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1. WO2020186027 - INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS

Publication Number WO/2020/186027
Publication Date 17.09.2020
International Application No. PCT/US2020/022334
International Filing Date 12.03.2020
IPC
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • TOMITA, Daisuke [US]/[US]
  • LAMA, Lodoe [US]/[US]
  • TUSCHL, Thomas [US]/[US]
  • PATEL, Dinshaw [US]/[US]
  • GLICKMAN, J. Fraser [US]/[US]
  • KAMEI, Taku [US]/[US]
  • MILLER, Michael [US]/[US]
  • ASANO, Yasutomi [JP]/[JP]
  • OKAMOTO, Rei [JP]/[JP]
  • HASHIZUME, Shogo [JP]/[JP]
  • AIDA, Jumpei [JP]/[JP]
  • IMAEDA, Toshihiro [JP]/[JP]
  • MICHINO, Mayako [US]/[US]
  • KUROITA, Takanobu [JP]/[JP]
Inventors
  • TOMITA, Daisuke
  • LAMA, Lodoe
  • TUSCHL, Thomas
  • PATEL, Dinshaw
  • GLICKMAN, J. Fraser
  • KAMEI, Taku
  • MILLER, Michael
  • ASANO, Yasutomi
  • OKAMOTO, Rei
  • HASHIZUME, Shogo
  • AIDA, Jumpei
  • IMAEDA, Toshihiro
  • MICHINO, Mayako
  • KUROITA, Takanobu
Agents
  • BOHNSTEDT, Adolph
Priority Data
62/817,75913.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS
(FR) INHIBITEURS DE CGAZ POUR LE TRAITEMENT DE MALADIES AUTO-INFLAMMATOIRES ET DE MÉTASTASES CANCÉREUSES
Abstract
(EN)
Tri-cyclyl nitrogen-containing heterocyclic compounds are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
(FR)
L'invention concerne des composés hétérocycliques contenant de l'azote tri-cyclyle. Les composés sont des inhibiteurs de cGAS humain dans des types de cellules productrices d'interférons. Ils sont ainsi utiles en tant qu'agents thérapeutiques pour le traitement de maladies auto-immunes associées au cGAS chez l'homme.
Latest bibliographic data on file with the International Bureau