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1.WO/2020/181687PREPARATION METHOD FOR AND INTERMEDIATE OF DRUG-LINKER FOR ANTIBODY DRUG CONJUGATE MC-MMAF
WO 17.09.2020
Int.Class C07K 5/062
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
062the side chain of the first amino acid being acyclic, e.g. Gly, Ala
Appl.No PCT/CN2019/092950 Applicant LEVENA BIOPHARMA CO., LTD. Inventor XU, Zhe
A preparation method for and an intermediate of a drug-linker for an antibody drug conjugate MC-MMAF. The reaction activity of the N-terminus is improved, so that the occurrence of a racemic reaction is effectively controlled. The toxin MMAF is not directly used and a fragment peptide having low toxicity is used, so that an operation difficulty in mass production is reduced. No reverse-phase preparation is required so that the operations are simple.
2.WO/2020/181837METHOD FOR RESCUING INFLUENZA VIRUS AND COMPOSITION THEREFOR
WO 17.09.2020
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No PCT/CN2019/121905 Applicant ZHEJIANG SENWEI BIOPHARMACEUTICAL DEVELOPMENT CO., LTD. Inventor DAI, Dongsheng
Provided are a new method for rescuing an influenza virus and a composition therefor. The method comprises providing a host cell stably integrated with and expressing influenza virus PA, PB1, PB2 and NP genes, and introducing an influenza virus rescue system in which a stop codon is introduced into the PA, PB1, PB2 and NP genes respectively into the host cell to achieve virus rescue. The produced virus particles can be used as a live attenuated influenza vaccine, which is characterized in that, since the genes encoding the related proteins are mutated, it has no replication and proliferation ability in human and normal animal cells, and replication and proliferation can be achieved only in the host cells constructed above and it can fully stimulate the body immunity and effectively protect the body while ensuring the safety.
3.WO/2020/182077USE OF GLI2 INHIBITOR AND METHOD FOR SCREENING COMPOUND INHIBITING GLI2
WO 17.09.2020
Int.Class C07C 405/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
405Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
Appl.No PCT/CN2020/078224 Applicant INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES Inventor WANG, Yu
A prostaglandin as represented by formula I and an analog thereof used as medicines, and a pharmaceutical composition containing the compounds, particularly used as an inhibitor of zinc finger domain-containing protein GLI2 (i.e., glioma-associated oncogene-2), and used for treatment, prevention, or alleviation of tumors (particularly tumor resistance) in subjects, or neurodegenerative diseases or developmental syndromes and malformations caused by dysregulation of signaling pathways involving GLI2. Also provided is a method for screening a compound inhibiting GLI2.
4.WO/2020/182197LIQUID COMPOSITION COMPRISING ANTIBODY OF HUMAN INTERLEUKIN-4 RECEPTOR ALPHA
WO 17.09.2020
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/CN2020/079120 Applicant SUZHOU CONNECT BIOPHARMACEUTICALS, LTD. Inventor ZHENG, Wei
The present invention provides a liquid composition comprising an antibody of human interleukin-4 receptor alpha. The liquid composition comprises the antibody at a concentration of 50-200 mg/ml; and a buffer, a protectant, and a surfactant as adjuvants. The liquid composition has a pH of 5.4-6.4.
5.WO/2020/182417COSMETIC PREPARATION CONTAINING A STARCH DERIVATIVE
WO 17.09.2020
Int.Class A61K 8/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
06Emulsions
Appl.No PCT/EP2020/054023 Applicant BEIERSDORF AG Inventor PESCHKE, Lisa
The invention relates to a cosmetic emulsion containing sodium carboxymethyl starch and at least one emulsifier selected from the group of polyglyceryl-10 stearates and fatty acids having 14 to 22 carbon atoms, or salts thereof.
6.WO/2020/182927POTASSIUM-BINDING AGENTS FOR USE IN HEMODIALYSIS PATIENTS
WO 17.09.2020
Int.Class A61K 33/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
Appl.No PCT/EP2020/056595 Applicant ASTRAZENECA AB Inventor JONASSON, Jenny
The present invention relates to the use of potassium-binding agents that are formulated to remove toxins, e.g., potassium ions, from the gastrointestinal tract at an elevated rate, without causing undesirable side effects, in hemodialysis patients. The compositions exhibit desired characteristics for the long term administration to treat or prevent the relapse or occurrence of certain conditions, for example hyperkalemia.
7.WO/2020/182947MACROCYCLES WITH ANTIOXIDANT AND NEUROPROTECTIVE ACTIVITIES
WO 17.09.2020
Int.Class A61K 31/407
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
Appl.No PCT/EP2020/056665 Applicant INSTITUTO BIOMAR, S.A Inventor FERNÁNDEZ MEDARDE, Antonio
Compounds of general formula wherein the wavy bond ~ is either a double bond or the epoxide, or pharmaceutically acceptable salts, solvates, tautomers, or stereoisomers thereof, for use in the treatment of diseases associated with oxidative stress.
8.WO/2020/183047DECELLULARISED SCLEROCORNEAL LIMBUS
WO 17.09.2020
Int.Class A61F 2/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
14Eye parts, e.g. lenses, corneal implants; Artificial eyes
Appl.No PCT/ES2020/070168 Applicant UNIVERSIDAD DE GRANADA Inventor CARO MAGDALENO, Manuel
The invention describes a biomimetic limbus obtained from decellularised sclerocorneal limbus, artifical fabric and composition comprising said limbus, in addition to its use in the preparation of a drug for treating limbal insufficiency or as a cell factor and/or drug release system.
9.WO/2020/183147IMMUNOTHERAPY COMBINED WITH AN ANTI-CD38 ANTIBODY
WO 17.09.2020
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/GB2020/050567 Applicant AUTOLUS LIMITED Inventor PEDDAREDDIGARI, Vijay
The present invention relates to the use of an anti-CD38 antibody in a subject undergoing immunotherapy wherein the anti-CD38 antibody is administered before and/or after immunotherapy.
10.WO/2020/183227TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A COMPLICATION RISK FACTOR
WO 17.09.2020
Int.Class A61K 31/5383
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
Appl.No PCT/IB2019/052012 Applicant SHIONOGI & CO., LTD. Inventor UEHARA, Takeki
A method for treating an influenza virus infection is described. The disclosed method generally involves administering an effective amount of a compound, for example baloxavir marboxil, to a subject having an influenza virus infection and at least one complication risk factor. Generally, the amount is effective such that a reduction in a time to improvement of at least one symptom of an influenza virus infection is statistically significant as compared to that of a non-treated subject.