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1. WO2021003462 - CATIONIC LIPIDS AND USES THEREOF

Publication Number WO/2021/003462
Publication Date 07.01.2021
International Application No. PCT/US2020/040813
International Filing Date 03.07.2020
IPC
C07C 215/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being saturated
06and acyclic
18with hydroxy groups and at least two amino groups bound to the carbon skeleton
C12N 15/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using liposome vesicle
C07C 213/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
08by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/44 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42107; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Applicants
  • FACTOR BIOSCIENCE INC. [US]/[US]
Inventors
  • ANGEL, Matthew
  • KOSTAS, Franklin
  • ROHDE, Christopher
Agents
  • ALTIERI, Stephen, L.
  • FRANK, Steven, J.
  • LIN, Yi-chia
  • CURRIE, Matthew, T.
  • HAYMAN, Mark, L.
Priority Data
62/870,24503.07.2019US
62/880,43530.07.2019US
63/023,65412.05.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CATIONIC LIPIDS AND USES THEREOF
(FR) LIPIDES CATIONIQUES ET LEURS UTILISATIONS
Abstract
(EN)
The present invention relates to novel cationic lipids of formula I, and more specifically formula IV. These are used, for example, in liposomes for the delivery of nucleic acids to cells.
(FR)
La présente invention concerne de nouveaux lipides cationiques de formule I, et plus particulièrement de formule IV. Les nouveaux lipides cationiques sont utilisés, par exemple, dans des liposomes pour l'administration d'acides nucléiques à des cellules.
Latest bibliographic data on file with the International Bureau