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Analysis

1.WO/2020/184677ANTI-HEPATITIS B VIRUS AGENT
WO 17.09.2020
Int.Class A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Appl.No PCT/JP2020/010910 Applicant DAIKIN INDUSTRIES, LTD. Inventor HAMADA, Tomohito
The present invention addresses the problem of providing an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-associated diseases, containing a nucleic acid analog as an active ingredient. The problem can be solved by an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-associated diseases, containing, as an active ingredient, a compound represented by formula (1) (in the formula, R represents a halogen atom, an amino group, a methoxy group, or a cyano group) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
2.WO/2020/185907HERBICIDE TOLERANT PLANTS AND PRODUCTION AND DETECTION OF SAME
WO 17.09.2020
Int.Class A01H 1/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
1Processes for modifying genotypes
04Processes of selection
Appl.No PCT/US2020/022118 Applicant COLORADO STATE UNIVERSITY RESEARCH FOUNDATION Inventor GAINES, Todd
The present invention refers to a plant or plant part comprising a polynucleotide encoding an herbicide tolerant IAA2 polypeptide having a deleted or disrupted degron tail region, the expression of said polynucleotide confers to the plant or plant part tolerance to synthetic auxin herbicides, such as 2,4-D. The present invention relates to methods and plants and that have a deleted or disrupted degron tail region of the IAA2 protein obtained by gene editing, transformation, mutagenesis, breeding, and the like.
3.WO/2020/181825NUCLEIC ACID EXTRACTION APPARATUS
WO 17.09.2020
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/CN2019/119366 Applicant CHEN, Hui Inventor CHEN, Hui
Disclosed is a nucleic acid extraction apparatus. The nucleic acid extraction apparatus comprises a workbench having a table top, and further comprises a sliding seat, a sample rack, a reagent strip rack, a pipetting table, a piston assembly and a suction assembly. The nucleic acid extraction apparatus comprises the sliding seat and the pipetting table, the sample rack and the reagent strip rack are arranged on the sliding seat, the piston assembly and the suction assembly are respectively arranged on the pipetting table, the sample rack is provided with sample holes, the reagent strip rack is provided with accommodation slots, the number of accommodation slots corresponds to that of the sample holes on a one-to-one basis, and when reagent strips are respectively accommodated in the accommodation slots, a first suction head hole, second suction head holes and various reagent holes in each reagent strip respectively correspond to the corresponding sample holes, such that the loading of a suction head assembly and suction heads and operations such as suction, injection and mixing of a sample and various reagents can be realized by means of a vertical movement, relative to the sliding seat, of the pipetting table and a horizontal movement, relative to the pipetting table, of the sliding seat, thereby realizing the automated operation of nucleic acid extraction.
4.WO/2020/186124MODIFIED MICRORNAS AND THEIR USE IN THE TREATMENT OF CANCER
WO 17.09.2020
Int.Class A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Appl.No PCT/US2020/022519 Applicant THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK Inventor JU, Jingfang
The present disclosure provides modified microRNA nucleic acid compositions that have one or more cytosine and/or uracil bases replaced with gemcitabine or a 5-halouracil, respectively. More specifically, the present disclosure reveals that the replacement of cytosine nucleotides within a microRNA nucleotide sequence with a gemcitabine molecule increases the ability of the microRNA to inhibit cancer progression and tumorigenesis. In addition, the present disclosure reveals that the replacement of cytosine nucleotides within a microRNA nucleotide sequence with a gemcitabine molecule and replacement of uracil bases with 5-halouracil increases the ability of the microRNA to inhibit cancer development. As such, the present disclosure provides various modified nucleic acid (e.g., microRNA) compositions having gemcitabine molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.
5.WO/2020/183442PHENYLPROPANOID SACCHARIDE ESTERS, METHODS AND USES THEREOF
WO 17.09.2020
Int.Class C07H 13/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02by carboxylic acids
04having the esterifying carboxyl radicals attached to acyclic carbon atoms
Appl.No PCT/IB2020/052378 Applicant UNIVERSIDADE NOVA DE LISBOA Inventor MARKOVA-PETROVA, Krasimira Todorova
The present disclosure relates to phenylpropanoid saccharide esters, methods for the synthesis of libraries of phenylpropanoid saccharide esters with different degree and place of substitution in the sugar core, and their use as antimicrobial agents, cytotoxic agents and/or antitumoral agents. The present disclosure relates to a compound for formula I wherein R1, R2, R3 and R4 are independently selected from each other; R1 is selected from H or COCH3, R2, R3 and R4 is selected from H, OCH3, OH, for use in a method for the treatment of a microbial infection, or for use in a method for the treatment of a fungal infection or for use in a method for the treatment of cancer.
