Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020154705 - HIGH-DENSITY LIPOPROTEIN MIMETIC NANOPARTICLES USING LIPID CONJUGATED CORE SCAFFOLDS

Publication Number WO/2020/154705
Publication Date 30.07.2020
International Application No. PCT/US2020/015109
International Filing Date 24.01.2020
IPC
A61K 9/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 47/69 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C07K 14/775 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
775Apolipopeptides
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Applicants
  • NORTHWESTERN UNIVERSITY [US]/[US]
Inventors
  • HENRICH, Stephen E.
  • THAXTON, C. Shad
  • NGUYEN, Sonbinh T.
  • HONG, Bong Jin
Agents
  • LOCKHART, Helen C.
  • DAM, Kevin, T.
  • ATTISHA, Michael, J.
  • AMUNDSEN, Eric, L.
  • ALAM, Saad
Priority Data
62/796,53424.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HIGH-DENSITY LIPOPROTEIN MIMETIC NANOPARTICLES USING LIPID CONJUGATED CORE SCAFFOLDS
(FR) NANOPARTICULES MIMÉTIQUES DE LIPOPROTÉINES À HAUTE DENSITÉ UTILISANT DES ÉCHAFAUDAGES DE CŒURS CONJUGUÉS À DES LIPIDES
Abstract
(EN)
Disclosed herein are spherical high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core). Also disclosed herein are methods for synthesizing the spherical HDL-NPs. Also disclosed herein are methods for treating disorders such as cardiovascular disease, cancer, inflammatory disorders or reducing NF-kB activity with the spherical HDL-NPs.
(FR)
L'invention concerne des nanoparticules sphériques de type lipoprotéines à haute densité (HDL-NP) ayant un cœur de matériau souple (par exemple, un cœur inorganique conjugué à des lipides). L'invention concerne également des procédés de synthèse des HDL-NP sphériques. L'invention concerne également des méthodes de traitement de troubles tels qu'une maladie cardiovasculaire, le cancer, des troubles inflammatoires ou de réduction de l'activité de NF-kB à l'aide des HDL-NP sphériques.
Latest bibliographic data on file with the International Bureau