Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020102668 - RNA INTERFERENCE DELIVERY FORMULATION AND METHODS FOR MALIGNANT TUMORS

Publication Number WO/2020/102668
Publication Date 22.05.2020
International Application No. PCT/US2019/061702
International Filing Date 15.11.2019
IPC
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 47/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Applicants
  • NITTO DENKO CORPORATION [JP]/[JP]
Inventors
  • MAJETI, Bharat
  • CLAMME, Jean-Pierre
  • WANG, Li
  • ADAMI, Roger, C.
  • YING, Wenbin
Agents
  • MALLON, Joseph, J.
Priority Data
62/768,82616.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RNA INTERFERENCE DELIVERY FORMULATION AND METHODS FOR MALIGNANT TUMORS
(FR) FORMULATION D'ADMINISTRATION D'ARN INTERFÉRENTS ET MÉTHODES DE TRAITEMENT DE TUMEURS MALIGNES
Abstract
(EN)
This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.
(FR)
La présente invention concerne des formulations destinées à être utilisées pour distribuer des molécules d'ARNi ciblés sur une GST-π humaine en vue de traiter une tumeur maligne chez un sujet. La formulation peut comprendre des nanoparticules composées d'un lipide ionisable, d'un lipide DSPE et de lipides supplémentaires. Un produit médicamenteux peut être préparé par la lyophilisation de la formulation. L'invention concerne en outre des méthodes destinées à faire régresser ou à traiter une tumeur maligne par l'administration d'une quantité thérapeutiquement efficace d'une formulation contenant les agents d'ARNi.
Latest bibliographic data on file with the International Bureau