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1. WO2020101460 - CARRIER FOR CELL CULTURE COMPRISING MICROCAPSULES CONTAINING NATURAL OIL

Publication Number WO/2020/101460
Publication Date 22.05.2020
International Application No. PCT/KR2019/095041
International Filing Date 12.11.2019
IPC
C12N 5/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
Applicants
  • 한국화학연구원 KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY [KR]/[KR]
Inventors
  • 강선웅 KANG, Sun Woong
  • 심혜은 SHIM, Hye Eun
Agents
  • 김순웅 KIM, Soon Woong
Priority Data
10-2018-013921013.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) CARRIER FOR CELL CULTURE COMPRISING MICROCAPSULES CONTAINING NATURAL OIL
(FR) PORTEUR POUR CULTURE CELLULAIRE COMPRENANT DES MICROCAPSULES CONTENANT DE L'HUILE NATURELLE
(KO) 천연 오일을 함유하는 미세캡슐을 포함하는 세포 배양용 캐리어
Abstract
(EN)
The present invention relates to a carrier for cell culture and, more specifically, to a carrier for cell culture and a cell culture medium composition comprising same, the carrier for cell culture comprising microcapsules which contain gelatin, a natural polymer, an oil, and an oil thickener and have improved mechanical properties. The microcapsules containing a natural oil, according to the present invention, have significantly improved mechanical properties and retention. When used as a carrier for cell culture in culturing cells, the microcapsules have the effects of improving adhesion and survival of the cells and inducing maturation of the cultured cells, and thus can be variously employed in cell culture using a carrier, co-culture systems, and the field of artificial cell structure production.
(FR)
La présente invention porte sur un porteur pour culture cellulaire et, plus particulièrement, sur un porteur pour culture cellulaire et une composition de milieu de culture cellulaire le comprenant, le porteur pour culture cellulaire comprenant des microcapsules contenant de la gélatine, un polymère naturel, une huile et un épaississant d'huile, et ayant des propriétés mécaniques améliorées. Les microcapsules contenant une huile naturelle, selon la présente invention, ont des propriétés mécaniques et une rétention significativement améliorées. Lorsqu'il est utilisé en tant que porteur pour la culture cellulaire dans des cellules de culture, les microcapsules ont pour effet d'améliorer l'adhésion et la survie des cellules et d'induire la maturation des cellules cultivées, et peuvent ainsi être utilisées de diverses manières dans une culture cellulaire à l'aide d'un porteur, dans des systèmes de co-culture et dans le domaine de la production de structure cellulaire artificielle.
(KO)
본 발명은 세포 배양용 캐리어에 관한 것으로서, 더욱 상세하게는 젤라틴, 천연 고분자, 오일 및 오일 점증제를 함유하며, 기계적 물성이 향상된 미세캡슐을 포함하는 세포 배양용 캐리어 및 이를 포함하는 세포 배양 배지 조성물에 관한 것이다. 본 발명에 따른 천연 오일을 함유하는 미세캡슐은 기계적 물성 및 유지도가 현저히 증가된 것이다. 상기 미세캡슐을 세포 배양용 캐리어로 사용하여 세포를 배양하는 경우 세포의 부착 및 생존을 향상시키며, 배양된 세포의 성숙화를 유도하는 효과를 가지고 있는바, 캐리어를 이용한 세포 배양, 공배양 시스템 및 인공 세포 구조체 제작 분야에서 다양하게 활용할 수 있다.
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