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1. WO2020102698 - MILLING WITH ULTRAVIOLET EXCITATION

Publication Number WO/2020/102698
Publication Date 22.05.2020
International Application No. PCT/US2019/061765
International Filing Date 15.11.2019
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 21/17 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
Applicants
  • UNIVERSITY OF HOUSTON SYSTEM [US]/[US]
Inventors
  • MAYERICH, David
  • ERIKSEN, Jason
Agents
  • CHIEU, Polin
Priority Data
62/767,62015.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MILLING WITH ULTRAVIOLET EXCITATION
(FR) FRAISAGE AVEC EXCITATION PAR RAYONNEMENT ULTRAVIOLET
Abstract
(EN)
Milling with ultraviolet excitation (MUVE) realizes high-throughput multiplex imaging of large three-dimensional samples. The instrumentation may comprise a UV- source attachment, precision stage attachment, and/or a blade assembly, and the instrumentation may overcome several constraints inherent to current state-of-the-art three-dimensional microscopy. MUVE offers throughput that is orders of magnitude faster than other technology by collecting a two-dimensional array of pixels simultaneously. The proposed instrumentation also utilizes serial ablation and provides the opportunity for true whole-organ imaging at microscopic resolution.
(FR)
L'invention concerne le fraisage avec excitation par rayonnement ultraviolet (MUVE) réalisant une imagerie multiplexe à haut rendement de grands échantillons tridimensionnels. L'instrumentation peut comprendre un élément de fixation de source UV, un élément de fixation d'étage de précision et/ou un ensemble lame, et l'instrumentation peut surmonter plusieurs contraintes inhérentes à la microscopie tridimensionnelle de l'état de la technique. Le fraisage MUVE offre un débit qui présente des ordres de grandeur plus rapides que d'autres technologies par la collecte simultanée d'un réseau bidimensionnel de pixels. L'instrumentation selon la présente invention utilise également une ablation en série et fournit l'opportunité pour une imagerie d'organe entier réel à une résolution microscopique.
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