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1. WO2021030238 - METHOD OF SYNTHESIS OF COMPOUND FOR DUAL INHIBITION OF JAK2 AND BET

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Publication Number WO/2021/030238
Publication Date 18.02.2021
International Application No. PCT/US2020/045555
International Filing Date 09.08.2020
IPC
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 31/496 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • OHM ONCOLOGY [US]/[US]
Inventors
  • UPADHAYAYA, Ram Shankar
  • UKKALAM, Murali Krishna
  • SARMA, K. Narasimha
Agents
  • WEINSTEIN, Peter, D.
Priority Data
62/885,19009.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF SYNTHESIS OF COMPOUND FOR DUAL INHIBITION OF JAK2 AND BET
(FR) PROCÉDÉ DE SYNTHÈSE D'UN COMPOSÉ DESTINÉ À UNE DOUBLE INHIBITION DE JAK2 ET BET
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Abstract
(EN)
Embodiments of the invention include quinoline compounds and methods of synthesis. Ohm-581 has demonstrated dual inhibition of JAK2 and BET and acts as a therapeutic agent for micosis fungoides (MF) and other hematologic malignancies. Embodiments also include an efficient process for the preparation of Ohm-581 and pharmaceutically acceptable salts. The process is suited for large-scale production of quinoline compounds including Ohm-581.
(FR)
Des modes de réalisation de l'invention concernent des composés de quinoléine et des procédés de synthèse. Ohm-581 a démontré une double Inhibition de JAK2 et BET et agit en tant qu'agent thérapeutique contre les mycoses fongoïdes (MF) et autres malignités hématologiques. Des modes de réalisation comprennent également un procédé efficace de préparation d'Ohm-581 et de sels pharmaceutiquement acceptables. Le procédé est adapté à une production à grande échelle de composés de quinoléine comprenant Ohm-581.
Latest bibliographic data on file with the International Bureau
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