Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020208065 - PROTEIN NANO- OR MICROPARTICLES AS ARTIFICIAL INCLUSION BODIES

Publication Number WO/2020/208065
Publication Date 15.10.2020
International Application No. PCT/EP2020/059994
International Filing Date 08.04.2020
IPC
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
B82Y 5/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C07K 14/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
001by chemical synthesis
Applicants
  • UNIVERSITAT AUTONOMA DE BARCELONA [ES]/[ES]
  • INSTITUT RECERCA HOSPITAL DE LA SANTA CREU I SANT PAU [ES]/[ES]
  • CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P. (CIBER) [ES]/[ES]
Inventors
  • VILLAVERDE CORRALES, Antonio
  • VÁZQUEZ GÓMEZ, Esther
  • LÓPEZ LAGUNA, Héctor
  • SÁNCHEZ, Julieta María
  • MANGUES BAFALLUY, Ramón
  • ALAMO, Patricia
Priority Data
19382271.511.04.2019EP
19382909.017.10.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROTEIN NANO- OR MICROPARTICLES AS ARTIFICIAL INCLUSION BODIES
(FR) NANO OU MICROPARTICULES PROTÉIQUES UTILISÉES EN TANT QUE CORPS D'INCLUSION ARTIFICIELS
Abstract
(EN)
The invention relates to protein particles comprising a cluster of one or more types of assembled self-contained protein, wherein the particle has a size from 50 nm to 50 micrometers; is in form of a pellet in aqueous media; is mechanically stable; and it release a particular percentage by weight of the self-contained protein within a predetermined period of time, and any other compound contained in the particle. Particular methods for obtaining the particles are also disclosed, said methods comprising the addition of salts to allow precipitation of proteins. Particular protein particles comprising lipids associated with the assembly of self-contained proteins are also disclosed. The invention also relates to several uses of the particle, in particular medical uses and to pharmaceutical and cosmetic compositions comprising the particles.
(FR)
L'invention concerne des particules protéiques comprenant un agrégat d'un ou plusieurs types de protéines indépendantes assemblées. La particule a une taille de 50 nm à 50 micromètres ; se présente sous la forme d'une pastille dans un milieu aqueux ; est mécaniquement stable ; et libère un pourcentage en poids particulier de la protéine indépendante dans une période de temps prédéfinie, et de tout autre composé contenu dans la particule. L'invention concerne également des procédés particuliers permettant d'obtenir les particules, lesdits procédés comprenant l'ajout de sels pour permettre la précipitation de protéines. L'invention concerne également des particules protéiques particulières comprenant des lipides associés à l'assemblage de protéines indépendantes. L'invention concerne également plusieurs utilisations de la particule, en particulier des utilisations médicales et des compositions pharmaceutiques et cosmétiques comprenant les particules.
Latest bibliographic data on file with the International Bureau