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Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2020/064132 C10625WO/DB
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
20 May 2020 20 May 2019
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61K 38/17 (2006.01)i; A61K 38/20 (2006.01)i; A61K 39/395 (2006.01)i; A61P 31/00 (2006.01)i; A61P 35/00 (2006.01)i; C07K 14/54 (2006.01)i; C07K 14/715 (2006.01)i; C07K 16/28 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     C07K; A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2018134784 A1 (NOVARTIS AG [CH]) 26 July 2018 (2018-07-26)
claims 1-16; examples 3,4
page 43, last paragraph - page 48, paragraph 3
US 2016175459 A1 (GEY ALAIN [FR] ET AL) 23 June 2016 (2016-06-23)
cited in the application
claims 1-20; sequence 19
paragraphs [0218], [0219], [0221], [0224], [0227], [0233], [0236], [0239]; example 1
US 2015359853 A1 (FELBER BARBARA K [US] ET AL) 17 December 2015 (2015-12-17)
paragraphs [0233] - [0276]; claims 1-13; examples 2,3
US 2016184399 A1 (BECHARD DAVID [FR] ET AL) 30 June 2016 (2016-06-30)
paragraphs [0124], [0125], [0130], [0134] - [0138]
claims 1-11; sequence 16
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2018134784 A1
26 July 2018
EP 3570870 A1
US 2020237874 A1
WO 2018134784 A1
27 November 2019
30 July 2020
26 July 2018
US 2016175459 A1
23 June 2016
AU 2014304931 A1
BR 112016002614 A2
CA 2919725 A1
CN 105612175 A
DK 3030575 T3
EA 201690333 A1
EP 3030575 A1
EP 3444271 A1
ES 2690046 T3
HR P20181472 T1
JP 6649254 B2
JP 2016532693 A
JP 2020072726 A
KR 20160042922 A
PL 3030575 T3
PT 3030575 T
SI 3030575 T1
US 2016175459 A1
WO 2015018528 A1
25 February 2016
12 September 2017
12 February 2015
25 May 2016
22 October 2018
30 June 2016
15 June 2016
20 February 2019
19 November 2018
02 November 2018
19 February 2020
20 October 2016
14 May 2020
20 April 2016
31 December 2018
31 October 2018
30 November 2018
23 June 2016
12 February 2015
US 2015359853 A1
17 December 2015
AU 2013334610 A1
CA 2888896 A1
EP 2911684 A2
ES 2747997 T3
HK 1211467 A1
IL 238476 A
JP 6359019 B2
JP 2015536935 A
MX 365527 B
NZ 630790 A
US 2015359853 A1
US 2019209653 A1
WO 2014066527 A2
14 May 2015
01 May 2014
02 September 2015
12 March 2020
27 May 2016
29 August 2019
18 July 2018
24 December 2015
06 June 2019
25 November 2016
17 December 2015
11 July 2019
01 May 2014
US 2016184399 A1
30 June 2016
CA 2920539 A1
CN 105579062 A
DK 3030262 T3
EP 3030262 A1
EP 3659622 A1
ES 2760249 T3
HR P20192174 T1
HU E046964 T2
JP 2016527286 A
JP 2019189638 A
KR 20160040632 A
LT 3030262 T
PL 3030262 T3
PT 3030262 T
SI 3030262 T1
US 2016184399 A1
WO 2015018529 A1
12 February 2015
11 May 2016
02 December 2019
15 June 2016
03 June 2020
13 May 2020
06 March 2020
28 April 2020
08 September 2016
31 October 2019
14 April 2016
10 March 2020
27 July 2020
11 December 2019
31 March 2020
30 June 2016
12 February 2015
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
07 August 2020
Date of mailing of the international search report:
24 August 2020
Authorized officer:
Böhmerova, Eva
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