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1. WO2020184677 - ANTI-HEPATITIS B VIRUS AGENT

Publication Number WO/2020/184677
Publication Date 17.09.2020
International Application No. PCT/JP2020/010910
International Filing Date 12.03.2020
IPC
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07H 19/19 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
19with arabinosyl as the saccharide radical
A61K 31/7076 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
Applicants
  • ダイキン工業株式会社 DAIKIN INDUSTRIES, LTD. [JP]/[JP]
  • 国立大学法人 鹿児島大学 KAGOSHIMA UNIVERSITY [JP]/[JP]
Inventors
  • 濱田 智仁 HAMADA, Tomohito
  • 池内 秀幸 IKEUCHI, Hideyuki
  • 稲生 佳菜子 INOO, Kanako
  • 岸川 洋介 KISHIKAWA, Yosuke
  • 池田 正徳 IKEDA, Masanori
  • 武田 緑 TAKEDA, Midori
Agents
  • 特許業務法人三枝国際特許事務所 SAEGUSA & PARTNERS
Priority Data
2019-04695414.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTI-HEPATITIS B VIRUS AGENT
(FR) AGENT CONTRE LE VIRUS DE L’HÉPATITE B
(JA) 抗B型肝炎ウイルス剤
Abstract
(EN)
The present invention addresses the problem of providing an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-associated diseases, containing a nucleic acid analog as an active ingredient. The problem can be solved by an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-associated diseases, containing, as an active ingredient, a compound represented by formula (1) (in the formula, R represents a halogen atom, an amino group, a methoxy group, or a cyano group) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
(FR)
Le problème à résoudre par la présente invention est de fournir un agent qui agit contre le virus de l'hépatite B et un agent prophylactique ou thérapeutique qui agit contre des maladies associées au virus de l'hépatite B, chaque agent comprenant un analogue d'acide nucléique en tant que principe actif. La solution de l'invention porte sur un agent qui agit contre le virus de l'hépatite B et un agent prophylactique ou thérapeutique qui agit contre des maladies associées au virus de l'hépatite B, contenant, en tant que principe actif, un composé représenté par la formule (1) (dans la formule, R représente un atome d'halogène, un groupe amino, un groupe méthoxy, ou un groupe cyano) ou un promédicament de celui-ci, ou un sel pharmaceutiquement acceptable de celui-ci, ou un solvate de celui-ci.
(JA)
核酸アナログを有効成分として含有する、抗B型肝炎ウイルス剤及びB型肝炎ウイルス関連疾患の予防又は治療剤の提供を課題とする。 前記課題は、次式(1): (式中、Rは、ハロゲン原子、アミノ基、メトキシ基、又はシアノ基である。) で表される化合物若しくはそのプロドラッグ、又はそれらの薬学的に許容される塩、或いはそれらの溶媒和物を有効成分として含有する抗B型肝炎ウイルス剤及びB型肝炎ウイルス関連疾患の予防又は治療剤により解決することができる。
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