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1. WO2021067696 - ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Publication Number WO/2021/067696
Publication Date 08.04.2021
International Application No. PCT/US2020/053942
International Filing Date 02.10.2020
IPC
A61K 31/403 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
A61K 31/5025 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • VANDERBILT UNIVERSITY [US]/[US]
Inventors
  • LINDSLEY, Craig, W.
  • CONN, P., Jeffrey
  • BENDER, Aaron, M.
  • SPOCK, Matthew
  • HAN, Changho
Agents
  • CARROLL, Wiiliam, A.
  • HARTWIG, Gregory, J.
Priority Data
62/910,86304.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
(FR) ANTAGONISTES DU RÉCEPTEUR M4 D'ACÉTYLCHOLINE MUSCARINIQUE
Abstract
(EN)
Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
(FR)
L'invention concerne des composés hexahydro-1H-cyclopenta[c]pyrrole substitués, qui peuvent être utiles en tant qu'antagonistes du récepteur muscarinique M1 de l'acétylcholine M4 (mAChR M4). L'invention concerne également des procédés de fabrication des composés, des compositions pharmaceutiques comprenant les composés, et des procédés de traitement de troubles à l'aide des composés et des compositions.
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