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1. WO2021067761 - COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2 ANTIBODIES

Publication Number WO/2021/067761
Publication Date 08.04.2021
International Application No. PCT/US2020/054017
International Filing Date 02.10.2020
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • ATYR PHARMA, INC. [US]/[US]
Inventors
  • BURMAN, Luke
  • CHONG, Yeeting
  • GREENE, Leslie Ann
  • KING, David
  • XU, Zhiwen
  • ADAMS, Ryan Andrew
Agents
  • CHRISTIANSEN, William T.
  • ROGEL, Mark E.
Priority Data
62/910,04203.10.2019US
63/024,96014.05.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2 ANTIBODIES
(FR) COMPOSITIONS ET MÉTHODES COMPRENANT DES ANTICORPS ANTI-NRP2
Abstract
(EN)
Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
(FR)
L'invention concerne des anticorps humanisés et à maturation d'affinité et leurs fragments de liaison à l'antigène qui se lient spécifiquement à des polypeptides de neuropiline-2 (NRP2) humaine, y compris ceux qui modulent des interactions de liaison entre la NRP2 humaine et au moins un ligand de NRP2 et qui modulent ainsi des événements de signalisation en aval médiés par la NRP2 suivants, notamment des compositions thérapeutiques associées et des méthodes de modulation de l'activité de la NRP2 et de traitement de maladies telles que des maladies associées à la NRP2.
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