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1. CN111548396 - 一种新型冠状病毒T细胞抗原表位肽、pMHC及其制备和应用

Office China
Application Number 202010306192.4
Application Date 17.04.2020
Publication Number 111548396
Publication Date 18.08.2020
Publication Kind A
IPC
C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C07K 14/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
74Major histocompatibility complex (MHC)
G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Applicants 暨南大学
Inventors 陈国兵
邱聪龄
王鹏程
罗钧洪
高利娟
Agents 广州粤高专利商标代理有限公司 44102
Title
(ZH) 一种新型冠状病毒T细胞抗原表位肽、pMHC及其制备和应用
Abstract
(ZH)
本发明公开了一种新型冠状病毒T细胞抗原表位肽、pMHC及其制备和应用。所述新型冠状病毒T细胞抗原表位肽,其氨基酸序列如SEQ IDNO:1~9任一所示。本发明发现了9种新型冠状病毒T细胞抗原表位肽,并利用其制备得到了pMHC复合物单聚体,进一步制备得到pMHC复合物多聚体,其可以用于新型冠状病毒感染康复者外周血内抗原特异性T细胞的检测,并用于体外的T细胞活化实验,这些新型冠状病毒T细胞抗原表位肽可以应用到新型冠状病毒相关的免疫检测中。