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Analysis

1.WO/2020/232502PREDICTION AND INTERVENTION OF OBSTRUCTIVE SLEEP APNOEA
WO 26.11.2020
Int.Class A61B 5/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
Appl.No PCT/AU2020/050494 Applicant COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION Inventor BAFKAR, Omid
Described herein are systems and methods for the simulation of the upper airway of a subject. One embodiments provides a method (100) including the initial step (101) of receiving one or more tomographic images of the subject. At step (102) a three dimensional geometric model of the upper airway is generated from the one or more tomographic images. The geometric model includes a network of interconnected deformable mesh elements collectively defining a fluid domain (310) and a solid domain (320). The solid domain (320) defining a single unitary model of the entire upper airway region segmented into a plurality of predefined geometric regions, each being defined by one or more common anatomical parameters. At step (103), a computer simulation is performed on the geometric model to simulate behaviour of the upper airway when the subject is positioned in a predefined position. The computer simulation includes (103a) performing a Computational Fluid Dynamics (CFD) analysis on the fluid domain and then (103b) performing a Fluid-Structure Interaction (FSI) analysis between the fluid and solid domains under the influence of an applied gravity effect. Finally, at step (104), subject-specific parameters are output which are indicative of the behaviour of the upper airway.
2.WO/2020/232509METHODS FOR ESTIMATING KEY PHENOTYPIC TRAITS FOR OBSTRUCTIVE SLEEP APNEA AND SIMPLIFIED CLINICAL TOOLS TO DIRECT TARGETED THERAPY
WO 26.11.2020
Int.Class A61B 5/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
Appl.No PCT/AU2020/050506 Applicant FLINDERS UNIVERSITY Inventor ECKERT, Danny J.
A method of predicting the likelihood of responding to one or more obstructive sleep apnea (OSA) treatments for obstructive sleep apnea (OSA) of a candidate subject, the method including the steps of: (a) measuring a first series of polysomnography and anthropometric parameters for at least a collection of OSA sufferers; (b) correlating the parameters with at least one of the corresponding upper-airway collapsibility (Pcrit), arousal threshold, loop gain and pharyngeal muscle responsiveness measurement of each subject; (c) determining a corresponding description structure describing the correlation of step (d); and (d) utilising the corresponding description structure, in conjunction with a series of polysomnography and anthropometric parameters measured for the candidate subject to predict the likelihood of responding to one or more obstructive sleep apnea (OSA) treatments to thereby provide a clinical decision diagnostic tool for obstructive sleep apnea.
3.WO/2020/234338DISPOSABLE WEARABLE SENSOR FOR CONTINUOUS MONITORING OF BREATH BIOCHEMISTRY
WO 26.11.2020
Int.Class G01N 27/27
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
27Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
Appl.No PCT/EP2020/064041 Applicant ALBERT-LUDWIG-UNIVERSITÄT FREIBURG Inventor DINCER, Can
The invention relates to an electrochemical method and an electrochemical sensor for breath analysis of single or multiple analytes using a porous, preferably flexible and disposable supporting material, wherein a salt is incorporated, and which can be wetted in contact with the exhaled breath condensate, acting simultaneously as sampling method, as an electrolyte and as a support for the electrode structures. In some embodiments the salt may be hygroscopic, such that the porous substrate stays wet. To ensure that the obtained signal originates from the analyte, the electrochemical sensor preferably exhibits a differential electrode design, comprising a sensing (analyte-sensitive) and a blank (analyte-insensitive) electrode in order to isolate and remove the background signals.
4.WO/2020/234878SYSTEMS AND METHODS FOR ALIGNMENT OF SENSORS ACROSS A CHEST OF A TARGET PATIENT
WO 26.11.2020
Int.Class A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
Appl.No PCT/IL2020/050551 Applicant SENSIBLE MEDICAL INNOVATIONS LTD. Inventor SAROKA, Amir
There is provided an apparatus for positioning a front sensor and/or a back sensor across a thorax of a target individual, the apparatus comprising: a back positioning element comprising: a collar sized and shaped for fitting to a shoulder line and base of a back of a neck of the target individual, and an elongated element having a first end region connected to the collar, and a second end region with a location marker set to correspond to a target anatomical feature of the spine of the target individual, wherein when in use, the elongated element is positioned parallel to and over a long axis of a spine on the back of the target individual, and at least one front sensor and at least one back sensor are positioned on the thorax of the patient relative to the back positioning element for transmitting to and/or sensing from the target region.
5.20200359936BREATHING GAS MEASURING DEVICE
US 19.11.2020
Int.Class A61B 5/097
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
097Devices for facilitating collection of breath or for directing breath into or through measuring devices
Appl.No 16987293 Applicant VYAIRE MEDICAL GMBH Inventor Hermann Eschenbacher

A respiratory air measuring device is provided through which a measuring air stream flows for measuring at least one component of the respiratory air of a patient. The respiratory air measuring device includes a sensor device and a flow generator disposed downstream for generating a measuring air stream. A flow nozzle is disposed in a channel portion to affect flow, wherein a generator air stream coming from the flow nozzle creates the measuring air stream. The respiratory air measuring device may be partially disassembled for effective cleaning.

