SEQUENCE LISTING <110> University Health Network Brokx, Richard Mason, Jacqueline M. Bray, Mark R. <120> TSG-6 ANTIBODIES AND USES THEREFOR <130> 08945437WO <150> US 62/817,152 <151> 2019-03-12 <160> 104 <170> PatentIn version 3.5 <210> 1 <211> 262 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 1 Met Glu Arg His Trp Ile Phe Leu Ser Leu Leu Ser Val Ile Ala Gly 1 5 10 15 Val His Ser Gln Val Arg Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Tyr Ile Ile Pro Ser Ser Gly Tyr Thr Lys Asn Lys 65 70 75 80 Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Gln Leu Ser Asn Leu Thr Tyr Glu Asp Ser Ala Val 100 105 110 Tyr Ser Cys Ala Arg Ser Asp Gly Ser Tyr Pro Tyr Tyr Phe Asp Tyr 115 120 125 Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 145 150 155 160 Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 165 170 175 Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 180 185 190 Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 195 200 205 Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala 210 215 220 His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 225 230 235 240 Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 245 250 255 Phe Ile Phe Pro Pro Lys 260 <210> 2 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 2 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Glu Asn Val Leu Thr Gln Ser Pro Ala Ile 20 25 30 Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser 50 55 60 Pro Lys Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 65 70 75 80 Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser Gly Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 115 120 125 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 130 135 140 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 145 150 155 160 Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 165 170 175 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 180 185 190 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 195 200 205 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 210 215 220 Pro 225 <210> 3 <211> 287 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 3 Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn 65 70 75 80 Glu Lys Phe Lys Asp Lys Ala Thr Trp Thr Ile Asp Thr Ser Ser Asn 85 90 95 Arg Ala Tyr Met Glu Ile His Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Phe Cys Ala Arg Gly Leu Trp Tyr Tyr Val Ser Gly Met Asp Tyr 115 120 125 Trp Gly Pro Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 145 150 155 160 Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 165 170 175 Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 180 185 190 Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 195 200 205 Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala 210 215 220 His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 225 230 235 240 Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 245 250 255 Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 260 265 270 Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 4 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 4 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5 10 15 Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 20 25 30 Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Arg Gly Ser Gly Ile Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 100 105 110 Ser Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro 225 <210> 5 <211> 287 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 5 Met Glu Arg His Trp Ile Phe Leu Ser Leu Leu Ser Val Ile Ala Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 20 25 30 Pro Gly Ala Ser Val Arg Leu Ser Cys Gln Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Arg Gln Gly Leu 50 55 60 Glu Trp Ile Gly Tyr Ile Ile Pro Ser Ser Gly Tyr Thr Lys Cys His 65 70 75 80 Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Ser Thr Ser Gly Tyr Pro Tyr Tyr Phe Asp Ser 115 120 125 Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 145 150 155 160 Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 165 170 175 Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 180 185 190 Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 195 200 205 Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala 210 215 220 His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 225 230 235 240 Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 245 250 255 Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 260 265 270 Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 6 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 6 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Glu Asn Val Leu Thr Gln Ser Pro Ala Ile 20 25 30 Met Ser Ala Ser Pro Gly Glu Arg Val Thr Met Thr Cys Ser Ala Thr 35 40 45 Ser Ser Val Ser Phe Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser 50 55 60 Pro Lys Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 65 70 75 80 Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser Trp Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 115 120 125 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 130 135 140 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 145 150 155 160 Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 165 170 175 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 180 185 190 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 195 200 205 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 210 215 220 Pro 225 <210> 7 <211> 287 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 7 Met Glu Arg His Trp Ile Phe Leu Ser Leu Leu Ser Val Ile Ala Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 20 25 30 Pro Gly Ala Ser Val Arg Leu Ser Cys Gln Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Thr Tyr Trp Met His Trp Val Lys Gln Arg Pro Arg Gln Gly Leu 50 55 60 Glu Trp Ile Gly Tyr Ile Ile Pro Ser Ser Gly Tyr Ser Lys Cys His 65 70 75 80 Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn 85 90 95 Thr Ala Ser Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Ser Thr Ser Gly Tyr Pro Tyr Tyr Phe Asp Tyr 115 120 125 Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 145 150 155 160 Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 165 170 175 Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 180 185 190 Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 195 200 205 Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala 210 215 220 