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1. WO2020154686 - NR2E3 EXPRESSION REDUCING OLIGONUCLEOTIDES, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF THEIR USE

Publication Number WO/2020/154686
Publication Date 30.07.2020
International Application No. PCT/US2020/015087
International Filing Date 24.01.2020
IPC
C12N 15/113 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12Q 1/6809 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6809Methods for determination or identification of nucleic acids involving differential detection
C12N 15/111
Applicants
  • NAYAN THERAPEUTICS, INC. [US]/[US]
Inventors
  • SEWACK, Gerald
  • JANICOT, Michel
Agents
  • MICHAUD, Susan, M.
Priority Data
62/796,91125.01.2019US
62/796,92025.01.2019US
62/797,00625.01.2019US
62/869,81902.07.2019US
62/869,86902.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NR2E3 EXPRESSION REDUCING OLIGONUCLEOTIDES, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF THEIR USE
(FR) OLIGONUCLÉOTIDES RÉDUCTEURS D'EXPRESSION DE NR2E3, COMPOSITIONS LES CONTENANT, ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
Disclosed are oligonucleotides having a nucleobase sequence with at least 6 contiguous nucleobases complementary to an equal-length portion within a NR2E3 target nucleic acid. Also disclosed are pharmaceutical compositions containing the oligonucleotides and methods of their use.
(FR)
L'invention concerne des oligonucléotides ayant une séquence de nucléobases avec au moins 6 nucléobases contiguës complémentaires à une partie de longueur égale dans un acide nucléique cible de NR2E3. L'invention concerne également des compositions pharmaceutiques contenant les oligonucléotides et des procédés d'utilisation de celles-ci.
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