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1. WO2020234498 - GENE THERAPY WITH THE GENES HOKD AND LDRB FOR CANCER TREATMENTS

Publication Number WO/2020/234498
Publication Date 26.11.2020
International Application No. PCT/ES2020/070315
International Filing Date 15.05.2020
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C12N 15/63 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
C07K 14/245 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
24from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245Escherichia (G)
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants
  • UNIVERSIDAD DE GRANADA [ES]/[ES]
  • SERVICIO ANDALUZ DE SALUD [ES]/[ES]
Inventors
  • BOULAIZ TASSI, Houria
  • MARCHAL CORRALES, Juan Antonio
  • GRIÑÁN LISÓN, Carmen
  • JIMÉNEZ GONZÁLEZ, Gema
  • JIMÉNEZ MARTÍNEZ, Yaiza
Priority Data
P20193042715.05.2019ES
P20193042815.05.2019ES
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) GENE THERAPY WITH THE GENES HOKD AND LDRB FOR CANCER TREATMENTS
(ES) TERAPIA GÉNICA CON LOS GENES HOKD Y LDRB PARA EL TRATAMIENTO DEL CÁNCER
(FR) THÉRAPIE GÉNIQUE UTILISANT LES GÈNES HOKD ET LDRB POUR LE TRAITEMENT DU CANCER
Abstract
(EN)
The invention relates to the isolated RNA or DNA polynucleotides hokD and ldrB for use in medicine, particularly in gene therapy for cancer treatment. Also described are compositions comprising such polynucleotides or related genetic structures, and a method for treating proliferative disorders, preferably cancer.
(ES)
La invención descrita está relacionada con los polinucleótido de ARN o ADN aislados hokD y ldrB para uso en medicina, particularmente en terapia génica para el tratamiento del cáncer. También describe composiciones que comprenden tales polinucleótidos o construcciones genéticas relacionadas y un método de tratamiento de trastornos proliferativos, preferiblemente cáncer.
(FR)
L'invention concerne les polynucléotides d'ARN ou d'ADN isolés hokdD et IdrB destinés à être utilisés en médecine, en particulier en thérapie génique pour le traitement du cancer. L'invention concerne également des compositions comprenant de tels polynucléotides et un procédé de traitement de troubles prolifératifs, de préférence le cancer.
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