His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 225 230 235 240 Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 245 250 255 Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 260 265 270 Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 8 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 8 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Glu Asn Val Leu Thr Gln Ser Pro Ala Ile 20 25 30 Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Thr 35 40 45 Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser 50 55 60 Pro Lys Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 65 70 75 80 Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser Trp Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 115 120 125 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 130 135 140 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 145 150 155 160 Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 165 170 175 Gln Asp Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 180 185 190 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 195 200 205 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 210 215 220 Pro 225 <210> 9 <211> 285 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 9 Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Met Ile His Pro Asn Ser Gly Ser Thr Asn Tyr Asn 65 70 75 80 Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Ala Pro Arg Met Phe Asp Asp Tyr Asp Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 145 150 155 160 Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 165 170 175 Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 180 185 190 Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 195 200 205 Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 210 215 220 Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 225 230 235 240 Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 245 250 255 Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 260 265 270 Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 10 <211> 226 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 10 Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val 1 5 10 15 Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 20 25 30 Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser 35 40 45 Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser 50 55 60 Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val 65 70 75 80 Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 85 90 95 Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His His 100 105 110 Tyr His Arg Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 115 120 125 Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 130 135 140 Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 145 150 155 160 Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 165 170 175 Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 180 185 190 Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 195 200 205 Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 210 215 220 Ser Pro 225 <210> 11 <211> 286 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 11 Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Glu Lys Ser Leu 50 55 60 Glu Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn 65 70 75 80 Gln Lys Phe Met Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg 85 90 95 Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Thr Val 100 105 110 Tyr Tyr Cys Ala Arg Trp Gly Ile Tyr Asp Arg Phe Thr Tyr Trp Gly 115 120 125 Gln Gly Thr Leu Val Ser Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 145 150 155 160 Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 165 170 175 Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 180 185 190 Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 195 200 205 Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 210 215 220 Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 225 230 235 240 Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 245 250 255 Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 260 265 270 Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln Gly 275 280 285 <210> 12 <211> 226 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 12 Met Asp Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp 1 5 10 15 Phe Pro Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser 20 25 30 Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Ala Cys Lys Ala Ser 35 40 45 Gln Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys 50 55 60 Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val 65 70 75 80 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr 85 90 95 Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln 100 105 110 Tyr Asp Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 115 120 125 Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 130 135 140 Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 145 150 155 160 Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 165 170 175 Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 180 185 190 Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 195 200 205 Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 210 215 220 Ser Pro 225 <210> 13 <211> 287 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 13 Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe 35 40 45 Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Trp Ile Tyr Pro Ser Asp Gly Ser Thr Lys Phe Asn 65 70 75 80 Glu Lys Phe Lys Gly Met Ala Thr Leu Thr Val Asp Thr Ser Ser Ser 85 90 95 Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Thr Val 100 105 110 Tyr Phe Cys Ala Arg Gly Leu Trp Tyr Tyr Gly Gly Gly Val Asp Tyr 115 120 125 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 145 150 155 160 Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 165 170 175 Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 180 185 190 Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 195 200 205 Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala 210 215 220 His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 225 230 235 240 Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 245 250 255 Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 260 265 270 Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 14 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 14 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5 10 15 Ser Ser