6.20200359966COLLATERAL VENTILATION ASSESSMENT SYSTEM
US 19.11.2020
Int.Class A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
Appl.No 16874491 Applicant Gyrus ACMI, Inc. Inventor Paul W. Taylor

Disclosed embodiments include apparatuses, systems, and methods for assessing collateral ventilation. An illustrative embodiment includes an occlusion device insertable into a bronchial passageway to selectively seal the bronchial passageway to occlude a lobe of a lung. A flow lumen sealably extends through the occlusion device to a distal end and has a proximal end receptive of a positive pressure flow. A check valve is coupleable with the flow lumen to permit the positive pressure flow to pass to the distal end of the flow lumen and prevent a backflow of pressure from the flow lumen. A flow meter is couplable with the flow lumen to measure the positive pressure flow through the flow lumen. The occlusion device is insertable into the passageway to the isolated lobe. Measurements of the flow meter of the positive pressure flow into the occluded lobe are monitorable to assess collateral ventilation from the occluded lobe.

7.20200365276METHOD DEVICE AND SYSTEM FOR MONITORING SUB-CLINICAL PROGRESSION AND REGRESSION OF HEART FAILURE
US 19.11.2020
Int.Class G16H 50/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
30for calculating health indices; for individual health risk assessment
Appl.No 16933004 Applicant TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. Inventor Amir Landesberg

A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.

8.20200359935Oxygen Consumption and Energy Expenditure Monitoring
US 19.11.2020
Int.Class A61B 5/083
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
083Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
Appl.No 16762456 Applicant Children's Medical Center Corporation Inventor Peter Clemensen

A patient ventilation system and a computing device-implemented method determine oxygen consumption in a mechanically ventilated subject includes receiving a signal representing a total flow at an inspiratory outlet of a ventilator, calculating a transport delay time between inspiratory and expiratory gas sample points in a patient ventilation circuitry, transmitting a signal to an inlet selector valve to selectively open a fluid path between the inspiratory gas sample point and an oxygen sensor or between the expiratory gas sample point and the oxygen sensor, receiving data representing oxygen content and carbon dioxide content over a period of time, calculating oxygen consumption data over the period of time from the data representing the total flow, oxygen content and carbon dioxide content and from the transport delay time, and displaying the oxygen consumption data over the period of time.

9.20200359934BODY-WORN MONITOR FOR MEASURING RESPIRATION RATE
US 19.11.2020
Int.Class A61B 5/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
Appl.No 16827162 Applicant SOTERA WIRELESS, INC. Inventor Matthew BANET

The invention provides a multi-sensor system that uses an algorithm based on adaptive filtering to monitor a patient's respiratory rate. The system features a first sensor selected from the following group: i) an impedance pneumography sensor featuring at least two electrodes and a processing circuit configured to measure an impedance pneumography signal; ii) an ECG sensor featuring at least two electrodes and an ECG processing circuit configured to measure an ECG signal; and iii) a PPG sensor featuring a light source, photodetector, and PPG processing circuit configured to measure a PPG signal. Each of these sensors measures a time-dependent signal which is sensitive to respiratory rate and, during operation, is processed to determine an initial respiratory rate value. An adaptive digital filter is determined from the initial respiratory rate. The system features a second sensor (e.g. a digital 3-axis accelerometer) that attaches to the patient's torso and measures an ACC signal indicating movement of the chest or abdomen that is also sensitive to respiratory rate. This second signal is processed with the adaptive filter to determine a final value for respiratory rate.

10.WO/2020/231904REGIONAL PULMONARY V/Q VIA IMAGE REGISTRATION AND MULTI-ENERGY CT
WO 19.11.2020
Int.Class A61B 5/091
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
091Measuring volume of inspired or expired gases, e.g. to determine lung capacity
Appl.No PCT/US2020/032311 Applicant UNIVERSITY OF IOWA RESEARCH FOUNDATION Inventor HOFFMAN, Eric Alfred
A method for imaging a lung of a patient is provided. The method includes acquiring a full inspiration computed tomography (CT) scan of the lung to provide a total lung capacity (TLC) image and acquiring a functional residual capacity contrast enhanced multi-energy CT scan of the lung. The method further includes processing the functional residual capacity contrast enhanced multi-energy CT scan of the lung to generate a perfused blood volume (PBV) image and a virtual non-contrast (VNC) image. The method further includes registering the TLC image to at least one of the PBV and VNC images so as to provide a map of regional ventilation and to co-register local ventilation with blood perfusion, generating a lung performance metric using the co-registered images, and outputting the lung performance metric at a user interface of a computing device.