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1. WO2020234270 - A PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND INTERMEDIATE THEREOF

Publication Number WO/2020/234270
Publication Date 26.11.2020
International Application No. PCT/EP2020/063908
International Filing Date 19.05.2020
IPC
C07H 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
C07H 15/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
CPC
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
C07H 15/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
C07H 15/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
26Acyclic or carbocyclic radicals, substituted by hetero rings
Applicants
  • H. LUNDBECK A/S [DK]/[DK]
Inventors
  • JUHL, Martin
  • JACOBSEN, Mikkel, Fog
  • KVÆRNØ, Lisbet
Priority Data
PA20190059820.05.2019DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND INTERMEDIATE THEREOF
(FR) PROCÉDÉ DE FABRICATION DE (2S,3S,4S,5R,6S) -3,4,5-TRIHYDROXY-6-(((4AR,10AR)-HYDROXY-1-PROPYL-1,2,3,4,4 A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TÉTRAHYDRO-2H-PYRAN-2-CARBOXYLIQUE ET UN INTERMÉDIAIRE DE CELUI-CI
Abstract
(EN)
The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5- trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a- octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and pharmaceutically acceptable salts thereof. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to a new intermediate of said process.
(FR)
La présente invention concerne un procédé de fabrication de (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4 a,5,10,10a-octahydrobenzo[g]quinolin-6-yl) oxy)tétrahydro-2H-pyran-2-carboxylique de formule (Id) ci-dessous et des sels pharmaceutiquement acceptables de celui-ci. Le composé de formule (Id) est un promédicament d'une catécholamine destiné à être utilisé dans le traitement de maladies et de troubles neurodégénératifs tels que la maladie de Parkinson. L'invention concerne également un nouvel intermédiaire dudit procédé.
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