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1. WO2020030532 - SIMPLIFIED REGENERATION OF APHERESIS COLUMNS

Publication Number WO/2020/030532
Publication Date 13.02.2020
International Application No. PCT/EP2019/070840
International Filing Date 01.08.2019
IPC
A61M 1/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 1/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
CPC
A61M 1/3486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3472with treatment of the filtrate
3486Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
A61M 1/3496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3496Plasmapheresis; Leucopheresis; Lymphopheresis
A61M 1/3679
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; ; Extra-corporeal blood circuits
3679by absorption
A61M 1/3696
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; ; Extra-corporeal blood circuits
3693using separation based on different densities of components, e.g. centrifuging
3696with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
A61M 2202/0445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2202Special media to be introduced, removed or treated
04Liquids
0413Blood
0445Proteins
A61M 2205/7554
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2205General characteristics of the apparatus
75with filters
7554with means for unclogging or regenerating filters
Applicants
  • PENTRACOR GMBH [DE]/[DE]
Inventors
  • SHERIFF, Ahmed
  • VOGT, Birgit
  • BOCK, Christopher
Agents
  • ARTH, Hans-Lothar
Priority Data
18187611.106.08.2018EP
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VEREINFACHTE REGENERATION VON APHERESESÄULEN
(EN) SIMPLIFIED REGENERATION OF APHERESIS COLUMNS
(FR) RÉGÉNÉRATION SIMPLIFIÉE DE COLONNES D'APHÉRÈSE
Abstract
(DE)
Die vorliegende Erfindung betrifft eine Apheresevorrichtung(1)zur extrakorporalen Entfernung von CRP aus Blut eines Patienten, wobei die Apheresevorrichtung an den Blutkreislauf des Patienten anschließbar ist. Das Blut wird über einen Teil des extrakorporalen Zirkulationssystems(2)der erfindungsgemäßen Apheresevorrichtung (1) zu einem Zellseparator(7) zur Auftrennung des Bluts in Blutplasma und zelluläre Bestandteile gepumpt. Über einen ersten Ausgang des Zellseparators (7) wird das abgetrennte Blutplasma über eine Plasmaleitung (8A) zu einer Apheresesäule (4) zur affinitätschromatographischen Entfernung von CRP aus dem Blutplasma geleitet. Nach der Entfernung des CRPs aus dem Blutplasma des Patienten wird dieses nun behandelte Blutplasma über eine Plasmaleitung (8B) mit den zellulären Bestandteilen des Bluts zusammengeführt. Des Weiteren umfasst die erfindungsgemäße Apheresevorrichtung (1) eine Bypass-Leitung (12), die von der Plasmaleitung (8A) in die Plasmaleitung (8B) führt unter Umgehung der Apheresesäule (4). Ferner umfasst die erfindungsgemäße Apheresevorrichtung (1) eine Regenerationsleitung (14), die in die Plasmaleitung (8A) oder direkt in die Apheresesäule (4) mündet.
(EN)
The invention relates to an apheresis device (1) for the extracorporeal removal of C-reactive protein from blood of a patient. The apheresis device can be connected to the blood circulation of the patient. The blood is pumped via a part of the extracorporeal circulation system (2) of the apheresis device (1) according to the invention to a cell separator (7) for separating the blood into blood plasma and cellular constituents. Via a first outlet of the cell separator (7), the separated blood plasma is conducted by means of a plasma line (8A) to an apheresis column (4) for removing C-reactive protein from the blood plasma by affinity chromatography. After the C-reactive protein has been removed from the blood plasma of the patient, said blood plasma which has now been treated is combined with the cellular constituents of the blood via a plasma line (8B). Furthermore, the apheresis device (1) according to the invention comprises a bypass line (12), which leads from the plasma line (8A) into the plasma line (8B) while bypassing the apheresis column (4). The apheresis device (1) according to the invention also comprises a regeneration line (14), which leads into the plasma line (8A) or directly into the apheresis column (4).
(FR)
La présente invention concerne un dispositif d'aphérèse (1) destiné à l'élimination extra-corporelle de la CRP hors du sang d'un patient, le dispositif d'aphérèse pouvant être relié au circuit sanguin du patient. Selon l'invention, le sang est pompé, par l'intermédiaire d'une partie du système de circulation extra-corporel (2) du dispositif d'aphérèse (1), vers un séparateur de cellules (7) destiné à séparer le sang en plasma sanguin et en composants cellulaires. Le plasma sanguin séparé est conduit, par l'intermédiaire d'une première sortie du séparateur de cellules (7), par l'intermédiaire d'une conduite à plasma (8A), vers une colonne d'aphérèse (4) destinée à l'élimination par chromatographie par affinité de la CRP hors du plasma sanguin. Après l'élimination de la CRP hors du plasma sanguin du patient, ledit plasma sanguin à présent traité est remélangé avec les composants cellulaires du sang par l'intermédiaire d'une conduite à plasma (8B). En outre, selon la présente invention, le dispositif d'aphérèse (1) comprend une conduite de dérivation (12) qui mène de la conduite à plasma (8A) à la conduite à plasma (8B) en contournant la colonne d'aphérèse (4). Selon la présente invention, le dispositif d'aphérèse (1) comprend également une conduite de régénération (14) qui débouche dans la conduite à plasma (8A) ou directement dans la colonne d'aphérèse (4).
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Latest bibliographic data on file with the International Bureau