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1. WO2020102746 - PROTEIN AND PEPTIDE DELIVERY SYSTEMS AND METHODS FOR MAKING AND USING THEM

Publication Number WO/2020/102746
Publication Date 22.05.2020
International Application No. PCT/US2019/061839
International Filing Date 15.11.2019
IPC
C07K 14/21 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
21from Pseudomonadaceae (F)
C07K 14/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
28from Vibrionaceae (F)
C12N 15/74 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
C12N 15/78 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
78for Pseudomonas
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, DBA SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION [US]/[US]
  • J. CRAIG VENTER INSTITUTE [US]/[US]
  • ETH ZURICH [CH]/[CH]
Inventors
  • SHIKUMA, Nicholas J.
  • BEYHAN, Sinem
  • PILHOFER, Martin
  • ERICSON, Charles
Agents
  • EINHORN, Gregory P.
Priority Data
62/768,24016.11.2018US
62/844,98808.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROTEIN AND PEPTIDE DELIVERY SYSTEMS AND METHODS FOR MAKING AND USING THEM
(FR) SYSTÈMES D'ADMINISTRATION DE PROTÉINE ET DE PEPTIDE, PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
Abstract
(EN)
Provided are compositions, kits, and methods for delivering a proteinaceous cargo, or a protein or a peptide, or a drug or a marker, to or into a cell or to an individual in need thereof. Methods comprise use of: a substantially purified or isolated bacterial Contractile Injection Systems (CIS) or Metamorphosis Associated Contractile structure; a recombinant bacterial Contractile Injection Systems (CIS) or Metamorphosis Associated Contractile structure (MACs); a liposome or lipid-comprising nanoparticle incorporating or expressing on its outer surface the substantially purified or isolated bacterial CIS or MACs, or the recombinant bacterial CIS or MACs; a protoplast or a spheroplast incorporating or expressing on its outer surface the substantially purified or isolated bacterial CIS or MACs, or the recombinant bacterial CIS or MACs; a cell expressing on its extracellular surface the substantially purified or isolated bacterial CIS or MACs, or the recombinant bacterial CIS or MACs.
(FR)
L'invention concerne des compositions, des kits et des procédés d'administration de cargo protéinique, ou d'une protéine ou d'un peptide, ou d'un médicament ou d'un marqueur, à une cellule ou à un individu en ayant besoin. Les procédés comprennent l'utilisation : de systèmes d'injection contractiles (CIS) bactériens sensiblement purifiés ou isolés ou une structure contractile associée à une métamorphose ; de systèmes d'injection contractiles (CIS) bactériens recombinés ou une structure contractile associée à une métamorphose (MAC) ; un liposome ou une nanoparticule comprenant des lipides incorporant ou exprimant sur sa surface externe les CIS ou MAC bactériens sensiblement purifiés ou isolés, ou les CIS ou MAC bactériens recombinés ; un protoplaste ou un sphéroplaste incorporant ou exprimant sur sa surface externe les CIS ou MAC bactériens sensiblement purifiés ou isolés, ou les CIS ou MAC bactériens recombinés ; une cellule exprimant sur sa surface extracellulaire les CIS ou MAC bactériens sensiblement purifiés ou isolés, ou les CIS ou MAC bactériens recombinés.
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