Ser Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 20 25 30 Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu 35 40 45 Glu Asp Ser Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Leu Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 100 105 110 Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro 225 <210> 15 <211> 285 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 15 Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 50 55 60 Glu Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 65 70 75 80 Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Trp Gly Ile Phe Asp Arg Phe Thr Tyr Trp Gly 115 120 125 Gln Gly Thr Val Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 145 150 155 160 Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 165 170 175 Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 180 185 190 Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 195 200 205 Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 210 215 220 Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 225 230 235 240 Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 245 250 255 Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 260 265 270 Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 16 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 16 Met Asp Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp 1 5 10 15 Phe Pro Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser 20 25 30 Met Tyr Ala Ser Arg Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser 35 40 45 Gln Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys 50 55 60 Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val 65 70 75 80 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr 85 90 95 Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln 100 105 110 Tyr Asp Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 115 120 125 Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 130 135 140 Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 145 150 155 160 Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 165 170 175 Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 180 185 190 Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 195 200 205 Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 210 215 220 Lys 225 <210> 17 <211> 259 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 17 Met Gly Trp Ser Trp Ile Phe Leu Leu Ser Leu Pro Gly Thr Ala Gly 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Asp Tyr Asn Met Asp Trp Val Lys Gln Ser His Gly Glu Ser Leu 50 55 60 Glu Trp Ile Gly Asp Ile Tyr Pro Asn Asn Gly Gly Thr Ile Tyr Asn 65 70 75 80 Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Asn Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Lys Thr Gly Thr Gly Phe Asp Tyr Trp Gly Gln 115 120 125 Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 130 135 140 Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 145 150 155 160 Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 165 170 175 Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 180 185 190 Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 195 200 205 Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala 210 215 220 Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 225 230 235 240 Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 245 250 255 Pro Pro Lys <210> 18 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 18 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Arg 35 40 45 Ser Ser Val Ile Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile Tyr Ala Thr Phe Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105 110 Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 115 120 125 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 130 135 140 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 145 150 155 160 Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 165 170 175 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 180 185 190 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 195 200 205 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 210 215 220 Pro 225 <210> 19 <211> 256 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 19 Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Ser Gln Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Met Ile His Pro Asn Ser Gly Ser Thr Asn Asn Asn 65 70 75 80 Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Thr Arg Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 115 120 125 Val Thr Ala Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 130 135 140 Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 145 150 155 160 Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 165 170 175 Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 180 185 190 Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 195 200 205 Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 210 215 220 Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 225 230 235 240 Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 245 250 255 <210> 20 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 20 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5 10 15 Ser Ser Thr Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 20 25 30 Ser Leu Gly Asp Leu Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 100 105 110 Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro 225 <210> 21 <211> 291 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 21 Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 1 5 10 15 Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 20 25 30 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 50 55 60 Glu Trp Leu Gly Phe Ile Arg His Lys Ala Lys Gly Tyr Thr Ala Glu 65 70 75 80 Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 85 90 95 Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser 100 105 110 Ala Thr Tyr Tyr Cys Ala Arg Leu Tyr Tyr Tyr Gly Ser Pro His Trp 115 120 125 Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala 130 135 140 Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 145 150 155 160 Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 165 170 175 Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 180 185 190 Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 195 200 205 Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr 210 215 220 Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 225 230 235 240 Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 