6.WO/2020/185562NOVEL ANTIMICROBIAL LANTIBIOTIC PEPTIDE AND USES THEREOF
WO 17.09.2020
Int.Class C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Appl.No PCT/US2020/021396 Applicant FRAUNHOFER USA, INC. Inventor KARCZEWSKI, Jerzy
A novel lantibiotic peptide and a composition comprising the peptide in an antimicrobial effective amount are provided. A method for preparing the composition from a medium into which host cells produce the peptide is also provided. A method of inhibiting growth of microbial cells, killing microbial cells or treating a subject infected by microbial cells, comprising administering to the microbial cells or the subject an effective amount of the peptide or the composition is further provided. Where the microbial cells are on a surface, the method may further comprise administering the peptide or the composition to the surface.
7.WO/2020/185681COMPOSITIONS AND METHODS RELATED TO GOLD-MEDIATED NUCLEIC ACID HYBRIDIZATION
WO 17.09.2020
Int.Class C07H 23/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
23Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Appl.No PCT/US2020/021716 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor NELSON, Hosea, M.
The present disclosure provides a gold-containing compound including an aurous gold atom and a nucleic acid strand that forms a toehold-stem-loop structure, in which the aurous gold atom is complexed with a mismatched pair of residues in the stem portion of the nucleic acid strand. The disclosure also provides a gold-containing double-stranded nucleic acid including an aurous gold coordinated between a first nucleobase and a mismatching second nucleobase. Related methods of increasing stability of a nucleic acid duplex, regulating an aurous-gold-catalyzed reaction, detecting an oligonucleotide, and detecting aurous gold in a substance are additionally provided.
8.WO/2020/185781MICRORNA REGULATORY NETWORK AS BIOMARKERS OF SEIZURE IN PATIENTS WITH SPONTANEOUS INTRACEREBRAL HEMORRHAGE
WO 17.09.2020
Int.Class A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Appl.No PCT/US2020/021896 Applicant OCHSNER HEALTH SYSTEM Inventor IWUCHUKWU, Ifeanyi
A method of predicting seizure in a subject that has had an intracerebral hemorrhage, comprising: measuring at least one of miRNA listed in Tables 1A, 1B, 1C and 6-8 in a sample obtained from a subject, wherein the at least one of miRNA comprises at least one of hsa-miR-4325, hsa-miR-181a-5p, hsa-miR-1180-3p, and miR-4317 wherein down regulation of hsa-miR-4325 or hsa-miR-4317 relative to a control indicates the subject will exhibit seizures and wherein upregulation of hsa-miR-181a-5p and hsa-miR-1180-3p, relative to a control indicates the subject will exhibit seizures.
9.WO/2020/184799OLIGONUCLEOTIDE HAVING ANTI-INFLAMMATORY ACTIVITY
WO 17.09.2020
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/KR2019/013184 Applicant PARK, Donghwi Inventor PARK, Donghwi
The present invention pertains to: an oligonucleotide having an anti-inflammatory activity; and a pharmaceutical composition containing same for preventing or treating inflammatory diseases.
10.WO/2020/183238REVERSIBLE COATING OF CHITOSAN-NUCLEIC ACID NANOPARTICLES AND METHODS OF THEIR USE
WO 17.09.2020
Int.Class A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Appl.No PCT/IB2020/000175 Applicant ENGENE, INC. Inventor PANICKER, Rajesh Krishnan Gopalakrishna
Chitosan-nucleic acid polyplex compositions containing a reversibly bound polymer coat comprising linear block copolymers with a polyanionic anchor region and at least one polyethylene glycol tail region are described herein. In some cases, the compositions exhibit improved stability and/or mucosal diffusion as compared to uncoated particles. In some cases, the reversibly bound polymer coat does not interfere with, or enhances, transfection of target cells or tissues as compared to uncoated particles.