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1. CN111560354 - 重组新型冠状病毒及其制备方法和应用

Office China
Application Number 202010439738.3
Application Date 22.05.2020
Publication Number 111560354
Publication Date 21.08.2020
Publication Kind A
IPC
C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/295
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
295Polyvalent viral antigens; Mixtures of viral and bacterial antigens
A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
Applicants 中国人民解放军总医院第五医学中心
北京麦迪理邦生物科技有限公司
Inventors 杨鹏辉
王希良
程晋霞
王欢
孙芳
Agents 北京纪凯知识产权代理有限公司 11245
Title
(ZH) 重组新型冠状病毒及其制备方法和应用
Abstract
(ZH)
本发明公开了重组新型冠状病毒及其制备方法和应用。本发明首先公开了重组病毒,该重组病毒的流感病毒的NS基因、流感病毒的HA基因和流感病毒的NA基因中任一种基因被替换。本发明进一步公开了上述重组病毒在制备预防和/或治疗流感病毒和/或SARS‑CoV‑2引起的疾病的产品中的应用。本发明从基因水平对SARS‑CoV‑2抗原表位和流感病毒基因组进行操作,基于RG技术制备流感病毒为载体的重组SARS‑CoV‑2疫苗株,解决了SARS‑CoV‑2疫苗短缺难题,将是冠状病毒疫苗领域的新里程碑,且SARS‑CoV‑2嵌合疫苗可以保护更多人群免受流感病毒和SARS‑CoV‑2之害。