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1. WO2020183227 - TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A COMPLICATION RISK FACTOR

Publication Number WO/2020/183227
Publication Date 17.09.2020
International Application No. PCT/IB2019/052012
International Filing Date 12.03.2019
IPC
A61K 31/5383 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
A61P 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
CPC
A61K 31/5383
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
Applicants
  • SHIONOGI & CO., LTD. [JP]/[JP]
Inventors
  • UEHARA, Takeki
  • KAWAGUCHI, Keiko
  • HOWELL, Ann
  • PORTSMOUTH, Simon
Agents
  • SUGITA, Ken-ichi
  • WATANABE, HIdeaki
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A COMPLICATION RISK FACTOR
(FR) TRAITEMENT DE LA GRIPPE À L'AIDE DE DÉRIVÉS POLYCYCLIQUES SUBSTITUÉS DE PYRIDONE ET DE PROMÉDICAMENTS CORRESPONDANTS CHEZ UN SUJET ATTEINT DE GRIPPE ET PRÉSENTANT UN FACTEUR DE RISQUE DE COMPLICATION
Abstract
(EN)
A method for treating an influenza virus infection is described. The disclosed method generally involves administering an effective amount of a compound, for example baloxavir marboxil, to a subject having an influenza virus infection and at least one complication risk factor. Generally, the amount is effective such that a reduction in a time to improvement of at least one symptom of an influenza virus infection is statistically significant as compared to that of a non-treated subject.
(FR)
L'invention concerne un procédé de traitement d'une infection par un virus de la grippe. Le procédé selon l'invention implique, d'une manière générale, l'administration d'une quantité efficace d'un composé, par exemple le baloxavir marboxil, à un sujet atteint d'une infection par un virus de la grippe et présentant au moins un facteur de risque de complication. Généralement, la quantité est efficace de telle sorte qu'une réduction dans le temps pour améliorer au moins un symptôme d'une infection par un virus de la grippe est statistiquement significative par rapport à celle d'un sujet non traité.
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