245 250 255 Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 260 265 270 Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 275 280 285 Asp Asp Gln 290 <210> 22 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 22 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Ile Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 20 25 30 Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 50 55 60 Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105 110 Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile Lys 115 120 125 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 130 135 140 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 145 150 155 160 Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 165 170 175 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 180 185 190 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 195 200 205 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 210 215 220 Pro 225 <210> 23 <211> 299 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 23 Met Gly Trp Ser Cys Ile Met Leu Phe Leu Ala Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Tyr Thr Phe 35 40 45 Thr Asn Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu 50 55 60 Glu Trp Ile Gly Arg Ile Asp Pro Ser Ser Gly Gly Ala Lys Tyr Asn 65 70 75 80 Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser 85 90 95 Thr Ala Tyr Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Val Arg Ser Arg Tyr Asp Tyr Asp Gly Trp Phe Ala Tyr 115 120 125 Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser 145 150 155 160 Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val 165 170 175 Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe 180 185 190 Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr 195 200 205 Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala 210 215 220 His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly 225 230 235 240 Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys 245 250 255 Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro 260 265 270 Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr 275 280 285 Cys Val Val Val Asp Val Ser Glu Asp Asp Gln 290 295 <210> 24 <211> 229 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 24 Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 1 5 10 15 Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro 20 25 30 Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 35 40 45 Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 50 55 60 Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 65 70 75 80 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 85 90 95 Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 100 105 110 Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys 115 120 125 Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 130 135 140 Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 145 150 155 160 Leu Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp 165 170 175 Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 180 185 190 Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 195 200 205 Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 210 215 220 Thr Ser Thr Ser Pro 225 <210> 25 <211> 285 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 25 Met Glu Trp Ile Trp Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly 1 5 10 15 Val Gln Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Asp Thr Phe 35 40 45 Ile Asn Tyr Gly Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Glu Thr Phe Pro Ser Asn Gly Asn Thr Phe Tyr Asn 65 70 75 80 Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser 85 90 95 Thr Thr Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ala Ala Val 100 105 110 Tyr Phe Cys Ala Arg His Ser Asn Leu Pro Tyr Phe Asp His Trp Gly 115 120 125 Gln Gly Ser Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 145 150 155 160 Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 165 170 175 Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 180 185 190 Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 195 200 205 Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 210 215 220 Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 225 230 235 240 Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 245 250 255 Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 260 265 270 Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Gln 275 280 285 <210> 26 <211> 230 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 26 Met Glu Ser Gln Thr Gln Val Leu Ile Ser Leu Leu Phe Trp Val Ser 1 5 10 15 Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 20 25 30 Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 35 40 45 Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 50 55 60 Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg 65 70 75 80 Glu Ser Gly Val Pro Glu Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 85 90 95 Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 100 105 110 Tyr Cys Gln Asn Asp His Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr 115 120 125 Asn Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 130 135 140 Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 145 150 155 160 Phe Leu Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile 165 170 175 Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 180 185 190 Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 195 200 205 Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 210 215 220 Lys Thr Ser Thr Ser Pro 225 230 <210> 27 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 27 Gly Tyr Thr Phe Thr Ser Tyr Trp 1 5 <210> 28 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 28 Ile Ile Pro Ser Ser Gly Tyr Thr 1 5 <210> 29 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 29 Ala Arg Ser Asp Gly Ser Tyr Pro Tyr Tyr Phe Asp Tyr 1 5 10 <210> 30 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 30 Ser Ser Val Ser Tyr 1 5 <210> 31 <400> 31 000 <210> 32 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 32 Phe Gln Gly Ser Gly Tyr Pro Leu Thr 1 5 <210> 33 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 33 Gly Tyr Thr Phe Thr Ser Tyr Asp 1 5 <210> 34 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 34 Ile Tyr Pro Arg Asp Gly Ser Thr 1 5 <210> 35 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 35 Ala Arg Gly Leu Trp Tyr Tyr Val Ser Gly Met Asp Tyr 1 5 10 <210> 