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1. WO2021067800 - ANTI-KIR3DL3 ANTIBODIES AND USES THEREOF

Publication Number WO/2021/067800
Publication Date 08.04.2021
International Application No. PCT/US2020/054063
International Filing Date 02.10.2020
IPC
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61K 35/17 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
Inventors
  • FREEMAN, Gordon, J.
  • ARULANANDAM, Antonio, R.
Agents
  • SMITH, DeAnn, F.
  • CAI, Mi
  • CHATTERLEY, Alexander, J.
  • AKHIEZER, Alexander
  • ABELLEIRA, Susan, M.
Priority Data
62/910,59404.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-KIR3DL3 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-KIR3DL3 ET LEURS UTILISATIONS
Abstract
(EN)
The present disclosure is based, in part, on the discovery of monoclonal antibodies, and antigen-binding fragments thereof, that specifically bind to KIR3DL3; bispecific antibodies and antigen-binding fragments thereof, that bind to KIR3DL3 and PD-1; as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for prognostic, immunomodulatory, and therapeutic purposes.
(FR)
La présente invention est basée, en partie, sur la découverte d'anticorps monoclonaux, et de leurs fragments de liaison à l'antigène, qui se lient spécifiquement à KIR3DL3 ; des anticorps bispécifiques et leurs fragments de liaison à l'antigène, qui se lient à KIR3DL3 et PD-1 ; ainsi que des immunoglobulines, des polypeptides, leurs acides nucléiques et des méthodes d'utilisation de tels anticorps à des fins thérapeutiques, immunomodulatrices et de pronostic.
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