucleotides or binding molecules
Appl.No PCT/US2019/061096 Applicant UNIVERSITY OF HAWAII Inventor MACPHERSON, Iain, Seido
Compositions and methods for preparing and identifying aptamers and aptamer-protein conjugates are provided. The use of a nucleotide analog functionalized with an amine- reactive cross-linker facilitates covalent cross-linking of the aptamer to a protein, in particular site-specific cross-linking to the Fc domain of an antibody.
9.20200157130METHODS AND COMPOSITIONS FOR PREPARING NUCLEIC ACIDS THAT PRESERVE SPATIAL-PROXIMAL CONTIGUITY INFORMATION
US 21.05.2020
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Appl.No 16689002 Applicant ARIMA GENOMICS, INC. Inventor Anthony SCHMITT

Provided herein are methods and compositions for preparing nucleic acids in samples that preserve spatial-proximal contiguity information. Samples include, but are not limited to, formalin-fixed paraffin-embedded (FFPE) samples, deeply formalin-fixed samples and samples that comprise protein:cfDNA complexes.

10.20200157606NUCLEOTIDE ANALOGS
US 21.05.2020
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No 16752865 Applicant ABBOTT MOLECULAR INC. Inventor Dae Hyun Kim

Provided herein is technology relating to the manipulation and detection of nucleic acids, including but not limited to compositions, methods, and kits related to nucleotides comprising a chemically reactive linking moiety.