36 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 36 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 1 5 10 <210> 37 <400> 37 000 <210> 38 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 38 Gln Ser Thr His Val Pro Pro Thr 1 5 <210> 39 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 39 Gly Tyr Thr Phe Thr Ser Tyr Trp 1 5 <210> 40 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 40 Ile Ile Pro Ser Ser Gly Tyr Thr 1 5 <210> 41 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 41 Ala Arg Ser Thr Ser Gly Tyr Pro Tyr Tyr Phe Asp Ser 1 5 10 <210> 42 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 42 Ser Ser Val Ser Phe 1 5 <210> 43 <400> 43 000 <210> 44 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 44 Phe Gln Gly Ser Trp Tyr Pro Leu Thr 1 5 <210> 45 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 45 Gly Tyr Thr Phe Thr Thr Tyr Trp 1 5 <210> 46 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 46 Ile Ile Pro Ser Ser Gly Tyr Ser 1 5 <210> 47 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 47 Ala Arg Ser Thr Ser Gly Tyr Pro Tyr Tyr Phe Asp 1 5 10 <210> 48 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 48 Ser Ser Val Ser Tyr 1 5 <210> 49 <400> 49 000 <210> 50 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 50 Phe Gln Gly Ser Trp Tyr Pro Leu Thr 1 5 <210> 51 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 51 Gly Tyr Thr Phe Thr Ser Tyr Trp 1 5 <210> 52 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 52 Ile His Pro Asn Ser Gly Ser Thr 1 5 <210> 53 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 53 Ala Pro Arg Met Phe Asp Asp Tyr Asp Asp Tyr 1 5 10 <210> 54 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 54 Ser Ser Val Ser Ser Ser Tyr 1 5 <210> 55 <400> 55 000 <210> 56 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 56 His His Tyr His Arg Ser Pro Tyr Thr 1 5 <210> 57 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 57 Gly Tyr Thr Phe Thr Asp Tyr Tyr 1 5 <210> 58 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 58 Ile Asn Pro Asn Asn Gly Gly Thr 1 5 <210> 59 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 59 Ala Arg Trp Gly Ile Tyr Asp Arg Phe Thr Tyr 1 5 10 <210> 60 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 60 Gln Asp Ile Asn Ser Phe 1 5 <210> 61 <400> 61 000 <210> 62 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 62 Leu Gln Tyr Asp Glu Phe Pro Leu Thr 1 5 <210> 63 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 63 Gly Tyr Thr Phe Thr Ser Tyr Asp 1 5 <210> 64 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 64 Ile Tyr Pro Ser Asp Gly Ser Thr 1 5 <210> 65 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 65 Ala Arg Gly Leu Trp Tyr Tyr Gly Gly Gly Val Asp Tyr 1 5 10 <210> 66 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 66 Gln Ser Leu Glu Asp Ser Asn Gly Asn Thr Tyr 1 5 10 <210> 67 <400> 67 000 <210> 68 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 68 Leu Gln Val Thr His Val Pro Tyr Thr 1 5 <210> 69 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 69 Gly Tyr Thr Phe Thr Asp Tyr Tyr 1 5 <210> 70 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 70 Ile Asn Pro Asn Asn Gly Gly Thr 1 5 <210> 71 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 71 Ala Arg Trp Gly Ile Phe Asp Arg Phe Thr Tyr 1 5 10 <210> 72 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 72 Gln Asp Ile Asn Ser Phe 1 5 <210> 73 <400> 73 000 <210> 74 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 74 Leu Gln Tyr Asp Glu Phe Pro Leu Thr 1 5 <210> 75 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 75 Gly Tyr Thr Phe Thr Asp Tyr Asn 1 5 <210> 76 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 76 Ile Tyr Pro Asn Asn Gly Gly Thr 1 5 <210> 77 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 77 Ala Arg Lys Thr Gly Thr Gly Phe Asp Tyr 1 5 10 <210> 78 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 78 Ser Val Ile Tyr 1 <210> 79 <400> 79 000 <210> 80 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 80 Gln Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 81 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 81 Gly Tyr Thr Phe Thr Ser Gln Trp 1 5 <210> 82 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 82 Ile His Pro Asn Ser Gly Ser Thr 1 5 <210> 83 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 83 Thr Arg Trp Ala Met Asp Tyr 1 5 <210> 84 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 84 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 1 5 10 <210> 85 <400> 85 000 <210> 86 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 86 Ser Gln Ser Thr His Val Pro Trp Thr 1 5 <210> 87 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 87 Gly Phe Thr Phe Thr Asp Tyr Tyr 1 5 <210> 88 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 88 Ile Arg His Lys Ala Lys Gly Tyr Thr Ala 1 5 10 <210> 89 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 89 Ala Arg Leu Tyr Tyr Tyr Gly Ser Pro His Trp Tyr Phe Asp Val 1 5 10 15 <210> 90 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 90 Ser Ser Val Ser Tyr 1 5 <210> 91 <400> 91 000 <210> 92 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 92 Gln Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 93 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 93 Asp Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 94 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 94 Ile Asp Pro Ser Ser Gly Gly Ala 1 5 <210> 95 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 95 Val Arg Ser Arg Tyr Asp Tyr Asp Gly Trp Phe Ala Tyr 1 5 10 <210> 96 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 96 Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 <210> 97 <400> 97 000 <210> 98 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 98 Met Gln His Leu Glu Tyr Pro Phe Thr 1 5 <210> 99 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 99 Asp Asp Thr Phe Ile Asn Tyr Gly 1 5 <210> 100 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 100 Thr Phe Pro Ser Asn Gly Asn Thr 1 5 <210> 101 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 101 Ala Arg His Ser Asn Leu Pro Tyr Phe Asp His 1 5 10 <210> 102 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 102 Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 1 5 10 <210> 103 <400> 103 000 <210> 104 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 104 Gln Asn Asp His Ser Tyr Pro Phe Thr 1 5