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1. CN111518175 - SARS-COV-2抗原多肽及其重组腺相关病毒和在制备疫苗中的应用

Office China
Application Number 202010392553.1
Application Date 11.05.2020
Publication Number 111518175
Publication Date 11.08.2020
Publication Kind A
IPC
C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
C12N 15/864
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
864Parvoviral vectors
A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants 广州派真生物技术有限公司
广州中医药大学(广州中医药研究院)
Inventors 周泽鑫
刘中秋
廖国超
李华鹏
张超
戚笑笑
陈君霖
杨德盈
Agents 广州市华学知识产权代理有限公司 44245
Title
(ZH) SARS-COV-2抗原多肽及其重组腺相关病毒和在制备疫苗中的应用
Abstract
(ZH)
本发明公开了SARS‑COV‑2抗原多肽及其重组腺相关病毒和在制备疫苗中的应用,所述的抗原多肽序列如SEQ.ID.NO.1和SEQ.ID.NO.2所示。所述的重组腺相关病毒是将将pHelper、pRep2Cap5和抗原多肽的表达载体共孵育,在转染试剂聚乙烯亚胺存在的条件下转染细胞,培育细胞后,经过裂解和纯化,得到含有重组腺相关病毒的纯化液。本发明的重组腺相关病毒在体内递送表达产生融合抗原多肽,诱导产生血清中和抗体,对SARS‑COV‑2新冠病毒具有中和效价,并持续表达,可用于对人进行针对COVID‑19新冠肺炎的免疫接种。