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1. WO2020210429 - METHODS FOR ENRICHING POPULATIONS OF CELLS

Publication Number WO/2020/210429
Publication Date 15.10.2020
International Application No. PCT/US2020/027375
International Filing Date 09.04.2020
IPC
A61K 35/28 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 35/51 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
51Umbilical cord; Umbilical cord blood; Umbilical stem cells
A61K 35/50 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
Applicants
  • RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US]/[US]
  • DEZAWA, Mari [JP]/[JP]
Inventors
  • DEZAWA, Mari
  • YOUNG, Wise
  • SUN, Dongming
  • TADMORI, Iman
  • LENG, Zikuan
Agents
  • BUTCH, Peter J.
  • CHEN, Joe
  • BARRISON, Flynn
Priority Data
62/831,49109.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR ENRICHING POPULATIONS OF CELLS
(FR) PROCÉDÉS POUR ENRICHIR DES POPULATIONS DE CELLULES
Abstract
(EN)
This disclosure describes efficient methods for separating desired populations of cells, including Multilineage-Differentiating Stress-Enduring (MUSE) cells. Also described are the methods for isolating and enriching MUSE cells through a sorting, expanding, and re-sorting procedure. The enriched cells or cell populations can be used for treating cancer, repairing various tissues, and treating various degenerative or inherited diseases.
(FR)
La présente invention concerne des procédés efficaces pour séparer des populations souhaitées de cellules, y compris des cellules résistantes au stress à différenciation par multilignage (MUSE). L'invention concerne également les procédés d'isolement et d'enrichissement de cellules MUSE par le biais d'une procédure de tri, d'expansion et de retri. Les cellules ou les populations cellulaires enrichies peuvent être utilisées pour traiter le cancer, réparer divers tissus et traiter diverses maladies dégénératives ou héréditaires.
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