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1. WO2020101826 - METHOD OF PERSONALIZED TREATMENT FOR GLIOBLASTOMA AND OTHER RELATED DISEASES USING A NOVEL GLIOBLASTOMA PROGNOSTIC INDEX

Publication Number WO/2020/101826
Publication Date 22.05.2020
International Application No. PCT/US2019/055720
International Filing Date 10.10.2019
IPC
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C40B 30/06 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
06by measuring effects on living organisms, tissues or cells
Applicants
  • ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US]/[US]
Inventors
  • WETERINGS, Eric
  • STEA, Baldassarre D.
  • MAHADEVAN, Daruka
  • MORRISON, Christopher Michael
  • HAMMER, Michael F.
Agents
  • NGUYEN, Quan
Priority Data
62/767,91415.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PERSONALIZED TREATMENT FOR GLIOBLASTOMA AND OTHER RELATED DISEASES USING A NOVEL GLIOBLASTOMA PROGNOSTIC INDEX
(FR) PROCÉDÉ DE TRAITEMENT PERSONNALISÉ POUR LE GLIOBLASTOME ET D'AUTRES MALADIES ASSOCIÉES À L'AIDE D'UN NOUVEL INDICE PRONOSTIQUE POUR LE GLIOBLASTOME
Abstract
(EN)
The present invention relates to diagnostic assays useful in classification of patients for selection of cancer therapy, and relates to a method of using a select family member of the Wnt signaling pathway (WIF1), an important component of the insulin-like growth factor pathway (IGFBP3), and other signaling factors (e.g., NGFR, I BSP, and TP53) as prognostic markers and potential therapeutic targets for patients with Glioblastoma Multiforme (GBM). In particular, the present invention is a novel GBM Prognostic Index (GPI) that predicts overall survival (OS) in GBM patients treated with the current standard of care.
(FR)
La présente invention concerne des dosages diagnostiques utiles dans la classification de patients pour la sélection d'une thérapie anticancéreuse, et concerne un procédé d'utilisation d'un membre de la famille sélectionné de la voie de signalisation Wnt (WIF1), un composant important de la voie du facteur de croissance de type insuline (IGFBP3), et d'autres Facteurs de signalisation (par exemple NGFR, I BSP, et TP53) en tant que marqueurs pronostiques et cibles thérapeutiques potentielles pour des patients atteints de glioblastome multiforme (GBM). En particulier, la présente invention est un nouvel indice pronostique pour GBM (GPI) prédisant la survie globale (OS) chez des patients atteints de GBM traités avec les standards de soins actuels.
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