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1. WO2020182077 - USE OF GLI2 INHIBITOR AND METHOD FOR SCREENING COMPOUND INHIBITING GLI2

Publication Number WO/2020/182077
Publication Date 17.09.2020
International Application No. PCT/CN2020/078224
International Filing Date 06.03.2020
IPC
C07C 405/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
405Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
A61K 31/5575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
557Eicosanoids, e.g. leukotrienes
5575having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C40B 30/04 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
04by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
Applicants
  • 中国科学院动物研究所 INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES [CN]/[CN]
Inventors
  • 王宇 WANG, Yu
  • 吴付佳 WU, Fujia
Agents
  • 北京市中咨律师事务所 ZHONGZI LAW OFFICE
Priority Data
201910174832.808.03.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) USE OF GLI2 INHIBITOR AND METHOD FOR SCREENING COMPOUND INHIBITING GLI2
(FR) UTILISATION D'UN INHIBITEUR DE GLI2 ET PROCÉDÉ DE CRIBLAGE D'UN COMPOSÉ INHIBANT GLI2
(ZH) GLI2抑制剂的用途以及抑制GLI2的化合物的筛选方法
Abstract
(EN)
A prostaglandin as represented by formula I and an analog thereof used as medicines, and a pharmaceutical composition containing the compounds, particularly used as an inhibitor of zinc finger domain-containing protein GLI2 (i.e., glioma-associated oncogene-2), and used for treatment, prevention, or alleviation of tumors (particularly tumor resistance) in subjects, or neurodegenerative diseases or developmental syndromes and malformations caused by dysregulation of signaling pathways involving GLI2. Also provided is a method for screening a compound inhibiting GLI2.
(FR)
L'invention concerne une prostaglandine représentée par la formule I et un analogue de celle-ci utilisé comme médicament, et une composition pharmaceutique contenant les composés, en particulier utilisée en tant qu'inhibiteur de la protéine GLI2 contenant un domaine à doigts de zinc (c'est-à-dire, l'oncogène associé au gliome-2), et utilisée pour le traitement, la prévention ou le soulagement de tumeurs (en particulier la résistance tumorale) chez des sujets, ou des maladies neurodégénératives ou des syndromes de développement et des malformations provoquées par une dysrégulation de voies de signalisation impliquant GLI2. L'invention concerne également un procédé de criblage d'un composé inhibant GLI2.
(ZH)
用作药物的式I的前列腺素和其类似物以及包含这些化合物的药物组合物,特别是用作含锌指结构域的蛋白GLI2(即神经胶质瘤相关的癌基因-2)的抑制剂,以及用于治疗、预防或减轻受试者中的肿瘤(尤其是肿瘤抗性)或GLI2参与的信号传导通路失调导致的神经变性疾病或发育综合征和畸形。还提供了抑制GLI2的化合物的筛选方法。
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