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1. WO2014045254 - HUMAN BETACORONAVIRUS LINEAGE C AND IDENTIFICATION OF N-TERMINAL DIPEPTIDYL PEPTIDASE AS ITS VIRUS RECEPTOR

Publication Number WO/2014/045254
Publication Date 27.03.2014
International Application No. PCT/IB2013/058772
International Filing Date 23.09.2013
IPC
C12N 7/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
C07K 14/005 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
A61K 39/215 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
CPC
A61K 35/76
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 14/70596
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 2319/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
C12N 2770/20021
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
20011Coronaviridae
20021Viruses as such, e.g. new isolates, mutants or their genomic sequences
Applicants
  • ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM [NL]/[NL]
Inventors
  • HAAGMANS, Bartholomeus, Leonardus
  • BESTEBROER, Theodorus, Marinus
  • VAN BOHEEMEN, Sander
  • FOUCHIER, Ronaldus, Adrianus, Maria
  • OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus
  • ZAKI, Ali, Moh
  • RAJ, Victor, Stalin
  • BOSCH, Berend, Jan
Agents
  • JANSEN, C., M.
Priority Data
61/704,53123.09.2012US
61/730,02726.11.2012US
61/831,07004.06.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN BETACORONAVIRUS LINEAGE C AND IDENTIFICATION OF N-TERMINAL DIPEPTIDYL PEPTIDASE AS ITS VIRUS RECEPTOR
(FR) LIGNÉE C DE CORONAVIRUS BÊTA HUMAINS ET IDENTIFICATION DE LA PEPTIDASE DIPEPTIDYLIQUE N-TERMINALE EN TANT QUE RÉCEPTEUR VIRAL
Abstract
(EN)
The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.
(FR)
L'invention concerne un virus à ARN à simple brin à polarité positive essentiellement mammalien isolé pouvant être classifié comme appartenant à l'ordre : Nidovirales; famille : Coronaviridae; sous-famille : Coronavirinae; genre : coronavirus bêta; et coronavirus bêta humain n'appartenant pas à la lignée A, à la lignée B ou à la lignée D. L'invention concerne également un virus humain comprenant un domaine de liaison au récepteur (RBD) capable de se lier à une peptidase dipeptidylique 4. L'invention concerne également des moyens et des procédés de diagnostic, des moyens et des procédés prophylactiques et des moyens et des procédés thérapeutiques à employer pour le diagnostic, la prévention et/ou le traitement d'une maladie, notamment d'une maladie respiratoire, en particulier de mammifères, plus particulièrement d'êtres humains.
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